4-Nitrophenylhydrazine hydrochloride
- CAS No.
- 636-99-7
- Chemical Name:
- 4-Nitrophenylhydrazine hydrochloride
- Synonyms
- P-NITROPHENYLHYDRAZINE HYDROCHLORIDE;4-Nitrophenylhydrazi;P-NITROPHENYLHYDRAZINE HCL;4-nitrophenyl hydrazine hcl;NITROPHENYLHYDRAZINE HYDROCHLORIDE;4-NITROPHENYHYDRAZINE HYDROCHLORIDE;(4-nitrophenyl)hydrazinhydrochlorid;4-NITROPHENYLHYDRAZINE HYDROCHLORIDE;Amino-(4-nitrophenyl)azanium chloride;4-Hydrazinonitrobenzene hydrochloride
- CBNumber:
- CB4683522
- Molecular Formula:
- C6H8ClN3O2
- Molecular Weight:
- 189.6
- MDL Number:
- MFCD00040592
- MOL File:
- 636-99-7.mol
- MSDS File:
- SDS
| Melting point | 205-207°C |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO, Methanol, Water |
| form | Solid |
| color | Brown to Reddish Brown |
| BRN | 3569014 |
| InChI | InChI=1S/C6H7N3O2.ClH/c7-8-5-1-3-6(4-2-5)9(10)11;/h1-4,8H,7H2;1H |
| InChIKey | ZWWXDCOPVYATOQ-UHFFFAOYSA-N |
| SMILES | N(C1=CC=C([N+]([O-])=O)C=C1)N.[H]Cl |
| CAS DataBase Reference | 636-99-7(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Nitrophenylhydrazine hydrochloride (636-99-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-24/25-22 | |||||||||
| RIDADR | 2811 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2928009090 | |||||||||
| NFPA 704 |
|
4-Nitrophenylhydrazine hydrochloride price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | N0233 | 4-Nitrophenylhydrazine Hydrochloride >98.0%(HPLC)(T) | 636-99-7 | 5g | $33 | 2026-04-30 | Buy |
| TCI Chemical | N0233 | 4-Nitrophenylhydrazine Hydrochloride >98.0%(HPLC)(T) | 636-99-7 | 25g | $158 | 2026-04-30 | Buy |
| TRC | TRC-N503770-25G | 4-Nitrophenylhydrazine Hydrochloride | 636-99-7 | 25g | $142 | 2026-06-03 | Buy |
| TRC | TRC-N503770-250G | 4-Nitrophenylhydrazine Hydrochloride | 636-99-7 | 250g | $1100 | 2026-06-03 | Buy |
| Biosynth | FN38735 | 4-Nitrophenylhydrazine hydrochloride | 636-99-7 | 0.25kg | $319 | 2026-06-04 | Buy |
4-Nitrophenylhydrazine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
PINK TO ORANGE CRYSTALLINE POWDER
Uses
4-Nitrophenylhydrazine is a nitro substituted aryl hydrazine with potential anticancer activity.
Synthesis
100-01-6
636-99-7
The general procedure for the synthesis of 4-nitrophenylhydrazine hydrochloride from 4-nitroaniline was as follows: 4-nitroaniline (1.47 g, 10.6 mmol) was dissolved in concentrated hydrochloric acid (2 mL) and the solution was cooled to 0°C. A solution of sodium nitrite (717 mg, 10.4 mmol) dissolved in water (4 mL) was added dropwise to the above reaction mixture under ice bath conditions with continuous stirring for 1 hour. Subsequently, a pre-cooled solution of concentrated hydrochloric acid (2 mL) of stannous chloride (4.7 g, 20.8 mmol) was slowly added to the diazo reaction mixture. The reaction mixture was continued to be stirred at 0°C for 2 hours. Upon completion of the reaction, the resulting yellow-orange precipitate was collected and washed thoroughly with ice-cold water until the filtrate was neutral (pH ≈ 7). Finally, the precipitate was dried under vacuum conditions overnight to afford the target product 4-nitrophenylhydrazine hydrochloride (640 mg, 4.18 mmol, 39% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 4.49 (s, 2H), 6.78 (d, J=8.78 Hz, 2H), 7.98 (d, J=9.29 Hz, 2H), 8.41 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 9, p. 2739 - 2752
[2] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[4] Journal of Agricultural and Food Chemistry, 2014, vol. 62, # 2, p. 381 - 390
[5] Oriental Journal of Chemistry, 2017, vol. 33, # 2, p. 1041 - 1044
4-Nitrophenylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Buddy Chemical Technology Co., Ltd. | 18351236123 | buddychem@foxmail.com | China | 232 | 58 |
| Nantong Haigine Pharma Technology Co., Ltd | 0513-86266699-8010 19040080082 | sales@haigine.com | China | 71 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from 4-Nitrophenylhydrazine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Nitrophenylhydrazine hydrochloride
636-99-7
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 4-Nitrophenylhydrazine hydrochloride
636-99-7
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-02-26 | 4-Nitrophenylhydrazine Hydrochloride
636-99-7
|
1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Nitrophenylhydrazine hydrochloride
636-99-7
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Nitrophenylhydrazine hydrochloride
636-99-7
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Nitrophenylhydrazine Hydrochloride
636-99-7
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
636-99-7(4-Nitrophenylhydrazine hydrochloride )Related Search:
1of3
