3-(3-Trifluoromethylphenyl)propionic acid
- CAS No.
- 585-50-2
- Chemical Name:
- 3-(3-Trifluoromethylphenyl)propionic acid
- Synonyms
- 3-(3-(TRIFLUOROMETHYL)PHENYL)PROPANOIC ACID;Cinacalcet-26;RARECHEM AL BO 1070;Cinacalcet Impurity 39;Cinacalcet Impurity 116;3-Benzotrifluoridepropanoic acid;3-(3-Trifluoromethylphenyl)propionic;3-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID;3-(3-Carboxyprop-1-yl)benzotrifluoride;3-Trifluoromethylbenzenepropanoic acid
- CBNumber:
- CB4743231
- Molecular Formula:
- C10H9F3O2
- Molecular Weight:
- 218.17
- MDL Number:
- MFCD00090487
- MOL File:
- 585-50-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 35°C(lit.) |
|---|---|
| Boiling point | 149°C/11mmHg(lit.) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.56±0.10(Predicted) |
| form | Oil |
| color | Colourless |
| InChI | InChI=1S/C10H9F3O2/c11-10(12,13)8-3-1-2-7(6-8)4-5-9(14)15/h1-3,6H,4-5H2,(H,14,15) |
| InChIKey | YLTJJMIWCCJIHI-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)C(F)(F)F)CCC(=O)O |
| CAS DataBase Reference | 585-50-2(CAS DataBase Reference) |
| FDA UNII | 4U44XHH79H |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
3-(3-Trifluoromethylphenyl)propionic acid price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S766119 | 3-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID AldrichCPR | 585-50-2 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | S766119 | 3-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Aldrich | 585-50-2 | 50mg | $179 | 2024-03-01 | Buy |
| TCI Chemical | T2931 | 3-(3-Trifluoromethylphenyl)propionic Acid >98.0%(GC)(T) | 585-50-2 | 1g | $20 | 2026-04-30 | Buy |
| TCI Chemical | T2931 | 3-(3-Trifluoromethylphenyl)propionic Acid >98.0%(GC)(T) | 585-50-2 | 5g | $48 | 2026-04-30 | Buy |
| Usbiological | 290714 | 3-(3-Trifluoromethylphenyl)propionic acid Asreported | 585-50-2 | 5g | $337 | 2026-06-03 | Buy |
3-(3-Trifluoromethylphenyl)propionic acid Chemical Properties,Uses,Production
Description
3-(3-Trifluoromethylphenyl)propionic acid is an important organic solvent with a mild, pleasant aroma, used as an efficient organic reagent in polymer production processes and as a co-catalyst for trifluoroacetic acid. It is used in biological research as a substrate for the synthesis of various compounds and for the study of enzyme-catalysed reactions. It is also used in the synthesis of cinacalcet. Cinacalcet is a drug used to treat chronic kidney disease (dialysis) and high levels of calcium in the blood (parathyroid disease).
Chemical Properties
3-(3-Trifluoromethylphenyl)propionic acid has the appearance of a white or colourless to yellowish powder to a lumpy to clear liquid with a melting point of 35 °C and a boiling point of 149 °C/11 mmHg; store at room temperature.
Uses
3-(3-Trifluoromethylphenyl)propionic Acid can be used as catalysts.
Uses
3-(3-Trifluoromethylphenyl)propionic acid is used in the synthesis of Cinacalcet and also participates in the boron-catalyzed N-alkylation of amines of carboxylic acids.
Preparation
3-(3-Trifluoromethylphenyl)propionic acid is synthesised by the reaction of 3-trifluoromethylaniline and propionic acid.
Synthesis
779-89-5
585-50-2
Preparation of 3-(3-trifluoromethylphenyl)propionic acid: 3-Trifluoromethylcinnamic acid (0.463 mol, 100 g) was dissolved in 1.0 L of methanol and transferred to a hydrogenation reactor. 5% Pd/C catalyst (3 g) was added. The hydrogenation reaction was carried out at 1 kg/cm2 Hpressure and 250 °C for about 10 hours. Upon completion of the reaction, the reaction mixture was filtered and the catalyst was washed with methanol (100 mL). The filtrate was distilled under reduced pressure to remove the methanol to give 3-(3-trifluoromethylphenyl)propionic acid as crude product (100 g, 100% yield).
References
[1] Patent: WO2010/100429, 2010, A1. Location in patent: Page/Page column 19
[2] Patent: WO2008/117299, 2008, A1. Location in patent: Page/Page column 16
[3] Beilstein Journal of Organic Chemistry, 2012, vol. 8, p. 1366 - 1373
[4] Patent: US2009/99228, 2009, A1. Location in patent: Page/Page column 10-11; 18
[5] Patent: EP2013209, 2011, B1. Location in patent: Page/Page column 22
3-(3-Trifluoromethylphenyl)propionic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lu'an Jianuo Biochemical Technology Co., Ltd. | 0564-3619988 18056418988;18515382818 | 549945567@qq.com | China | 104 | 58 |
| Wuhan woxuan Technology Co., Ltd | 13322067656 | 3199863540@qq.com | China | 3905 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Changzhou Sunlight Pharmaceutical Co., Ltd | 519-83131668 15995063688 | info@sunlightchem.com | China | 100 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Lastest Price from 3-(3-Trifluoromethylphenyl)propionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | 3-(3-Trifluoromethylphenyl)propionic acid
585-50-2
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 3-(3-Trifluoromethylphenyl)propionic acid
585-50-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-10-31 | 3-(3-Trifluoromethylphenyl)propionicacid
585-50-2
|
10g | 98% | 10tons | Yangzhou Qinyuan Pharmatech Co.,ltd |
-
- 3-(3-Trifluoromethylphenyl)propionic acid
585-50-2
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-(3-Trifluoromethylphenyl)propionic acid
585-50-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-(3-Trifluoromethylphenyl)propionicacid
585-50-2
- $0.00
- 98%
- Yangzhou Qinyuan Pharmatech Co.,ltd
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