ARN19874
- CAS No.
- 2190502-57-7
- Chemical Name:
- ARN19874
- Synonyms
- ARN19874;ARN19874 (ARN-19874);1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-6-quinazolinesulfonamide;6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-
- CBNumber:
- CB54814341
- Molecular Formula:
- C19H14N4O4S
- Molecular Weight:
- 394.4
- MDL Number:
- MFCD32201048
- MOL File:
- 2190502-57-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
ARN19874 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24283 | ARN19874 ≥98% | 2190502-57-7 | 500μg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 24283 | ARN19874 ≥98% | 2190502-57-7 | 1mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 24283 | ARN19874 ≥98% | 2190502-57-7 | 5mg | $303 | 2026-04-30 | Buy |
| Cayman Chemical | 24283 | ARN19874 ≥98% | 2190502-57-7 | 10mg | $535 | 2026-04-30 | Buy |
| Biosynth | QMD50257 | ARN19874 | 2190502-57-7 | 10mg | $668.2 | 2026-06-04 | Buy |
ARN19874 Chemical Properties, Uses, Production
Description
ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 μM). It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 μM. ARN19874 (50 μM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide , but not oleoyl ethanolamide or palmitoyl ethanolamide , in HEK293 cells.
Uses
ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM[1].
References
[1] Castellani B, et al. Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817. DOI:10.1039/c7cc07582k
ARN19874 Preparation Products And Raw materials
Raw materials
Preparation Products
ARN19874 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29676 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
