Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3-(3-(Trifluoromethyl)phenyl)propan-1-ol

3-(3-(Trifluoromethyl)phenyl)propan-1-ol

3-(3-(Trifluoromethyl)phenyl)propan-1-ol Structure
3-(3-(Trifluoromethyl)phenyl)propan-1-ol structure
CAS No.
78573-45-2
Chemical Name:
3-(3-(Trifluoromethyl)phenyl)propan-1-ol
Synonyms
3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL;Cinacalcet I;Cinacalcet USP RC E;Sinacase Impurity 48;Cinacalcet InterMediates;Cinacalcet Intermediate 1;CICALCET-ALCOHOL IMPURITY;Cinacalcet Alcohol Impurity;Cinacalcet Related Compound E;Cinacalcet USP Related Compound E
CBNumber:
CB4842637
Molecular Formula:
C10H11F3O
Molecular Weight:
204.19
MDL Number:
MFCD08706408
MOL File:
78573-45-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:52:19
Request For Quotation

3-(3-(Trifluoromethyl)phenyl)propan-1-ol Properties

Boiling point 68-71℃/0.4mm
Density 1.10
refractive index 1.4620 to 1.4660
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 15.04±0.10(Predicted)
form Liquid
color Colorless
InChI InChI=1S/C10H11F3O/c11-10(12,13)9-5-1-3-8(7-9)4-2-6-14/h1,3,5,7,14H,2,4,6H2
InChIKey QWXKQVIMGVVIBX-UHFFFAOYSA-N
SMILES C1(CCCO)=CC=CC(C(F)(F)F)=C1
FDA UNII 64DE6PPY3M

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2906290090
REACH Registrations Active
NFPA 704
1
0 0

3-(3-(Trifluoromethyl)phenyl)propan-1-ol price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3095 3-[3-(Trifluoromethyl)phenyl]-1-propanol >98.0%(GC) 78573-45-2 1g $37 2026-04-30 Buy
TCI Chemical T3095 3-[3-(Trifluoromethyl)phenyl]-1-propanol >98.0%(GC) 78573-45-2 5g $143 2026-04-30 Buy
Biosynth FT35084 3-(3'-Trifluoromethylphenyl)propanol 78573-45-2 50g $324.5 2026-06-04 Buy
Biosynth FT35084 3-(3'-Trifluoromethylphenyl)propanol 78573-45-2 100g $584 2026-06-04 Buy
Biosynth FT35084 3-(3'-Trifluoromethylphenyl)propanol 78573-45-2 250g $780 2026-06-04 Buy
Product number Packaging Price Buy
T3095 1g $37 Buy
T3095 5g $143 Buy
FT35084 50g $324.5 Buy
FT35084 100g $584 Buy
FT35084 250g $780 Buy

3-(3-(Trifluoromethyl)phenyl)propan-1-ol Chemical Properties, Uses, Production

Chemical Properties

Brown Oil

Uses

3-(Trifluoromethyl)benzenepropanol-d4 is an intermediate in the synthesis of Cinacalcet-d4 Hydrochloride (C441803), a labeled analogue of Cinacalcet Hydrochloride (C441800), the (R) enantiomer of Cinacalcet which is used in clinical trial in secondary hyperparathyroidism.

Definition

ChEBI: 3-[3-(trifluoromethyl)phenyl]propan-1-ol is an organofluorine compound that is 3-phenylpropan-1-ol bearing a trifluoromethyl group at position 3 on the phenyl ring. It is an organofluorine compound and a member of propan-1-ols.

Synthesis

3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol

65126-85-4

3-(3-(Trifluoromethyl)phenyl)propan-1-ol

78573-45-2

To a solution of 14.5 g (72.5 mmol) of purified 3-(3-trifluoromethylphenyl)propargyl alcohol in 50 mL of 2-propanol was added 0.38 g of 10% Pd/C (Selcat Q6). The reaction mixture was subjected to hydrogenation at a temperature of 42-45°C and a pressure of 5 bar until all feedstocks were completely converted (about 5 hours). Upon completion of the reaction, it was filtered to remove the catalyst and the catalyst was washed with a small amount of 2-propanol. Subsequently, the filtrate was concentrated by evaporation under reduced pressure. The crude product obtained (14.5 g, 100.0%) was purified by distillation under reduced pressure, resulting in 10.5 g (yield: 72.1%) of the target product 3-(3-trifluoromethylphenyl)propanol as an almost colorless oil (boiling point: 58-60 °C/1.1-1.5 mbar).

References

[1] Organic Letters, 2019, vol. 21, # 1, p. 65 - 69
[2] Patent: US2010/267988, 2010, A1. Location in patent: Page/Page column 4
[3] Patent: EP2327684, 2011, A1. Location in patent: Page/Page column 6
[4] Patent: US2011/124917, 2011, A1. Location in patent: Page/Page column 3

3-(3-(Trifluoromethyl)phenyl)propan-1-ol synthesis

585-50-2
78573-45-2
Synthesis of 3-(3-(Trifluoromethyl)phenyl)propan-1-ol from 3-(3-Trifluoromethylphenyl)propionic acid

3-(3-(Trifluoromethyl)phenyl)propan-1-ol Preparation Products And Raw materials

Raw materials

1-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol 3-(3-Trifluoromethylphenyl)propionic acid 3-(Trifluoromethyl)cinnamic acid 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol 3-(3-Trifluoromethyl-phenyl)-prop-2-en-1-ol
3-（trifluoromethyl) Cinnamaldehyde Cinacalcet Impurity 37 3-(3-(Trifluoromethyl)phenyl)propanal 3-(3-Trifluoromethyl-phenyl)-propionic acid ethyl ester Methyl 3-(3-(trifluoroMethyl)phenyl)propanoate
3-(Trifluoromethyl)benzaldehyde 3-Bromobenzotrifluoride

1of3

Preparation Products

3-(Trifluoromethyl)phenylacetone Benzene, 1-(3-chloropropyl)-3-(trifluoroMethyl)-

3-(3-(Trifluoromethyl)phenyl)propan-1-ol Suppliers

Global Suppliers ( 331)
Supplier Tel Email Country ProdList Advantage
Lu'an Jianuo Biochemical Technology Co., Ltd. 0564-3619988 18056418988;18515382818 549945567@qq.com China 104 58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 13594048950 19923294409 xingcanyaoye@sina.com China 1591 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Changzhou Sunlight Pharmaceutical Co., Ltd 519-83131668 15995063688 info@sunlightchem.com China 100 69
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Lu'an Jianuo Biochemical Technology Co., Ltd. 58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Changzhou Sunlight Pharmaceutical Co., Ltd 69
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Latest Price from 3-(3-(Trifluoromethyl)phenyl)propan-1-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(3'-Trifluoromethylphenyl)propanol pictures 2026-09-11 3-(3'-Trifluoromethylphenyl)propanol
78573-45-2
 1KG 98%min 10000KGS WUHAN FORTUNA CHEMICAL CO., LTD
3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL pictures 2026-08-07 3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL
78573-45-2
 $1.00 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd
3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL pictures 2026-05-28 3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL
78573-45-2
 $5.60 1KG 99% 5000kg Hebei Chuanghai Biotechnology Co,.LTD

3-(3-(Trifluoromethyl)phenyl)propan-1-ol Spectrum

3-(3-(Trifluoromethyl)phenyl)propan-1-ol(78573-45-2)13CNMR3-(3-(Trifluoromethyl)phenyl)propan-1-ol(78573-45-2)IR

78573-45-2 (3-(3-(Trifluoromethyl)phenyl)propan-1-ol) Related Search:

3-(3-(Trifluoromethyl)phenyl)propanal 3-(3-Trifluoromethylphenyl)propionic acid Cinacalcet impurity C N-(1-(naphthalen-1-yl)ethyl)forMaMide cinacalcet iMpurity 4
Methanesulfonic acid 3-(3-trifluoroMethylphenyl)propyl ester Cinacalcet Impurity 46 Cinacalcet IMpurity 3 (1R)-1-(5-methylnaphthalen-1-yl)ethan-1-amine (R)-1-(Naphthalen-2-yl)ethanamine hydrochloride
Cinacalcet IMpurity 7 (E)-m-(trifluoromethyl)cinnamic acid Cinacalcet Impurity 38 HCl Cinacalcet Impurity B Cinacalcet Impurity 45
4-(Trifluoromethyl)hydrocinnamic acid 3-(4-Trifluoromethyl-phenyl)-propan-1-ol 1-Naphthalen-2-yl-ethylamine

1of4

3-(3-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL 3-(Trifluoromethyl)benzenepropanol Cinacalcet Intermediate 1 Cinacalcet I Cinacalcet InterMediates 3-(3-(trifluoroMrthyl)pheny1)propan-1-ol 3-(3-Hydroxyprop-1-yl)benzotrifluoride, 3-(3-Hydroxyprop-1-yl)-alpha,alpha,alpha-trifluorotoluene Benzenepropanol,3-(trifluoroMethyl)- 3-[3-(Trifluoromethyl)phenyl]-1-propanol Cinacalcet USP RC E Cinacalcet USP Related Compound E Cinacalcet Alcohol Impurity Cinacalcet Hydrochloride iMpuritL Cinacalcet Related Compound E CICALCET-ALCOHOL IMPURITY 3-(Trifluoromethyl)cinnamic propional -Trifluoromethyl Phenyl) Propanol 3-(3-Trifluoromethylphenyl)propanol, 3-(3'-Trifluoromethyl Phenyl) Propanol, 3-(3-(Trifluoromethyl)phenyl)-propan-1-ol, 3-(Trifluoromethyl)benzenepropanol, 3-(3-(trifluoromethyl)phenyl)propan-1-ol, 3-(3-Hydroxyprop-1-yl)benzotrifluoride, 3-(3-Hydroxyprop-1-yl)-alpha,alpha,alpha-trifluorotoluene, Cinacalcet Intermediates Sinacase Impurity 48 3-(3-Trifluoromethylphenyl)propanol, 3-(3'-Trifluoromethyl Phenyl) Propanol, 3-(3-(Trifluoromethyl)phenyl)-propan-1-ol, 3-(Trifluoromethyl)benzenepropanol, 3-(3-(trifluoromethyl)phenyl)propan-1-ol, 3-(3-Hydroxyprop-1-yl)benzotrifluoride, 3-(3-Hydroxyprop-1-yl)-alpha,alpha,alpha-trifluorotoluene, Cinacalcet Intermediates 3-(3-(Tri?uoromethyl)phenyl) propan-1-ol 3-(3-Trifluoromethylphenyl)propanol CAS：78573-45-2 3-Trifluoromethylphenylpropyl alcohol 7-(4-Chlorobutoxy)quinolin-2(1H)-one (Intermediate of Brexpiprazole) 3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL 78573-45-2 9553671-05-8 Cinacalcet Intermediate Aromatics Compounds Aromatics Intermediates