N1-(4-Acetyl-3-hydroxyphenyl)acetamide
- CAS No.
- 40547-58-8
- Chemical Name:
- N1-(4-Acetyl-3-hydroxyphenyl)acetamide
- Synonyms
- N-(4-Acetyl-3-hydroxyphenyl);4'-ACETAMIDO-2'-HYDROXYACETOPHENONE;N-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE;N1-(4-Acetyl-3-hydroxyphenyl)acetamide;AcetaMide, N-(4-acetyl-3-hydroxyphenyl)-;N1-(4-Acetyl-3-hydroxyphenyl)acetamide, Tech.;JR-8565, 4'-Acetamido-2'-hydroxyacetophenone, 97%
- CBNumber:
- CB4684756
- Molecular Formula:
- C10H11NO3
- Molecular Weight:
- 193.2
- MDL Number:
- MFCD00026134
- MOL File:
- 40547-58-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| NFPA 704 |
|
N1-(4-Acetyl-3-hydroxyphenyl)acetamide price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 261127 | 4'-Acetamido-2'-hydroxyacetophenone Asreported | 40547-58-8 | 250mg | $336 | 2026-06-03 | Buy |
| Usbiological | 261127 | 4'-Acetamido-2'-hydroxyacetophenone Asreported | 40547-58-8 | 500mg | $460 | 2026-06-03 | Buy |
| Usbiological | 261127 | 4'-Acetamido-2'-hydroxyacetophenone Asreported | 40547-58-8 | 1g | $807 | 2026-06-03 | Buy |
| Usbiological | 261127 | 4'-Acetamido-2'-hydroxyacetophenone Asreported | 40547-58-8 | 2g | $1128 | 2026-06-03 | Buy |
| Usbiological | 261127 | 4'-Acetamido-2'-hydroxyacetophenone Asreported | 40547-58-8 | 5g | $1600 | 2026-06-03 | Buy |
N1-(4-Acetyl-3-hydroxyphenyl)acetamide Chemical Properties, Uses, Production
Synthesis
75-36-5
588-16-9
40547-58-8
Step 2: Preparation of 4-acetamido-2-hydroxyacetophenone N-(4-acetyl-3-hydroxyphenyl)acetamide was prepared based on the improved method of Elliott, J.M. et al. (J. Med. Chem., 1992, 35, 3973-3976): over 20 min, aluminum chloride (27 g, 206 mmol) was added batchwise to mechanically stirred 3'-methoxyacetanilide (10 g, 60.5 mmol), acetyl chloride (12.5 mL, 175.6 mmol) and dichloromethane (25 mL) mixture. Upon completion of the reaction, all dichloromethane was removed by distillation and the resulting viscous mixture was left to heat at 80°C for 3.5 hours. Subsequently, chlorobenzene (60 mL) was added and the mixture was heated to reflux (132°C) and stirred under reflux conditions for 1 hour. The reaction mixture was cooled to 0°C and crushed ice was slowly added while stirring. The resulting solid product was collected by filtration and purified by silica gel column chromatography to afford N-(4-acetyl-3-hydroxyphenyl)acetamide 7.34 g (63% yield). 1H NMR (400 MHz, DMSO-d6): δ 12.31 (s, 1H), 10.26 (s, 1H), 7.83 (d, J = 8.8 Hz, 1H), 7.34 (d, J = 1.8 Hz, 1H), 7.05 (dd, J = 8.8, 1.8 Hz, 1H), 2.56 (s, 3H), 2.08 (s, 3H) . MS-APCI (m/z +): 194 (M + 1).
References
[1] Patent: WO2007/88438, 2007, A2. Location in patent: Page/Page column 17
[2] Journal of the Chemical Society, 1958, p. 146,149
[3] Journal of the Chemical Society, 1931, p. 2388,2406
[4] Bulletin de la Societe Chimique de France, 1952, p. 639
[5] Patent: US5622989, 1997, A
N1-(4-Acetyl-3-hydroxyphenyl)acetamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
N1-(4-Acetyl-3-hydroxyphenyl)acetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2976 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20535 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
View Latest Price from N1-(4-Acetyl-3-hydroxyphenyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE
40547-58-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
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- N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE
40547-58-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
