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Ethyl N-Boc-piperidine-4-carboxylate

Ethyl N-Boc-piperidine-4-carboxylate structure

CAS No.: 142851-03-4

Chemical Name:: Ethyl N-Boc-piperidine-4-carboxylate

Synonyms: 1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;N-BOC-4-CARBETHOXY PIPERIDINE;1-Boc-isonipecotic acid ethyl ester;Ethyl N-Boc-4-piperidinecarboxylate;Ethyl-N-BOC-4-Piperidine-4-Carboxylate;PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER;calboxylate;BUTTPARK 153\33-50;ETHYL N-BOC-ISONIPECOTATE;1-Boc-piperidine-4-carboxyL

CBNumber:: CB4781820

Molecular Formula:: C13H23NO4

Molecular Weight:: 257.33

MDL Number:: MFCD01763998

MOL File:: 142851-03-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:31:04

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Ethyl N-Boc-piperidine-4-carboxylate Properties

Boiling point	120-135 °C/0.5 mmHg
Density	1.046 g/mL at 25 °C
refractive index	n20/D 1.458
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform, Ethyl Acetate
pka	-2.23±0.40(Predicted)
form	Liquid
color	Clear colorless to pale yellow
InChI	InChI=1S/C13H23NO4/c1-5-17-11(15)10-6-8-14(9-7-10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3
InChIKey	MYHJCTUTPIKNAT-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C(OCC)=O)CC1
CAS DataBase Reference	142851-03-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

22-37/38-41

Safety Statements

26-39

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

Ethyl N-Boc-piperidine-4-carboxylate price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	665150	Ethyl N-Boc-piperidine-4-carboxylate 97%	142851-03-4	5g	$46.3	2026-04-30	Buy
Sigma-Aldrich	665150	Ethyl N-Boc-piperidine-4-carboxylate 97%	142851-03-4	25g	$176	2026-04-30	Buy
TCI Chemical	B2740	Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate >97.0%(GC)	142851-03-4	5g	$22	2026-04-30	Buy
TCI Chemical	B2740	Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate >97.0%(GC)	142851-03-4	25g	$86	2026-04-30	Buy
TRC	TRC-E925260-5G	Ethyl N-Boc-piperidine-4-carboxylate	142851-03-4	5g	$59	2026-06-03	Buy

Product number	Packaging	Price	Buy
665150	5g	$46.3	Buy
665150	25g	$176	Buy
B2740	5g	$22	Buy
B2740	25g	$86	Buy
TRC-E925260-5G	5g	$59	Buy

Ethyl N-Boc-piperidine-4-carboxylate Chemical Properties, Uses, Production

Chemical Properties

Liquid

Uses

Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.

Uses

Substrate used in a palladium-catalyzed α-arylation of esters with heterocyclic bromides and chlorides leading to, for example, 4-pyridylpiperidinyl esters.

Synthesis

24424-99-5

142851-03-4

The general procedure for the synthesis of ethyl N-Boc-4-piperidinecarboxylate from di-tert-butyl dicarbonate was as follows: ethyl isopiperidinate (5.00 g, 0.032 mol) and triethylamine (4.9 mL, 0.035 mol) were dissolved in dichloromethane (25 mL) at 0 °C, and the dichloromethane of di-tert-butyl dicarbonate (7.2 g, 0.033 mol) was slowly added ( 25mL) solution. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, it was washed three times with potassium bisulfate solution and then once with brine. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the target product ethyl N-Boc-4-piperidinecarboxylate (8.23 g, 100% yield) as a colorless oil. The structure of the product was confirmed by 1H NMR (C6D6,500MHz) δ 3.88 (q, J=7.5Hz, 2H), 2.52 (m, 1H), 1.60-1.48 (m, 8H), 1.42 (s, 9H), 0.92 (t, 3H) and mass spectra (280.44 (M+Na)+).

References

[1] Patent: US2004/204397, 2004, A1
[2] Patent: US2003/144302, 2003, A1
[3] Patent: US2002/55631, 2002, A1
[4] Patent: US2002/86887, 2002, A1
[5] Patent: US5716965, 1998, A

Ethyl N-Boc-piperidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl 4-piperidinecarboxylate Di-tert-butyl dicarbonate Dichloromethane Triethylamine

Preparation Products

2-Oxa-8-azaspiro[4.5]decane 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester Ethyl 4-Ethyl-4-piperidinecarboxylate Hydrochloride Ethyl N-Boc-4-(4-fluorobenzyl)piperidine-4-carboxylate

ethyl 4-methanesulfonylpiperidine-4-carboxylate hydrochloride tert-butyl 4-[3-(4-chlorophenyl)-1H-1,2,4-triazol-5-yl]piperidine-1-carboxylate 7-Boc-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nonane tert-butyl 2-benzyl-1-oxo-2,7-diazaspiro[3.5]nonane-7-carboxylate

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Ethyl N-Boc-piperidine-4-carboxylate Suppliers

Global Suppliers ( 334)

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	822	55
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Beijing Ouhe Technology Co., Ltd	60
Shanghai Hobor Chemical Co., Ltd	60
BTC Pharmaceutical CO. Ltd	55
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from Ethyl N-Boc-piperidine-4-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-03	Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4	$10.00	1kg	99%	100tons	Anhui Zhongda Biotechnology Co., Ltd
2023-06-26	Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4	$120.00	10g	99%	500kg/month	Hebei Mingeng Biotechnology Co., Ltd
2023-03-19	Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4		1kg	98% Min	1000kg	LY Global chemicals co.,ltd .

Ethyl N-Boc-piperidine-4-carboxylate
142851-03-4
$10.00
99%
Anhui Zhongda Biotechnology Co., Ltd

Ethyl N-Boc-piperidine-4-carboxylate
142851-03-4
$120.00
99%
Hebei Mingeng Biotechnology Co., Ltd

Ethyl N-Boc-piperidine-4-carboxylate
142851-03-4
98% Min
LY Global chemicals co.,ltd .

Ethyl N-Boc-piperidine-4-carboxylate Spectrum

Ethyl N-Boc-piperidine-4-carboxylate(142851-03-4)¹HNMR Ethyl N-Boc-piperidine-4-carboxylate(142851-03-4)FT-IR

142851-03-4 (Ethyl N-Boc-piperidine-4-carboxylate) Related Search:

Cyhalofop-butyl Ethyl propionate Ethylparaben Buprofezin Cyclohexanecarboxylic acid ethyl ester

Ethyl formate Trinexapac-ethyl Ethyl 4-piperidinecarboxylate Urethane Ethyl cyanoformate

Ethyl nipecotate Ethyl acetate 2-Ethoxyethanol Isonipecotic acid Ethanol

Isoxadifen-ethyl Butyl oleate Oxalic acid

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N-BOC-4-CARBETHOXY PIPERIDINE PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER 1-TERT-BUTYL 4-ETHYL 1,4-PIPERIDINEDICARBOXYLATE 1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE Ethyl N-Boc-piperidine-4-carboxylate N-BOC-4-piperidine forMic acid ethyl ester Ethyl 1-Boc-piperidine-4-carboxylate, 95+% N - bok - 4 - piperidine ethyl forMate Ethyl N-Boc-piperidine-4-calboxylate ETHYL N-BOC-ISONIPECOTATE ETHYL N-BOC-PIPERIDIN-4-YL CARBOXYLATE 1-Tert-butyl-4-ethyl 1,4-piperidie N-Boc-Piperidine-4-carboxylate or ethyl 1-Boc-piperidine-4-carboxylate 1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)piperidine 1-tert-Butyl 4-ethyl piperidine-1,4-dicarboxylate 95+% Ethyl N-boc-piperidine-4-carboxylate Ethyl N-Boc-piperidine-4-carboxylate 97% N-BOC-4-Carbethoxy-4-Piperidone ETHYL N-BOC-PIPERIDINE-4-CARBOXYLATE ETHYL 1-(TERT-BUTYLOXYCARBONYL)ISONIPECOTATE ETHYL 1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINECARBOXYLATE ETHYL 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLATE DIMETHYLETHYL PIPERIDINEDICARBOXYLIC ACID ETHYL ESTER BUTTPARK 153\33-50 1-Boc-4-Carbethoxy Piperidine N-Butoxycarbonyl-4-carbethoxy piperidine Ethyl1-tert-buthoxycarbonylpyridine-4-carboxylate Ethyl N-Boc-4-piperidinecarboxylate 1-(tert-butyl) 4-ethyl tetrahydro-1,4(2H)-pyridinedicarboxylate (en) Ethyl 1-(tert-butoxycarbonyl)-4-piperidinecarboxylate, Ethyl 1-(tert-Butyloxycarbonyl)isonipecotate, Piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester tert-butyl ethyl piperidine-1,4-dicarboxylate 1-Boc-isonipecotic acid ethyl ester, 97+% N-Boc-piperidine-4-carboxylic acid ethyl ester Ethyl piperidine-4-carboxylate, N-BOC protected 95+% 1-tert-butyl ester 4-ethyl ester 1-tert-Butyl 4-ethyl piperidine-1,4-dicarboxylate, 1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)piperidine 1,4-Piperidinedicarboxylic acid, 1-(1,1-diMethylethyl) 4-ethyl ester China manufacturing Ethyl N-Boc-piperidine-4-carboxylate 142851-03-4 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid Ethyl Ester China manufacturing Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate > 1-Boc-piperidine-4-carboxyL N-BOC isonipecotic acid ethyl ester N-Boc-piperidine-4-carboxylate, ethyl ester 1-Boc-4-piperidinecarboxylic Acid Ethyl Ester Ethyl 1-Boc-4-piperidinecarboxylate Piperidine-1,4-dicarboxylic Acid 1-tert-Butyl 4-Ethyl Ester Ethyl N-Boc-piperidine-4-carboxylate USP/EP/BP 1-O-tert-butyl 4-O-ethyl piperidine-1,4-dicarboxylate calboxylate N-Boc-4-piperidinecarboxylic acid ethyl ester 1-Boc-isonipecotic acid ethyl ester 1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Ethyl-N-BOC-4-Piperidine-4-Carboxylate 142851-03-4 Esters Pyrans, Piperidines &Piperazines