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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine structure

CAS No.: 139290-70-3

Chemical Name:: 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

Synonyms: 1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;1-Boc-4-(N-Methoxy-N-MethylcarbaMoyl)piperidine;1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide;N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide;4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected;4-[(MethoxyMethylaMino)carbonyl]-1-piperidinecarboxylic Acid;4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected 98%;ert-Butyl4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid

CBNumber:: CB7296576

Molecular Formula:: C13H24N2O4

Molecular Weight:: 272.34

MDL Number:: MFCD07368262

MOL File:: 139290-70-3.mol

MSDS File:: SDS

Last updated:2026-05-28 02:36:11

Product description	Number	Pack Size	Price
tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate Aldrich	SYX00042	1g	$276
tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate >98.0%(GC)	B3708	1g	$106
N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide	262957	250mg	$286
N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide	262957	500mg	$382
N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide	262957	1g	$493
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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Properties

Melting point	71.0 to 75.0 °C
Boiling point	150°C/0.9mmHg(lit.)
Density	1.106±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form	Oil
pka	-2.31±0.40(Predicted)
color	Pale Yellow
InChI	InChI=1S/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-10(7-9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3
InChIKey	ITCQNWXLNZGEHP-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C(N(OC)C)=O)CC1
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
WGK Germany	WGK 3
HS Code	2933399990
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00042	tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate Aldrich	139290-70-3	1g	$276	2026-04-30	Buy
TCI Chemical	B3708	tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate >98.0%(GC)	139290-70-3	1g	$106	2026-04-30	Buy
Usbiological	262957	N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide	139290-70-3	250mg	$286	2026-06-03	Buy
Usbiological	262957	N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide	139290-70-3	500mg	$382	2026-06-03	Buy
Usbiological	262957	N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide	139290-70-3	1g	$493	2026-06-03	Buy

Product number	Packaging	Price	Buy
SYX00042	1g	$276	Buy
B3708	1g	$106	Buy
262957	250mg	$286	Buy
262957	500mg	$382	Buy
262957	1g	$493	Buy

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Oil

Uses

An intermediate in the production of IKK inhibitors, ERK inhibitors, p38 MAP kinase inhibitors and serotonin receptor antagonists

Synthesis

6638-79-5

84358-13-4

139290-70-3

The general procedure for the preparation of 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine from 1-Boc-4-piperidinecarboxylic acid (2.34 g, 10.2 mmol) and dimethylhydroxylamine hydrochloride (1.5 g, 15 mmol) in DMF (50 mL) was as follows: to a stirred 1-Boc-4-piperidinecarboxylic acid and dimethylhydroxylamine hydrochloride at room temperature in a suspension in DMF was added triethylamine (2.8 mL, 20 mmol). After stirring for 10 min, HOBt (1.62 g, 12 mmol) and EDCI (2.3 g, 12 mmol) were added sequentially. The reaction mixture was stirred overnight and subsequently concentrated. The concentrated residue was dissolved in 1N HCl (100 mL) and extracted with EtOAc (3 × 100 mL). The organic phases were combined, washed sequentially with saturated NaHCO3 solution (50 mL), brine (50 mL), dried over MgSO4 and concentrated to give a colorless oily product (2.79 g, yield >100%). The product was characterized by 1H NMR (500 MHz, CDCl3) and MS (ESI+): 1H NMR δ 4.14 (m, 2H), 3.71 (s, 3H), 3.19 (s, 3H), 2.78 (m, 3H), 1.68 (m, 4H), 1.46 (s, 9H); MS (ESI+) m/z 217.72 (M+H+- Isobutene).

References

[1] Patent: US2004/14763, 2004, A1. Location in patent: Page 21
[2] Patent: WO2008/17461, 2008, A1. Location in patent: Page/Page column 61-62
[3] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 38
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 935 - 939
[5] Patent: WO2006/2434, 2006, A2. Location in patent: Page/Page column 39

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine synthesis

Synthesis of 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine from N,O-Dimethylhydroxylamine hydrochloride and N-BOC-piperidine-4-carboxylic acid

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Preparation Products And Raw materials

Raw materials

1,4-Piperidinedicarboxylic acid N-Boc-Piperidine-4-carboxylic acid methyl ester DI-TERT-BUTYL ETHER Ethyl N-Boc-piperidine-4-carboxylate N-BOC-piperidine-4-carboxylic acid

N,O-Dimethylhydroxylamine hydrochloride N-methoxymethylamine Ethyl 4-piperidinecarboxylate Di-tert-butyl dicarbonate Isonipecotic acid

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Preparation Products

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 1-BOC-PIPERIDIN-4-YLPROPIONIC ACID

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Suppliers

Global( 194)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	931	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2163	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5898	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5742	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Changzhou Ditong Chemical Co.,Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-02	1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 139290-70-3	$1.00	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
139290-70-3
$1.00
98%
Career Henan Chemical Co

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Spectrum

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine(139290-70-3)¹HNMR

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N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE TERT-BUTYL 4-(N-METHOXY-N-METHYLCARBAMOYL)PIPERIDINE-1-CARBOXYLATE 4-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylicacidtert-butylester tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide 1,1-Dimethylethyl 4-[[methyl(methoxy)amino]carbonyl]-1-piperidinecarboxylate tert-Butyl 4-(N-Methoxy-N-MethylcarbaMoyl)-1-piperidinecarboxylate 4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected tert-Butyl 4-[Methoxy(Methyl)-carbaMoyl]piperidin-1-carboxylate 4-[(MethoxyMethylaMino)carbonyl]-1-piperidinecarboxylic Acid 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester 1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide 1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide 1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid 1-Piperidinecarboxylic acid, 4-[(methoxymethylamino)carbonyl]-, 1,1-dimethylethyl ester tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate 1-Boc-4-(N-Methoxy-N-MethylcarbaMoyl)piperidine 4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected 98% tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate > 1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid 1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide 1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester ert-Butyl4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 1,1-Dimethylethyl 4-[(methoxymethylamino)carbonyl]-1-piperidinecarboxylate tert-Butyl 4-[(methoxymethylamino)carbonyl]-1-piperidinecarboxylate 1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE 139290-70-3 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals pharmacetical