2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)-
- CAS No.
- 214287-90-8
- Chemical Name:
- 2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)-
- Synonyms
- DMP963;DMP-963;DMP 963;2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)-
- CBNumber:
- CB48924977
- Molecular Formula:
- C14H9F5N2O
- Molecular Weight:
- 316.23
- MDL Number:
- MOL File:
- 214287-90-8.mol
- MSDS File:
- SDS
2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)- Properties
| Melting point | 187 °C |
|---|---|
| Boiling point | 340.3±42.0 °C(Predicted) |
| Density | 1.54±0.1 g/cm3(Predicted) |
| pka | 7.84±0.40(Predicted) |
| FDA UNII | XEW2AAG1IS |
2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)- Chemical Properties, Uses, Production
Uses
DPC-963 is an oral active non-nucleoside reverse transcriptase inhibitor with the IC50 of 18 nM. DPC-963 can be used for study of HIV[1][2].
References
[1] Corbett JW, et al. Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1999;43(12):2893-2897. DOI:10.1128/AAC.43.12.2893
[2] Corbett JW, et al. Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors. J Med Chem. 2000;43(10):2019-2030. DOI:10.1021/jm990580e
2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)- Preparation Products And Raw materials
Raw materials
Preparation Products
2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
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