ChemicalBook >> CAS DataBase List >>5'-CHLORO-5'-DEOXYADENOSINE

5'-CHLORO-5'-DEOXYADENOSINE

5'-CHLORO-5'-DEOXYADENOSINE structure

CAS No.: 892-48-8

Chemical Name:: 5'-CHLORO-5'-DEOXYADENOSINE

Synonyms: Ribavirin Impurity 63;5'-Cl-5'-deoxyadenosine;5'-Chloro-5'-deoxyadenosin;5’-chloro-5’-deoxy-adenosin;5'-CHLORO-5'-DEOXYADENOSINE;5'-Deoxy-5'-chloroadenosine;Adenosine,5'-chloro-5'-deoxy-;5'-CHLORO-5'-DEOXY-D-ADENOSINE;5-CHLORO-5-DEOXYADENOSINE HYDRATE;5'-CHLORO-5'-DEOXYADENOSINE USP/EP/BP

CBNumber:: CB4706654

Molecular Formula:: C10H12ClN5O3

Molecular Weight:: 285.69

MDL Number:: MFCD00049038

MOL File:: 892-48-8.mol

Last updated:2025-07-24 18:13:52

Request For Quotation

5'-CHLORO-5'-DEOXYADENOSINE Properties

Melting point	187 °C (exothermic decomp onset @144.5 C)(lit.)
Boiling point	645.6±65.0 °C(Predicted)
Density	2.03±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Slightly), Water (Slightly, Heated)
form	Solid
pka	13.03±0.70(Predicted)
color	Off-White to Light Beige
InChI	InChI=1S/C10H12ClN5O3/c11-1-4-6(17)7(18)10(19-4)16-3-15-5-8(12)13-2-14-9(5)16/h2-4,6-7,10,17-18H,1H2,(H2,12,13,14)/t4-,6-,7-,10-/m1/s1
InChIKey	IYSNPOMTKFZDHZ-KQYNXXCUSA-N
SMILES	C(Cl)[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
RTECS	AU7357200

5'-CHLORO-5'-DEOXYADENOSINE price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C3773	5'-Chloro-5'-deoxyadenosine	892-48-8	5G	$71	2025-07-31	Buy
TCI Chemical	C3773	5'-Chloro-5'-deoxyadenosine	892-48-8	25G	$213	2025-07-31	Buy
TRC	D232545	5''-Deoxy-5''-chloroadenosine	892-48-8	25g	$195	2021-12-16	Buy
Usbiological	295588	5'-Chloro-5'-deoxyadenosine	892-48-8	5g	$337	2021-12-16	Buy
TRC	D232545	5''-Deoxy-5''-chloroadenosine	892-48-8	100g	$610	2021-12-16	Buy

Product number	Packaging	Price	Buy
C3773	5G	$71	Buy
C3773	25G	$213	Buy
D232545	25g	$195	Buy
295588	5g	$337	Buy
D232545	100g	$610	Buy

5'-CHLORO-5'-DEOXYADENOSINE Chemical Properties,Uses,Production

Uses

5''-Deoxy-5''-chloroadenosine is an intermediate in the synthesis of 5''-Deoxy-5''-(methylthio)adenosine (D242600), a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.

Definition

ChEBI: 5'-chloro-5'-deoxyadenosine is a member of adenosines. It is functionally related to an adenosine.

Synthesis

58-61-7

892-48-8

General steps: 1. Preparation of (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(chloromethyl) tetrahydrofuran-3,4-diol Under ice bath cooling conditions, (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (1 g, 3.47 mmol) was dissolved in acetonitrile (10 ml), pyridine (593 mg, 0.6 ml, 7.49 mmol) and SOCl2 (2.22 g, 1.36 ml, 18.65 mmol). The reaction mixture was stirred at 0-5 °C for 3-4 h, followed by slow warming to room temperature and stirring overnight. After completion of the reaction, the suspension was concentrated in vacuum. Methanol (20 ml), water (2 ml) and NH4OH (4 ml) were added to the concentrate and stirred for 0.5 h at room temperature. The reaction mixture was again concentrated to dryness. The crude product was dissolved in methanol, silica gel (3 g) was added and the solvent was subsequently removed. The residue was purified by silica gel column chromatography (SGC) using gradient elution with ethyl acetate:methanol (0%-10%) to afford the target compound (0.915 g, 86% yield) as a light yellow solid. NMR (500 MHz, MeOD): δ 8.24 (s, 1H), 8.02 (s, 1H), 7.27-7.20 (m, 5H), 6.19 (d, J = 2.0 Hz, 1H), 5.48-5.46 (m, 1H), 5.08-5.06 (m, 1H), 4.43 (t, J = 4.0 Hz, 1H), 3.83 -3.81 (m, 2H), 3.01-2.99 (br s, 2H), 1.60 (s, 3H), 1.38 (s, 3H) ppm. LCMS (m/z): 395.8 [M + H]+.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 18, p. 8066 - 8074,9
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 46, p. 14277 - 14280
[3] Angew. Chem., 2016, vol. 128, # 46, p. 14489 - 14492,4
[4] Tetrahedron Letters, 2018, vol. 59, # 4, p. 415 - 417
[5] Patent: US4373097, 1983, A

5'-CHLORO-5'-DEOXYADENOSINE Preparation Products And Raw materials

Raw materials

Adenosine Thionyl chloride Pyridine Ammonium hydroxide

Preparation Products

5'-DEOXY-5'-METHYLTHIOADENOSINE 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE S-adenosyl-3-thiopropylamine 5'-deoxy-5'-fluoroadenosine S-ADENOSYL-L-CYSTEINE

5'-CHLORO-5'-DEOXYADENOSINE Suppliers

Global( 151)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mujin Biotechnology Co.,Ltd	+8613288715578	sales@hbmojin.com	China	12399	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Hebei Mujin Biotechnology Co.,Ltd	58
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Changzhou Carman Chemical Co., Ltd.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 5'-CHLORO-5'-DEOXYADENOSINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-08	5'-CHLORO-5'-DEOXYADENOSINE 892-48-8	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2025-05-30	5'-CHLORO-5'-DEOXYADENOSINE 892-48-8	US $0.00-0.00 / G	1G	97%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2025-04-04	5'-Chloro-5'-deoxy-D-adenosine 892-48-8	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

5'-CHLORO-5'-DEOXYADENOSINE
892-48-8
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

5'-CHLORO-5'-DEOXYADENOSINE
892-48-8
US $0.00-0.00 / G
97%
Shenzhen Nexcon Pharmatechs Ltd.

5'-Chloro-5'-deoxy-D-adenosine
892-48-8
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

5'-CHLORO-5'-DEOXYADENOSINE Spectrum

5'-CHLORO-5'-DEOXYADENOSINE(892-48-8)¹HNMR

892-48-8(5'-CHLORO-5'-DEOXYADENOSINE)Related Search:

4-Chloro-1-butanol Adenine Sulfate Adenine hydrochloride hemihydrate Adenine hydrochloride (S)-1-Chloro-2-propanol

Tetrahydrofurfuryl chloride (S)-(+)-3-Chloro-1,2-propanediol 2-(2-Chloroethoxy)ethanol 1-(2-Chloroethoxy)propane 5-Chloropentanol

3-Chloro-1,2-propanediol 2-CHLORO-2'-DEOXYADENOSINE,CLADRIBINE [2-CHLORO-2''-DEOXYADENOSINE],2-CHLORO-2''-DEOXYADENOSINE (CDA: CLADRIBINE) 5-CHLOROPENTYLAMINE (S)-3-AMINO-1,2-DIHYDROXYPROPANE HYDROCHLORIDE 5'-CHLORO-5'-DEOXYADENOSINE

8-CHLORO-2'-DEOXYADENOSINE 2-chloro-3'-deoxyadenosine 2-CHLORO-2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, TETRALITHIUM SALT

1of4

5'-CHLORO-5'-DEOXYADENOSINE 5-CHLORO-5-DEOXYADENOSINE HYDRATE 5'-CHLORO-5'-DEOXYADENOSINE MONOHYDRATE 5’-chloro-5’-deoxy-adenosin 5'-CHLORO-5'-DEOXY-D-ADENOSINE 5'-Deoxy-5'-chloroadenosine 5'-Cl-5'-deoxyadenosine Adenosine,5'-chloro-5'-deoxy- 9-(5-chloro-5-deoxypentofuranosyl)-9H-purin-6-amine Ribavirin Impurity 63 5'-CHLORO-5'-DEOXYADENOSINE USP/EP/BP 5'-Chloro-5'-deoxyadenosin 892-48-8 Specialty Synthesis Oligonucleotide Synthesis Nucleosides