Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-
![Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Structure](CAS/20210305/GIF/2569009-58-9.gif)
- CAS No.
- 2569009-58-9
- Chemical Name:
- Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-
- Synonyms
- CTX-3648;PF-9363 (CTx-648);PF-9363, 10 mM in DMSO;2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1 -ylmethyl)-1,2-benzoxazol-3-yl]benzenesulfonamide;2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-benzenesulfonamide;N-(6-((1H-Pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-yl)-2,6-dimethoxybenzenesulfonamide;Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-;CTx-648,cancer,patient-derived,anti-tumor,HAT,CTx648,Inhibitor,HATs,selective,xenograft,CTx 648,Histone Acetyltransferase,PF9363,inhibit,PF 9363,potent,PF-9363
- CBNumber:
- CB49014266
- Molecular Formula:
- C20H20N4O6S
- Molecular Weight:
- 444.46
- MDL Number:
- MFCD34474252
- MOL File:
- 2569009-58-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Properties
| Boiling point | 692.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 2mg/mL, clear (Warmed) |
| form | Solid |
| pka | 6.34±0.30(Predicted) |
| color | White to off-white |
| InChI | 1S/C20H20N4O6S/c1-27-14-6-4-7-15(28-2)19(14)31(25,26)23-20-18-16(29-3)10-13(11-17(18)30-22-20)12-24-9-5-8-21-24/h4-11H,12H2,1-3H3,(H,22,23) |
| InChIKey | VNSQFPFWUAZOTQ-UHFFFAOYSA-N |
| SMILES | O=S(NC1=NOC2=CC(CN3N=CC=C3)=CC(OC)=C21)(C4=C(OC)C=CC=C4OC)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37778 | PF-9363 ≥98% | 2569009-58-9 | 1mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 37778 | PF-9363 ≥98% | 2569009-58-9 | 5mg | $198 | 2026-04-30 | Buy |
| Cayman Chemical | 37778 | PF-9363 ≥98% | 2569009-58-9 | 10mg | $351 | 2026-04-30 | Buy |
| Cayman Chemical | 37778 | PF-9363 ≥98% | 2569009-58-9 | 25mg | $767 | 2026-04-30 | Buy |
| Biosynth | UCE00958 | PF-9363 | 2569009-58-9 | 10mg | $171.9 | 2026-06-05 | Buy |
Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Chemical Properties, Uses, Production
Uses
PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2].
Biological Activity
PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2]. PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1].PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1]. PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].
in vivo
PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].
IC 50
MOZ/MORF
References
[1]. Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation [2]. WO2020254946
Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
| Fujian boshi pharmaceutical technology co. LTD | 0595-22008920; 18120708884 | 393612455@qq.com | China | 257 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9733 | 58 |
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Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Spectrum
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