N1-(3-Acetyl-4-hydroxyphenyl)acetamide
- CAS No.
- 7298-67-1
- Chemical Name:
- N1-(3-Acetyl-4-hydroxyphenyl)acetamide
- Synonyms
- N-(3-AcetyL;3'-Acetyl-4'-hydroxyacetanilide;5'-Acetamido-2'-hydroxyacetophenone;5'-Acetamido-2'-hydroxypropiophenone;N-(3-acetyl-4-hydroxyphenyl)acetamide;5'-AcetylaMino-2'-hydroxyacetophenone;N1-(3-Acetyl-4-hydroxyphenyl)acetamide;5'-AcetylaMino-2'- hydroxyacetophenone;5'-Acetamido-2'-hydroxyacetophenone >Acetamide, N-(3-acetyl-4-hydroxyphenyl)-
- CBNumber:
- CB8102014
- Molecular Formula:
- C10H11NO3
- Molecular Weight:
- 193.2
- MDL Number:
- MFCD00100490
- MOL File:
- 7298-67-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| HS Code | 2924297099 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
N1-(3-Acetyl-4-hydroxyphenyl)acetamide price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2698 | 5'-Acetamido-2'-hydroxyacetophenone >98.0%(HPLC)(T) | 7298-67-1 | 1g | $43 | 2026-04-30 | Buy |
| TCI Chemical | A2698 | 5'-Acetamido-2'-hydroxyacetophenone >98.0%(HPLC)(T) | 7298-67-1 | 5g | $146 | 2026-04-30 | Buy |
| Usbiological | 457012 | N-(3-Acetyl-4-hydroxyphenyl)acetamide | 7298-67-1 | 100mg | $312 | 2026-06-03 | Buy |
| Usbiological | 457012 | N-(3-Acetyl-4-hydroxyphenyl)acetamide | 7298-67-1 | 250mg | $396 | 2026-06-03 | Buy |
| TRC | TRC-A178970-250MG | N-(3-Acetyl-4-hydroxyphenyl)acetamide | 7298-67-1 | 250mg | $78 | 2026-06-03 | Buy |
N1-(3-Acetyl-4-hydroxyphenyl)acetamide Chemical Properties, Uses, Production
Uses
N-(3-Acetyl-4-hydroxyphenyl)acetamide is a useful synthetic intermediate in the synthesis of rac Diacetolol (D305200); the principal metabolite of Acebutolol (A123800) with less β-adrenoceptor blocking potency but greater cardioselectivity (atrial relative to tracheal tissue).
Synthesis
51-66-1
75-36-5
7298-67-1
General procedure for the synthesis of 2-hydroxy-5-acetamidoacetophenone from 4-methoxyacetanilide and acetyl chloride: acetyl chloride (25 mL, 0.352 mol) was slowly added dropwise to a stirred suspension of 4-methoxyacetanilide (20 g, 0.121 mol) in carbon disulfide (50 mL). Anhydrous aluminum chloride (55 g, 0.412 mol) was then added in batches. The reaction mixture was heated and stirred at 80-90°C for 90 minutes. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into a mixture of crushed ice and water. The precipitated solid was collected by filtration and washed well with water. The crude product was dissolved in 5% (w/v) aqueous sodium hydroxide solution and the solution was filtered through Celite. The filtrate was acidified to pH 1 with concentrated hydrochloric acid to precipitate 2-hydroxy-5-acetamidoacetophenone. The product was collected by filtration, washed with water and dried to give a white solid (21.05 g, 90% yield): melting point 162-164°C; IR (KBr)ν: 3452 cm-1 (O-H stretching vibration), 1657 cm-1 (C=O stretching vibration); 1H NMR (DMSO-d6, 500 MHz): δ 2.02 (s, 3H, - NHCOCH3), 2.58 (s, 3H, -COCH3), 6.90 (d, 1H, 5-H), 7.65 (dd, 1H, 6-H), 8.06 (s, 1H, 2-H), 9.89 (s, 1H, -NHCOCH3), 11.54 (s, 1H, -OH). Elemental analysis (C10H11NO3) calculated values: C, 62.17; H, 5.74; N, 7.25. measured values: C, 62.35; H, 5.82; N, 7.19.
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 13, p. 3919 - 3928
[2] Patent: WO2012/107262, 2012, A1. Location in patent: Page/Page column 29
[3] Journal of Organic Chemistry, 1995, vol. 60, # 14, p. 4324 - 4330
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 21, p. 3973 - 3976
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2079 - 2098
N1-(3-Acetyl-4-hydroxyphenyl)acetamide Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ChangShu Haitian Fine Chemicals Co.,Ltd | 13913622609 | 974295387@qq.com | China | 192 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| ChangZhou SIDU chemical Co., Ltd. | 0519-81291281 18015082300 | siduchem@hotmail.com | China | 274 | 62 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from N1-(3-Acetyl-4-hydroxyphenyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE
7298-67-1
|
$1.00 | 1KG | 98% | 10 tons | Career Henan Chemical Co |
-
- N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE
7298-67-1
- $1.00
- 98%
- Career Henan Chemical Co
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