2,5-Dichloro-4-formylpyridine
- CAS No.
- 102645-33-0
- Chemical Name:
- 2,5-Dichloro-4-formylpyridine
- Synonyms
- 2,5-DICHLORO-4-FORMY;2,5-Dichloro-4-formylpyridine;2,5-Dichloroisonicotinaldehyde 97%;2,5-Dichloro-4-pyridinecarbaldehyde;2,5-dichloropyridine-4-carbaldehyde;2,5-DICHLOROPYRIDINE-4-CARBOXALDEHYDE;2,5-dichloro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2,5-dichloro-;2,5-dichloro-3-forMylpyridine-4-carboxylic acid;2,5-DICHLORO-4-FORMYLPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB4771296
- Molecular Formula:
- C6H3Cl2NO
- Molecular Weight:
- 176
- MDL Number:
- MFCD06410679
- MOL File:
- 102645-33-0.mol
- MSDS File:
- SDS
| Melting point | 73-74° |
|---|---|
| Boiling point | 256.3±35.0 °C(Predicted) |
| Density | 1.488±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -3.62±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C6H3Cl2NO/c7-5-2-9-6(8)1-4(5)3-10/h1-3H |
| InChIKey | UIPSRNHDSBVXHY-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(Cl)C(C=O)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
2,5-Dichloro-4-formylpyridine price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D436160-1G | 2,5-Dichloro-4-pyridinecarboxaldehyde | 102645-33-0 | 1g | $205 | 2026-06-03 | Buy |
| Usbiological | 159966 | 2,5-Dichloro-4-pyridinecarboxaldehyde Asreported | 102645-33-0 | 1g | $502 | 2026-06-03 | Buy |
| TRC | TRC-D436160-10G | 2,5-Dichloro-4-pyridinecarboxaldehyde | 102645-33-0 | 10g | $1613 | 2026-06-03 | Buy |
| AstaTech | 52458 | 2,5-DICHLOROISONICOTINALDEHYDE 97% | 102645-33-0 | 1G | $27 | 2026-04-30 | Buy |
| Apolloscientific | OR303891 | 2,5-Dichloroisonicotinaldehyde >98% | 102645-33-0 | 250mg | $21 | 2026-06-04 | Buy |
2,5-Dichloro-4-formylpyridine Chemical Properties,Uses,Production
Uses
2,5-Dichloro-4-pyridinecarboxaldehyde, is an intermediate in the preparation of various pharmaceutical compounds. It is used in the synthesis of 2-Amino-5-aryl-pyridines as selective CB2 agonists.
Synthesis
16110-09-1
68-12-2
102645-33-0
General procedure for the synthesis of 2,5-dichloropyridine-4-carbaldehyde from 2,5-dichloropyridine and N,N-dimethylformamide: First, 2,5-dichloropyridine (27.0 g, 180 mmol) was dissolved in THF (65 mL), which was added via cannulae to a pre-cooled LDA solution at -78°C (100 mL of a 1.8 M solution of 180 mmol, dissolved in THF (80 mL)). After stirring the mixture at -78 °C for 30 min, a solution of DMF (21.1 mL, 271 mmol) in THF (25 mL) was added slowly via syringe. The reaction was kept at -78 °C for 3 h of continued stirring, followed by slow warming to room temperature. The reaction solution was slowly poured into a mixture of ice (800 mL) and hydrochloric acid (150 mL) and stirred for 20 minutes. The pH was adjusted to 9-10 with 3.0 M NaOH solution, followed by extraction with ether (2 x 500 mL). The organic layers were combined, dried and concentrated with MgSO4 to give the crude product as a light yellow solid. This solid was suspended in n-hexane with a small amount of EtOAc and boiled for 5 min before decanting the liquid and evaporating the solvent to give a yellow solid. Finally, purification by Biotage fast chromatography (using a 65i silica gel column loaded with DCM/EtOAc followed by heptane elution with an elution gradient of 20% EtOAc/heptane, 8 column volumes, and then kept at 5 column volumes) afforded the target compound, 2,5-dichloro pyridine-4-carboxaldehyde (17.9 g, 56% yield), as a light yellow solid.1H NMR ( 400 MHz, DMSO-d6) δ 7.85 (s, 1H), 8.76 (s, 1H), 10.22 (s, 1H).
References
[1] Patent: WO2011/27249, 2011, A2. Location in patent: Page/Page column 58
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 132
[4] Patent: WO2005/73232, 2005, A1. Location in patent: Page/Page column 34
2,5-Dichloro-4-formylpyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
View Lastest Price from 2,5-Dichloro-4-formylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2,5-DICHLORO-4-FORMYLPYRIDINE
102645-33-0
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-12-25 | 2,5-DICHLORO-4-FORMYLPYRIDINE
102645-33-0
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 2,5-DICHLORO-4-FORMYLPYRIDINE
102645-33-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,5-DICHLORO-4-FORMYLPYRIDINE
102645-33-0
- $9.80
- ≥99%
- Career Henan Chemical Co
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