Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Structure
4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE structure
CAS No.
56843-79-9
Chemical Name:
4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE
Synonyms
Propanoicacid,2-(9-nitrophenoxy)-;4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDIN;4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE;Thieno[2,3-d]pyrimidine, 4-chloro-2-methyl-;3-Pyridinecarboxylicacid,2,9-dimethyl-,methylester;4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber:
CB4702924
Molecular Formula:
C7H5ClN2S
Molecular Weight:
184.65
MDL Number:
MFCD03028468
MOL File:
56843-79-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:52
Request For Quotation

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Properties

Melting point 90 - 92°C
Boiling point 208.1±22.0 °C(Predicted)
Density 1.445±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 0.87±0.40(Predicted)
color Beige
InChI InChI=1S/C7H5ClN2S/c1-4-9-6(8)5-2-3-11-7(5)10-4/h2-3H,1H3
InChIKey VYUDXHRVZLZWMP-UHFFFAOYSA-N
SMILES C1(C)=NC(Cl)=C2C=CSC2=N1

SAFETY

Risk and Safety Statements

HS Code  2934999090

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C368935 4-Chloro-2-methylthieno[2,3-d]pyrimidine 56843-79-9 50mg $75 2021-12-16 Buy
Biosynth Carbosynth FC148754 4-Chloro-2-methyl-thieno[2,3-d]pyrimidine 56843-79-9 50mg $94 2021-12-16 Buy
Biosynth Carbosynth FC148754 4-Chloro-2-methyl-thieno[2,3-d]pyrimidine 56843-79-9 100mg $164 2021-12-16 Buy
Apolloscientific OR932569 4-Chloro-2-methylthieno[2,3-d]pyrimidine 95% 56843-79-9 250mg $250 2021-12-16 Buy
AK Scientific X0261 4-Chloro-2-methylthieno[2,3-d]pyrimidine 56843-79-9 1g $314 2021-12-16 Buy
Product number Packaging Price Buy
C368935 50mg $75 Buy
FC148754 50mg $94 Buy
FC148754 100mg $164 Buy
OR932569 250mg $250 Buy
X0261 1g $314 Buy

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Chemical Properties,Uses,Production

Synthesis

2-methylthieno[2,3-d]pyrimidin-4(3H)-one

21582-51-4

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE

56843-79-9

The general procedure for the synthesis of 4-chloro-2-methylthieno[2,3-D]pyrimidines from 4-hydroxy-2-methylthieno[2,3-D]pyrimidines was as follows: a few drops of pyridine were added to a solution of 2-methylthieno[2,3-d]pyrimidin-4(3H)-one (300 mg, 1.80 mmol) in phosphorus oxychloride (POCl3, 5.0 mL). The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. Subsequently, saturated sodium carbonate (Na2CO3) solution was added to neutralize the excess trichlorophosphate. The aqueous phase was extracted with ethyl acetate (EtOAc) and the organic phase was combined. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (8:2, v/v) to afford the target compound 4-chloro-2-methylthieno[2,3-D]pyrimidine in 61% yield. The product was a yellow solid with a melting point of 93 °C. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 200 MHz, CDCl3) δ= 7.48 (d, J = 6.0 Hz, 1H), 7.35 (d, J = 6.0 Hz, 1H), 2.79 (s, 3H). Nuclear magnetic resonance carbon spectrum (13C NMR, 50 MHz, CDCl3) δ= 169.2, 163.0, 154.4, 126.8, 126.6, 119.5, 25.5. liquid chromatography-mass spectrometry (LC-MS, ESI, 35 eV): retention time (tR) = 1.84 min, mass-to-charge ratio (m/z) = 185 [M + H]+ The results are summarized in the following table.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 68 - 86

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

2-methylthieno[2,3-d]pyrimidin-4(3H)-one

Preparation Products

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Worldyang Chemical Co.,Ltd. 		+86-021-56795779 +8613651600618 sales@worldyachem.com China 1382 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14360 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7951 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20342 58
Supplier Advantage
Shanghai Worldyang Chemical Co.,Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
CD Chemical Group Limited 		58

View Lastest Price from 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE pictures 2025-06-25 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE
56843-79-9
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Spectrum

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE(56843-79-9)1HNMR

56843-79-9(4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE)Related Search:

4-CHLORO-2,5,6-TRIMETHYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2,5-DIPHENYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE 2-chloro-5-methylthieno[2,3-d]pyrimidine
2-Methylthiophene 4-CHLORO-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE ETHYL 4-CHLORO-2,5-DIMETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE 4-CHLORO-2-METHYL-5-PHENYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-METHYL-6-PHENYL-THIENO[2,3-D]PYRIMIDINE
4-CHLORO-2,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-ETHYL-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-METHYL-2,3-DIHYDRO-1H-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE METHYL 4-CHLORO-5-METHYL-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
4-CHLORO-2-(CHLOROMETHYL)-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE METHYL TRANS-4-(4-CHLORO-[1]BENZOTHIENO[2,3-D]-PYRIMIDIN-2-YL)-CYCLOHEXANECARBOXYLATE 4-CHLORO-2-(MORPHOLIN-4-YLMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

1of4

4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDIN 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH 3-Pyridinecarboxylicacid,2,9-dimethyl-,methylester Propanoicacid,2-(9-nitrophenoxy)- Thieno[2,3-d]pyrimidine, 4-chloro-2-methyl- 56843-79-9 Heterocycle-Pyrimidine series pyrimidine