SB 221284
- CAS No.
- 196965-14-7
- Chemical Name:
- SB 221284
- Synonyms
- SB 221284;5-(METHYLTHIO)-1-(3-PYRIDYLCARBAMOYL)-6-(TRIFLUOROMETHYL)INDOLINE;2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;1H-Indole-1-carboxamide, 2,3-dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-
- CBNumber:
- CB4704933
- Molecular Formula:
- C16H14F3N3OS
- Molecular Weight:
- 353.36
- MDL Number:
- MFCD00950075
- MOL File:
- 196965-14-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SB 221284 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 465898 | SB 221284 | 196965-14-7 | 5mg | $475 | 2026-06-03 | Buy |
| Usbiological | 465898 | SB 221284 | 196965-14-7 | 10mg | $679 | 2026-06-03 | Buy |
| ApexBio Technology | B6713 | SB 221284 | 196965-14-7 | 10mg | $197 | 2026-05-06 | Buy |
| ApexBio Technology | B6713 | SB 221284 | 196965-14-7 | 50mg | $825 | 2026-05-06 | Buy |
| AHH | MT-09746 | 2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-(1H)indole-1-carboxamide 97% | 0.025g | $446 | 2026-05-26 | Buy |
SB 221284 Chemical Properties, Uses, Production
Uses
SB 221284 is a potent, selective SR-2C/SR-2B antagonist.
Definition
ChEBI: SB 221284 is an indolyl carboxylic acid.
Biological Activity
Potent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .
in vivo
SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]
| Animal Model: | Male Sprague Dawley rats (250–360 g)[1] |
| Dosage: | 0.1~1 mg/kg |
| Administration: | I.p. |
| Result: | Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801. |
| Animal Model: | Male Sprague Dawley rats (250–360 g)[1] |
| Dosage: | 1 mg/kg |
| Administration: | I.p. |
| Result: | Significantly enhanced the magnitude and duration of the increase induced by phencyclidine. |
IC 50
5-HT2A Receptor: 6.4 (pKi); 5-HT2B Receptor: 7.9 (pKi); 5-HT2C Receptor: 8.6 (pKi)
SB 221284 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 221284 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
