Vanillic acid
- CAS No.
- 121-34-6
- Chemical Name:
- Vanillic acid
- Synonyms
- VA;4-HYDROXY-3-METHOXYBENZOIC ACID;Benzoic acid, 4-hydroxy-3-methoxy-;Vanilic acid;vanillic;3-Methoxy-4-Hydroxybenzoic acid;Magnolioside;Vanillate;Vanilloid;Vallinic acid
- CBNumber:
- CB2449434
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00002551
- MOL File:
- 121-34-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Vanillic acid ≥97%, FG | W398802 | 1 each | $58 |
| Vanillic acid ≥97%, FG | W398802 | 1kg | $595 |
| Vanillic acid ≥97%, FG | W398802 | 10Kg | $4040 |
| Vanillic acid phyproof? Reference Substance | PHL89819 | 100MG | $247 |
| Vanillic acid purum, ≥97.0% (HPLC) | 94770 | 10g | $28.5 |
| More product size | |||
| Melting point | 208-210 °C(lit.) |
|---|---|
| Boiling point | 257.07°C (rough estimate) |
| Density | 1.3037 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| FEMA | 3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID |
| FLAVIS Number | 08.043 | Vanillic acid |
| storage temp. | Store below +30°C. |
| solubility | Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly） |
| pka | pKa 4.53(H2O t = 25 c = 0.016–0.001) (Uncertain) |
| form | Liquid |
| color | Clear colorless to brown, may darken during storage |
| Odor | at 100.00 %. dairy milky custard creamy powdery vanilla bean |
| Odor Type | creamy |
| biological source | synthetic |
| Water Solubility | Soluble in water, alcohol and ether. |
| JECFA Number | 959 |
| Merck | 14,9931 |
| BRN | 2208364 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | 1S/C8H8O4/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,9H,1H3,(H,10,11) |
| InChIKey | WKOLLVMJNQIZCI-UHFFFAOYSA-N |
| SMILES | COc1cc(ccc1O)C(O)=O |
| LogP | 1.30 |
| CAS DataBase Reference | 121-34-6(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | VANILLIC ACID |
| EWG's Food Scores | 1 |
| FDA UNII | GM8Q3JM2Y8 |
| NIST Chemistry Reference | Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6) |
| EPA Substance Registry System | Vanillic acid (121-34-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | YW5300000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29189090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Vanillic acid price More Price(107)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W398802 | Vanillic acid ≥97%, FG | 121-34-6 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W398802 | Vanillic acid ≥97%, FG | 121-34-6 | 1kg | $595 | 2026-04-30 | Buy |
| Sigma-Aldrich | W398802 | Vanillic acid ≥97%, FG | 121-34-6 | 10Kg | $4040 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL89819 | Vanillic acid phyproof? Reference Substance | 121-34-6 | 100MG | $247 | 2026-04-30 | Buy |
| Sigma-Aldrich | 94770 | Vanillic acid purum, ≥97.0% (HPLC) | 121-34-6 | 10g | $28.5 | 2026-04-30 | Buy |
Vanillic acid Chemical Properties,Uses,Production
Description
Vanillic acid is a dihydroxybenzoic acid that can be used as a flavoring agent. As an oxidized form of vanillin, it is the intermediate product during the two-step bioconversion process from ferulic acid to vanillin. It exists in high amount in the root of Angelica sinenisis, which is a plant used in traditional Chinese medicine. It also exists in acal oil, argan oil as well as wine and vinegar. It can be used in the synthesis of the analeptic drug etamivan, modecainide, brovanexine, vanitiolide, and vanyldisulfamide. It can be manufactured through the oxidation of vanillin to the carboxylic acid.
References
https://en.wikipedia.org/wiki/Vanillic_acid
https://pubchem.ncbi.nlm.nih.gov/compound/Vanillic_acid#section=Top
Chemical Properties
white odourless crystals or powder
Chemical Properties
4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste.
Occurrence
Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries.
Uses
Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent.
Uses
A flavoring agent.
Uses
Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar.
Preparation
Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus
Definition
ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.
Aroma threshold values
Aroma at 5.0%: weak vanilla, creamy, milky.
Taste threshold values
Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025
Organic Syntheses, Coll. Vol. 4, p. 972, 1963
General Description
Vanillic acid is one of the key aromatic volatile compounds of vanilla beans.
Biochem/physiol Actions
Taste at 100 ppm
Vanillic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huanfu Industrial Co.，（Shanghai）Ltd. | +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 661 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
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View Lastest Price from Vanillic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Vanillic acid
121-34-6
|
$5.00 | 1kg | ≥98% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-07-09 | Vanillic acid
121-34-6
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | Vanillic acid
121-34-6
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Vanillic acid
121-34-6
- $5.00
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- Vanillic acid
121-34-6
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Vanillic acid
121-34-6
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
