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Thiophene-2-ethylamine

CAS No.
30433-91-1
Chemical Name:
Thiophene-2-ethylamine
Synonyms
2-(thiophen-2-yl)ethan-1-aMine;2-THIOPHENEETHYLAMINE;2-(2-AMINOETHYL)THIOPHENE;2-Thien-2-yL;ThiopheneEthaMine;RARECHEM AL BW 0099;2-Thiopheneethamine;2-Thiopheneethylamin;2-ThiophenethylaMine;THIOPHENE ETHYLAMINE
CBNumber:
CB4853460
Molecular Formula:
C6H9NS
Molecular Weight:
127.21
MDL Number:
MFCD06090846
MOL File:
30433-91-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:16:12
Product description Number Pack Size Price
2-Thiopheneethylamine 96% 423270 1g $32.9
2-Thiopheneethylamine 96% 423270 5g $163
2-(2-Aminoethyl)thiophene >98.0%(GC) A1637 25g $84
2-(2-Aminoethyl)thiophene >98.0%(GC) A1637 250g $528
2-(2-Aminoethyl)thiophene ≥98%(GC) 44179 5G $20.43
More product size

Thiophene-2-ethylamine Properties

Melting point 202 °C
Boiling point 200-201 °C/750 mmHg (lit.)
Density 1.087 g/mL at 25 °C (lit.)
refractive index n20/D 1.551(lit.)
Flash point 190 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO, Methanol
pka 9.47±0.10(Predicted)
form Liquid
Specific Gravity 1.087
color Colorless to yellow
Sensitive Air Sensitive
BRN 106962
InChI 1S/C6H9NS/c7-4-3-6-2-1-5-8-6/h1-2,5H,3-4,7H2
InChIKey HVLUYXIJZLDNIS-UHFFFAOYSA-N
SMILES NCCc1cccs1
CAS DataBase Reference 30433-91-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-37/39
RIDADR  NA 1993 / PGIII
WGK Germany  3
HazardClass  IRRITANT
HazardClass  8
PackingGroup  II
HS Code  29339900
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
3 0

Thiophene-2-ethylamine price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 423270 2-Thiopheneethylamine 96% 30433-91-1 1g $32.9 2026-04-30 Buy
Sigma-Aldrich 423270 2-Thiopheneethylamine 96% 30433-91-1 5g $163 2026-04-30 Buy
TCI Chemical A1637 2-(2-Aminoethyl)thiophene >98.0%(GC) 30433-91-1 25g $84 2026-04-30 Buy
TCI Chemical A1637 2-(2-Aminoethyl)thiophene >98.0%(GC) 30433-91-1 250g $528 2026-04-30 Buy
Chem-Impex 44179 2-(2-Aminoethyl)thiophene ≥98%(GC) 30433-91-1 5G $20.43 2026-05-19 Buy
Product number Packaging Price Buy
423270 1g $32.9 Buy
423270 5g $163 Buy
A1637 25g $84 Buy
A1637 250g $528 Buy
44179 5G $20.43 Buy

Thiophene-2-ethylamine Chemical Properties,Uses,Production

Chemical Properties

A colorless to yellow liquid with unstable properties requiring protection with nitrogen gas. It appears as a light yellow clear liquid, but turns red upon prolonged exposure.

Uses

[2-(Thiophene-2-yl)ethyl]amine is used in the synthesis of geldanamycin derivatives as HCV replication inhibitors targetting Hsp90.

Uses

2-Thiopheneethylamine (2-thiophene ethyl amine, 2-(thien-2-yl)ethylamine) is suitable to functionalize multiwall carbon nanotubes (MWCNT).
It may be used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones and acylguanidines derivatives by reacting with aroyl S-methylisothiourea.

General Description

2-Thiopheneethylamine (2-(thiophen-2-yl)ethanamine) is an aromatic amine. It undergoes microwave induced condensation with iminodiacetic acid to form the corresponding piperazine-2,6-dione derivatives. Its effect as a probable substitute to the pyridine ligand on the performance of poly(3-hexylthiophene)/CdSe hybrid solar cells has been investigated.

Synthesis

N,N-Dimethylformamide (DMF) reacts with thiophene to obtain 2-thiophenecarbaldehyde, then reacts with isopropyl chloroacetate to obtain 2-thiopheneacetaldehyde, and then reacts with hydroxylamine hydrochloride to obtain 2-thiopheneacetaldehyde oxime, and finally reduced to give 2-thiopheneethylamine.

References

[1] M. BARWIOLEK. Structural and spectral studies of silver(I) complexes with new Schiff bases derived from 2-thiopheneethylamine and their application in thin layer deposition by spin and dip coating techniques[J]. Polyhedron, 2017, 124: Pages 12-21. DOI:10.1016/j.poly.2016.12.011.
[2] BHUSHAN D. VARPE S B J. Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity[J]. Russian Journal of Bioorganic Chemistry, 2022, 48 2: 372-379. DOI:10.1134/S1068162022020030.
[3] JUN YAN LEK. Understanding the Effect of Surface Chemistry on Charge Generation and Transport in Poly (3-hexylthiophene)/CdSe Hybrid Solar Cells[J]. ACS Applied Materials & Interfaces, 2011, 3 2: 287-292. DOI:10.1021/am100938f.
[4] SANDEEP KUMAR. Efficient synthesis of piperazine-2,6-dione and 4-(1H-indole-2-carbonyl)piperazine-2,6-dione derivatives and their evaluation for anticancer activity[J]. Medicinal Chemistry Research, 2013, 22 10: 4600-4609. DOI:10.1007/s00044-012-0438-7.

30807-46-6
30433-91-1
Synthesis of Thiophene-2-ethylamine from Thiophene, 2-(2-nitroethyl)-
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View Lastest Price from Thiophene-2-ethylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thiophene-2-ethylamine pictures 2026-01-04 Thiophene-2-ethylamine
30433-91-1
US $0.00-0.00 / KG 1KG 98 10000KGS Shaanxi Dideu New Materials Co. Ltd
Thiophene-2-ethylamine  pictures 2025-11-18 Thiophene-2-ethylamine
30433-91-1
US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
2-Thiopheneethylamine pictures 2025-06-20 2-Thiopheneethylamine
30433-91-1
US $0.00 / kg 1kg 99% 20tons Hebei Yanxi Chemical Co., Ltd.
20(2-thienyl)ethylamine 2-(2'-Thienyl) ethyl amine/ Thiophene-2-ethylamine 2-(2-Aminoethyl)thiophene~Thiophene-2-ethylamine 2-Thiopheneethylamin Thiophene-2-Ethylamine ,99% 2-(2-Thienyl)ethanamine 2-Thiopheneethanamine Thiophene-2-ethanamine Thiophene-2-ethylamine,98% 2-Thiophen-2-ylethanamine 2-(2-thienyl)ethanamine(SALTDATA: FREE) 2-ThiophenethylaMine 2-(Thien-2-yl)ethylamine 2-(thiophen-2-yl)ethan-1-aMine ThiopheneEthaMine [2-(Thiophene-2-yl)ethyl]aMine THIOPHENE ETHYLAMINE THIOPHENE-2-ETHYLAMINE THIOPHENE-2-ETHYLAMINE HCL SALT RARECHEM AL BW 0099 2-(2-AMINOETHYL)THIOPHENE 2-(2'-THIENYL)ETHYL AMINE 2-(2-THIENYL)ETHYLAMINE 2-(2-THIENYL)-1-ETHANAMINE 2-(2-THIENYL)-1-ETHANAMINE HYDROCHLORIDE 2-AMINOETHYLTHIOPHENE 2-THIOPHENEETHYLAMINE B-2-THIENYLETHYLAMINE .beta.-2-Thienylethylamine Thiophen-2-ylacetyl chloride 2-Thiopheneethamine 2-(2-Aminoethyl)thiophene > 2-Thien-2-yL Thiophene-2-ethylamine ISO 9001:2015 REACH 2-(Thiophen-2-yl)ethylamine Rotigotine Impurity 17 2-Thiopheneethylamine, 96% 30433-91-1 423-27-0 30433-14-3 8349-17-0 C6H9SN AMINE Building Blocks Heterocyclic Building Blocks Thiophenes Building Blocks C4 to C6 Chemical Synthesis Heterocyclic Building Blocks Building Blocks Heterocyclic Building Blocks Thiophenes Amines Heterocyclic Compounds Ticlopidine Clopidogrel Anilines, Aromatic Amines and Nitro Compounds Thiophene&Benzothiophene