S29434
- CAS No.
- 874484-20-5
- Chemical Name:
- S29434
- Synonyms
- S29434;S29434, 10 mM in DMSO;N-(2-(2-Methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide;2-Furancarboxamide, N-[2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl]-;cell-permeable,inhibit,selective,S 29434,HepG2,mice,NMDPEF,S-29434,ROS,Autophagy,S29434,Inhibitor,memory;N-(2-{5-methoxy-1,6,11-triazatetracyclo[7.7.0.02,?.01?,1?]hexadeca-2(7),3,5,8,10(15),11,13-heptaen-8-yl}ethyl)furan-2-carboxamide
- CBNumber:
- CB45476532
- Molecular Formula:
- C21H18N4O3
- Molecular Weight:
- 374.39
- MDL Number:
- MOL File:
- 874484-20-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
S29434 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ZJB48420 | S29434 | 874484-20-5 | 25mg | $957 | 2026-06-05 | Buy |
| Biosynth | ZJB48420 | S29434 | 874484-20-5 | 50mg | $1331.5 | 2026-06-05 | Buy |
| Biosynth | ZJB48420 | S29434 | 874484-20-5 | 100mg | $2131 | 2026-06-05 | Buy |
| ChemScene | CS-0087517 | S29434 99.29% | 874484-20-5 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0087517 | S29434 99.29% | 874484-20-5 | 10mg | $271 | 2026-06-04 | Buy |
S29434 Chemical Properties,Uses,Production
Uses
S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1].
in vivo
S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1].
| Animal Model: | CH3 wild-type mice[1] |
| Dosage: | 1 and 15 mg/kg |
| Administration: | Intraperitoneal injection; 1 and 15 mg/kg once |
| Result: | Positively affected memory by inhibiting QR2. |
References
[1] Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285. DOI:10.1124/mol.118.114231
S29434 Preparation Products And Raw materials
Raw materials
Preparation Products
S29434 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 3905209149@qq.com | China | 9716 | 58 |
