4-Aminobenzamidine dihydrochloride
- CAS No.
- 2498-50-2
- Chemical Name:
- 4-Aminobenzamidine dihydrochloride
- Synonyms
- P-AMINOBENZAMIDINE DIHYDROCHLORIDE;P-AMINOBENZAMIDINE DIHCL;4-AMINOBENZAMIDINE HCL SALT;SC-67235;4-Aminobenzamidine HCl;4-Aminobenzamidine2HCl;Dabigatran Impurity 89;π-Aminobenzamidine 2HCl;4-Aminobenzamidine DiHCl;4-Aminobenzimidamide 2HCl
- CBNumber:
- CB4377267
- Molecular Formula:
- C7H11Cl2N3
- Molecular Weight:
- 208.09
- MDL Number:
- MFCD00013001
- MOL File:
- 2498-50-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Aminobenzamidine dihydrochloride BioReagent, suitable for fluorescence, ≥99.0% (TLC) | 06880 | 5g | $234 |
| 4-Aminobenzamidine dihydrochloride BioReagent, suitable for fluorescence, ≥99.0% (TLC) | 06880 | 1g | $49.4 |
| 4-Aminobenzamidine Dihydrochloride >98.0%(N) | A2115 | 5g | $114 |
| 4-Aminobenzamidine Dihydrochloride >98.0%(N) | A2115 | 25g | $426 |
| 4-Aminobenzamidine Dihydrochloride | TRC-A587200-25G | 25g | $696 |
| More product size | |||
| Melting point | >300 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Water |
| form | Fine Crystalline Powder |
| color | White to yellow |
| Sensitive | Hygroscopic |
| BRN | 3692927 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H |
| InChIKey | GHEHNICLPWTXJC-UHFFFAOYSA-N |
| SMILES | C1(C=CC(N)=CC=1)C(=N)N.Cl.Cl |
| CAS DataBase Reference | 2498-50-2(CAS DataBase Reference) |
| FDA UNII | 3C7VNU62AG |
| UNSPSC Code | 12352100 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CV6126500 | |||||||||
| F | 3-10-21 | |||||||||
| HS Code | 29252900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Aminobenzamidine dihydrochloride price More Price(97)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 06880 | 4-Aminobenzamidine dihydrochloride BioReagent, suitable for fluorescence, ≥99.0% (TLC) | 2498-50-2 | 5g | $234 | 2026-04-30 | Buy |
| Sigma-Aldrich | 06880 | 4-Aminobenzamidine dihydrochloride BioReagent, suitable for fluorescence, ≥99.0% (TLC) | 2498-50-2 | 1g | $49.4 | 2022-05-15 | Buy |
| TCI Chemical | A2115 | 4-Aminobenzamidine Dihydrochloride >98.0%(N) | 2498-50-2 | 5g | $114 | 2026-04-30 | Buy |
| TCI Chemical | A2115 | 4-Aminobenzamidine Dihydrochloride >98.0%(N) | 2498-50-2 | 25g | $426 | 2026-04-30 | Buy |
| TRC | TRC-A587200-25G | 4-Aminobenzamidine Dihydrochloride | 2498-50-2 | 25g | $696 | 2026-06-03 | Buy |
4-Aminobenzamidine dihydrochloride Chemical Properties,Uses,Production
Chemical Properties
white to yellowish fine crystalline powder
Uses
4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is used as a ligand in affinity chromatography for purification and immobilization of enzymes.
Application
4-Aminobenzamidine dihydrochloride can be used to synthesize:
Orally active fibrinogen receptor antagonists based on benzamidines.
Benzamidine derivatives that are selective and potent serine protease inhibitors.
Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.
Synthesis of a selective inhibitor of PRMT1 (SKLB-639)
Preparation
4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.
Definition
ChEBI: P-Aminobenzamidine dihydrochloride is an organic molecular entity.
Synthesis
25412-75-3
2498-50-2
In a three-necked flask equipped with a reflux condenser tube and a mechanical stirring device, 15.0 g of 4-nitrobenzenecarboximidamide (IV) prepared from Example 2, 20 mL of acetic acid, 45 mL of water, and 45 mL of ethanol (V water: V ethanol=1:1) were added, and the reaction was stirred and refluxed at 60° C. until complete dissolution. Subsequently, 20.3 g of iron powder (n4-nitrobenzenecarboximidamide IV: n iron powder = 1:4) was added to the reaction system, and the reaction was warmed up to 80 °C and continued to be stirred and refluxed for 4 hours. After completion of the reaction, it was filtered while hot. The filtrate was adjusted to pH 11~12 with 20% NaOH solution, at which time a large amount of flocculent precipitation was generated, and after filtration, the filtrate was adjusted to pH 1~2 with concentrated hydrochloric acid. the solution was concentrated until the crystals precipitated, and the resulting crystals were dried in vacuum at 100 ℃ to obtain 17.9 g of 4-nitrobenzenecarboximidamide dihydrochloride (I), as a white solid with 94.7% yield and 99.51% HPLC purity.
References
[1] Patent: CN104163778, 2016, B. Location in patent: Paragraph 0056; 0057
4-Aminobenzamidine dihydrochloride Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5994 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5224 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 | sales@suikangpharm.com | China | 311 | 58 |
| Anhuyan (Hainan) Biotechnology Co., LTD | +8618163349544 | mollylucking@foxmail.com | China | 3000 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 670 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
View Lastest Price from 4-Aminobenzamidine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-13 | 4-aminobenzenecarboximidamide,dihydrochloride
2498-50-2
|
$1.00 | 10000000g | 99.9% | 5000 | .GZ HONESTCHEM CO.,LTD | |
 |
2026-07-13 | 4-aminobenzenecarboximidamide,dihydrochloride
2498-50-2
|
$1.00 | 10g | 99.99% | 20tons | .GZ HONESTCHEM CO.,LTD | |
 |
2026-07-13 | 4-Aminobenzamidine dihydrochloride
2498-50-2
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 4-aminobenzenecarboximidamide,dihydrochloride
2498-50-2
- $1.00
- 99.9%
- .GZ HONESTCHEM CO.,LTD
-
- 4-aminobenzenecarboximidamide,dihydrochloride
2498-50-2
- $1.00
- 99.99%
- .GZ HONESTCHEM CO.,LTD
-
- 4-Aminobenzamidine dihydrochloride
2498-50-2
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
