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SIRT6-IN-1

SIRT6-IN-1 Structure
SIRT6-IN-1 structure
CAS No.
1214468-35-5
Chemical Name:
SIRT6-IN-1
Synonyms
bdbm50017341;SIRT6IN1,SIRT-6-IN-1,SIRT6 IN 1;1,2,3,4-Tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]-6-quinazolinesulfonamide;2,4-dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide;6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]-
CBNumber:
CB48049588
Molecular Formula:
C19H14N4O5S
Molecular Weight:
410.4
MDL Number:
MFCD11667663
MOL File:
1214468-35-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:39:04
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SIRT6-IN-1 Properties

Density 1.496±0.06 g/cm3(Predicted)
storage temp. -10 to -25°C
solubility DMSO (Slightly)
pka 8.16±0.20(Predicted)
form Solid
color Red to Very Dark Brown
InChI 1S/C19H14N4O5S/c24-18-16-10-15(7-8-17(16)21-19(25)22-18)29(26,27)23-12-3-5-13(6-4-12)28-14-2-1-9-20-11-14/h1-11,23H,(H2,21,22,24,25)
InChIKey CNILPKOOBRBNEQ-UHFFFAOYSA-N
SMILES [S](=O)(=O)(Nc3ccc(cc3)Oc4cnccc4)c1cc2c([nH][c]([nH][c]2=O)=O)cc1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

SIRT6-IN-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PYB46835 SIRT6-IN-1 1214468-35-5 50mg $583 2026-06-04 Buy
Biosynth PYB46835 SIRT6-IN-1 1214468-35-5 0.5g $1817.2 2026-06-04 Buy
ChemScene CS-0081772 SIRT2/6-IN-1 99.79% 1214468-35-5 5mg $54 2026-06-04 Buy
ChemScene CS-0081772 SIRT2/6-IN-1 99.79% 1214468-35-5 10mg $87 2026-06-04 Buy
ChemScene CS-0081772 SIRT2/6-IN-1 99.79% 1214468-35-5 25mg $173 2026-06-04 Buy
Product number Packaging Price Buy
PYB46835 50mg $583 Buy
PYB46835 0.5g $1817.2 Buy
CS-0081772 5mg $54 Buy
CS-0081772 10mg $87 Buy
CS-0081772 25mg $173 Buy

SIRT6-IN-1 Chemical Properties, Uses, Production

Uses

SIRT6-IN-1 is a novel SIRT6 inhibitor, with potential uses in treating in diabetes, immune-mediated disorders, and cancer.

Biological Activity

SIRT6-IN-1 (2,4-dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide) is a cell penetrant, potent and selective inhibitor of SIRT6 (Sirtuin 6). It improves glucose tolerance in a type 2 diabetes mouse model. SIRT6-IN-1 delays experimental autoimmune encephalomyelitis disease onset in mice.

SIRT6-IN-1 synthesis

80650-45-9
56044-12-3
1214468-35-5
Synthesis of SIRT6-IN-1 from 4-(Pyridin-3-yloxy)-phenylamine and 2,4-Dioxo-1,2,3,4-tetrahydro-quinazoline-6-sulfonyl chloride

SIRT6-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

SIRT6-IN-1 Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 sales@linyuepharm.com China 5731 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Bide Pharmatech Ltd. 400-6005915 sales@picasso-e.com China 39662 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 Gsiyu@solarbio.com China 50460 58
LGC Science (Shanghai) Ltd. 17717235263 17717235263 offer.de@lgcgroup.com China 38135 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
TargetMol Chemicals Inc. 58
Bide Pharmatech Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 58
LGC Science (Shanghai) Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from SIRT6-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SIRT6-IN-1 pictures 2026-08-08 SIRT6-IN-1
1214468-35-5
 10g TargetMol Chemicals Inc.

1214468-35-5 (SIRT6-IN-1) Related Search:

SIRT6-IN-1 ARN19874 Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) gamma-Glu-Cys trifluoroacetate salt 5-Carboxy-8-hydroxyquinoline
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1of2

1,2,3,4-Tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]-6-quinazolinesulfonamide 2,4-dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide SIRT6IN1,SIRT-6-IN-1,SIRT6 IN 1 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]- bdbm50017341 1214468-35-5