ChemicalBook >> CAS DataBase List >>4alpha-Phorbol 12-myristate 13-acetate
4alpha-Phorbol 12-myristate 13-acetate
- CAS No.
- 63597-44-4
- Chemical Name:
- 4alpha-Phorbol 12-myristate 13-acetate
- Synonyms
- 4α-TPA;4α-pma;alpha-TPA;4ALPHA-PMA;4ALPHA-TPA;4-alpha-PMA, 4-alpha-TPA;4α-Phorbol 12-myristate 13-acetate;4a-Phorbol 12-Myristate 13-Acetate;4alpha-Phorbol 12-myristate 13-acetate;4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
- CBNumber:
- CB4748443
- Molecular Formula:
- C36H56O8
- Molecular Weight:
- 616.83
- MDL Number:
- MFCD00153860
- MOL File:
- 63597-44-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-09-12 18:52:57
| storage temp. | -20°C |
|---|---|
| solubility | H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. |
| form | solid |
| color | white |
| Water Solubility |
H2O: ~2μM DMSO: soluble ethanol: soluble |
| Sensitive | Light Sensitive |
| InChIKey | PHEDXBVPIONUQT-LQLWEASQSA-N |
| SMILES | CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| F | 10-21 |
| Storage Class | 11 - Combustible Solids |
4alpha-Phorbol 12-myristate 13-acetate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P148 | 4α-Phorbol 12-myristate 13-acetate solid, ≥95% (TLC) | 63597-44-4 | 1mg | $306 | 2026-04-30 | Buy |
| Cayman Chemical | 16806 | 4α-Phorbol 12-myristate 13-acetate ≥98% | 63597-44-4 | 1mg | $81 | 2026-04-30 | Buy |
| TRC | TRC-P353485-2.5MG | 4Alpha-Phorbol 12-Myristate 13-Acetate | 63597-44-4 | 2.5mg | $384 | 2026-06-03 | Buy |
| ChemScene | CS-0024660 | 4α-TPA 99.0% | 63597-44-4 | 1mg | $184 | 2026-06-04 | Buy |
| Adipogen Life Sciences | AG-CN2-0082-M001 | 4α-Phorbol 12-myristate 13-acetate ≥98%(HPLC) | 63597-44-4 | 1mg | $80 | 2026-05-06 | Buy |
4alpha-Phorbol 12-myristate 13-acetate Chemical Properties,Uses,Production
Uses
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
4alpha-Phorbol 12-myristate 13-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
4alpha-Phorbol 12-myristate 13-acetate Suppliers
Global( 42)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 | 359382369@qq.com | China | 10667 | 58 |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | 1986399151@qq.com | China | 9839 | 58 |
63597-44-4(4alpha-Phorbol 12-myristate 13-acetate)Related Search:
4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
4α-pma
4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
4α-TPA
4-alpha-Phorbol 12-Myristate 13-Acetate >99%
4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
4-alpha-PMA, 4-alpha-TPA
4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
4ALPHA-PMA
4ALPHA-TPA
Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
alpha-TPA
4α-Phorbol 12-myristate 13-acetate
4a-Phorbol 12-Myristate 13-Acetate
4alpha-Phorbol 12-myristate 13-acetate
63597-44-4
Serine/Threonine Kinase Activators
Protein Kinase C (PKC)
Kinase/Phosphatase Biology
Cell Signaling and Neuroscience
Cell Biology
BioChemical
metabolite
