4-Benzyloxy-5-methoxy-2-nitro-benzoic acid
- CAS No.
- 60547-92-4
- Chemical Name:
- 4-Benzyloxy-5-methoxy-2-nitro-benzoic acid
- Synonyms
- 2-(Benzyloxy)-5-carboxy-4-nitroansole;4-Benzyloxy-3-Methoxy-6-nitrobenzoic acid;4-Benzyloxy-5-methoxy-2-nitro-benzoic acid;2-Nitro-4-(benzyloxy)-5-methoxybenzoic acid;5-Methoxy-2-nitro-4-(phenylMethyloxy)benzoic acid;Benzoic acid, 5-Methoxy-2-nitro-4-(phenylMethoxy)-;2-(Benzyloxy)-5-carboxy-4-nitroansole, 5-(Benzyloxy)-2-carboxy-4-methoxynitroben;2-(Benzyloxy)-5-carboxy-4-nitroansole, 5-(Benzyloxy)-2-carboxy-4-methoxynitrobenzene
- CBNumber:
- CB4707686
- Molecular Formula:
- C15H13NO6
- Molecular Weight:
- 303.27
- MDL Number:
- MFCD04114356
- MOL File:
- 60547-92-4.mol
- MSDS File:
- SDS
| Melting point | 192 °C |
|---|---|
| Boiling point | 504.4±50.0 °C(Predicted) |
| Density | 1.362±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 2.34±0.25(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C15H13NO6/c1-21-13-7-11(15(17)18)12(16(19)20)8-14(13)22-9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,17,18) |
| InChIKey | VTHHRADLOLKTLD-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(OC)=C(OCC2=CC=CC=C2)C=C1[N+]([O-])=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| HS Code | 2921490090 |
4-Benzyloxy-5-methoxy-2-nitro-benzoic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | KCA54792 | 4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid | 60547-92-4 | 0.25g | $250 | 2026-06-04 | Buy |
| Biosynth | KCA54792 | 4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid | 60547-92-4 | 2.5g | $855.5 | 2026-06-04 | Buy |
| Apolloscientific | OR17006 | 4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid >98% | 60547-92-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR17006 | 4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid >98% | 60547-92-4 | 25g | $40 | 2026-06-04 | Buy |
| Apolloscientific | OR17006 | 4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid >98% | 60547-92-4 | 100g | $147 | 2026-06-04 | Buy |
4-Benzyloxy-5-methoxy-2-nitro-benzoic acid Chemical Properties, Uses, Production
Uses
4-(Benzyloxy)-5-methoxy-2-nitrobenzoic Acid is a reagent used in the preparation of benzodiazepine-based β-glucoside prodrugs for use in cancer chemotherapy.
Synthesis
2426-84-8
60547-92-4
General procedure for the synthesis of 2-nitro-4-benzyloxy-5-methoxybenzoic acid from 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde: 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (20 g, 69.62 mmol) was dissolved in acetone (200 mL), and preheated 10% potassium permanganate solution was added slowly at 30 °C. The reaction mixture was stirred at 50 °C for 2 h and then cooled to room temperature. Subsequently, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with acetone and a little hot water. The filtrate was concentrated under reduced pressure and cooled to 0°C. The concentrate was acidified to pH 4 with hydrochloric acid, stirred for 30 min and filtered to give a solid product of 2-nitro-4-benzyloxy-5-methoxybenzoic acid (18.5 g, 88% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, DMSO-d6): δ 13.58 (brs, 1H), 7.70 (s, 1H), 7.46-7.40 (m, 6H), 7.39 (s, 1H), 5.25 (s, 2H), 3.92 (s, 3H). Mass spectrum (ESI+, m/z): 304 [M+H]+.
References
[1] Patent: WO2012/30160, 2012, A2. Location in patent: Page/Page column 50
[2] Patent: WO2017/194960, 2017, A1. Location in patent: Page/Page column 187
[3] Patent: US4950674, 1990, A
[4] Farmaco, Edizione Scientifica, 1977, vol. 32, # 8, p. 579 - 591
[5] Tetrahedron Letters, 1986, vol. 27, # 10, p. 1149 - 1152
4-Benzyloxy-5-methoxy-2-nitro-benzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Weifang Ding Hong Pharmaceutical Technology Co., Ltd. | 18663683121 | dhpharm@163.com | China | 33 | 58 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1997 | 55 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 695 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
View Latest Price from 4-Benzyloxy-5-methoxy-2-nitro-benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-20 | 4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID
60547-92-4
|
1kg | 98.0%min | 100kg | LY Global chemicals co.,ltd . | ||
 |
2019-07-10 | 4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID
60547-92-4
|
$3.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID
60547-92-4
- $0.00
- 98.0%min
- LY Global chemicals co.,ltd .
-
- 4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID
60547-92-4
- $3.00
- 99%
- Career Henan Chemical Co
60547-92-4 (4-Benzyloxy-5-methoxy-2-nitro-benzoic acid) Related Search:
1of3
