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2,6-Difluoro-4-nitrophenol

2,6-Difluoro-4-nitrophenol Structure
2,6-Difluoro-4-nitrophenol structure
CAS No.
658-07-1
Chemical Name:
2,6-Difluoro-4-nitrophenol
Synonyms
4-nitro-2,6-Difluorophenol;2,6-Difluoro-4-nitrophenol;Phenol, 2,6-difluoro-4-nitro-;2,6-Difluoro-4-nitrophenol 98%;2,6-Difluoro-4-nitrophenol，GC，97%;3,5-Difluoro-4-hydroxynitrobenzene
CBNumber:
CB4969909
Molecular Formula:
C6H3F2NO3
Molecular Weight:
175.09
MDL Number:
MFCD07366521
MOL File:
658-07-1.mol
MSDS File:
SDS
Last updated:2026-05-28 02:08:16
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2,6-Difluoro-4-nitrophenol Properties

Melting point 99.7-100.7°C
Boiling point 254.5±40.0 °C(Predicted)
Density 1.619±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
form crystalline powder
pka 4.28±0.44(Predicted)
color Faint yellow
InChI InChI=1S/C6H3F2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H
InChIKey KVVXRISUSPIMLJ-UHFFFAOYSA-N
SMILES C1(O)=C(F)C=C([N+]([O-])=O)C=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P280-P312
Hazard Codes  Xi
HS Code  2908990000

2,6-Difluoro-4-nitrophenol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC9845 2,6-Difluoro-4-nitrophenol 98% 658-07-1 1g $30 2026-06-04 Buy
Apolloscientific PC9845 2,6-Difluoro-4-nitrophenol 98% 658-07-1 5g $112 2026-06-04 Buy
Apolloscientific PC9845 2,6-Difluoro-4-nitrophenol 98% 658-07-1 25g $516 2026-06-04 Buy
Activate Scientific AS30796 2,6-Difluoro-4-nitrophenol 98% 658-07-1 1g $39 2026-06-04 Buy
Activate Scientific AS30796 2,6-Difluoro-4-nitrophenol 98% 658-07-1 5g $139 2026-06-04 Buy
Product number Packaging Price Buy
PC9845 1g $30 Buy
PC9845 5g $112 Buy
PC9845 25g $516 Buy
AS30796 1g $39 Buy
AS30796 5g $139 Buy

2,6-Difluoro-4-nitrophenol Chemical Properties, Uses, Production

Chemical Properties

Light yellow crystalline

Synthesis

2,6-Difluorophenol

28177-48-2

Ethyl acetate

141-78-6

2,6-Difluoro-4-nitrophenol

658-07-1

The general procedure for the synthesis of 2,6-difluoro-4-nitrophenol from 2,6-difluorophenol and ethyl acetate is as follows: with reference to Example 103, 2,6-difluorophenol (2.00 g) was dissolved in acetic acid (20 ml), and 60% nitric acid (1.20 ml) was slowly added dropwise under ice bath conditions. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with saturated saline and the organic layer was dried with anhydrous magnesium sulfate. The dried organic layer was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent being a mixed solvent with the volume ratio of hexane/ethyl acetate=3/1→2/1, resulting in the target compound 2,6-difluoro-4-nitrophenol (1.37 g, 51% yield) as a light yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3), δppm: 7.95 (2H, m).

References

[1] Patent: US6555556, 2003, B1

2,6-Difluoro-4-nitrophenol synthesis

28177-48-2
141-78-6
658-07-1
Synthesis of 2,6-Difluoro-4-nitrophenol from 2,6-Difluorophenol and Ethyl acetate

2,6-Difluoro-4-nitrophenol Preparation Products And Raw materials

Raw materials

3,4,5-Trifluoronitrobenzene 2,6-Difluorophenol Hexane Acetic acid Ethyl acetate
Nitric acid 2,6-Difluoroaniline 2,6-Difluorobenzamide

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Preparation Products

2-Fluoro-4-nitrophenol 4-Amino-2,6-difluorophenol

2,6-Difluoro-4-nitrophenol Suppliers

Global Suppliers ( 114)
Supplier Tel Email Country ProdList Advantage
Shanghai Titan Enterprise Development Co., Ltd 16621224781 syy@titansci.com China 2893 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Heterochem 027-88041443 13072715837 sales@hetero-chem.com China 695 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Supplier Advantage
Shanghai Titan Enterprise Development Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shanghai Sphchem Co., Ltd. 55
Heterochem 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55

View Latest Price from 2,6-Difluoro-4-nitrophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-Difluoro-4-nitrophenol pictures 2026-08-25 2,6-Difluoro-4-nitrophenol
658-07-1
 $22.00-88.00 1kg 99% 50kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2,6-Difluoro-4-nitrophenol pictures 2019-12-26 2,6-Difluoro-4-nitrophenol
658-07-1
 $2.00 1KG 98%MIN Career Henan Chemical Co

2,6-Difluoro-4-nitrophenol Spectrum

2,6-Difluoro-4-nitrophenol(658-07-1)1HNMR2,6-Difluoro-4-nitrophenol(658-07-1)19FNMR

658-07-1 (2,6-Difluoro-4-nitrophenol) Related Search:

Titanous chloride 2,4,5-Trifluoro-3-methoxy-6-nitrobenzoic acid 2,6-Difluoro-4-nitroanisole 2,6-Difluorophenol 4-Amino-2,6-difluorophenol
2,6-Difluoro-4-nitrophenol

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2,6-Difluoro-4-nitrophenol 2,6-Difluoro-4-nitrophenol 98% 3,5-Difluoro-4-hydroxynitrobenzene 4-nitro-2,6-Difluorophenol Phenol, 2,6-difluoro-4-nitro- 2,6-Difluoro-4-nitrophenol，GC，97% 658-07-1