ChemicalBook >> CAS DataBase List >>2,6-Difluoroaniline
2,6-Difluoroaniline
- CAS No.
- 5509-65-9
- Chemical Name:
- 2,6-Difluoroaniline
- Synonyms
- 2,6-DIFLUOROBENZENAMINE;2,6-Difuluoroaniline;2,6-DifluorophenylaMine;2,6-DifluorobenzeneaMine;26DFA;NSC 127234;JACS-5509-65-9;6-Difluoroaniline;Abesili Impurity 8;2,6-DIFLUOROANILINE
- CBNumber:
- CB5478710
- Molecular Formula:
- C6H5F2N
- Molecular Weight:
- 129.11
- MDL Number:
- MFCD00007655
- MOL File:
- 5509-65-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 02:43:18
| Boiling point | 51-52 °C/15 mmHg (lit.) |
|---|---|
| Density | 1.199 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 110 °F |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 1.81±0.10(Predicted) |
| Specific Gravity | 1.28 |
| color | Clear yellow to brown |
| Water Solubility | Slightly soluble in water. |
| BRN | 2802697 |
| Stability | Hygroscopic |
| InChI | 1S/C6H5F2N/c7-4-2-1-3-5(8)6(4)9/h1-3H,9H2 |
| InChIKey | ODUZJBKKYBQIBX-UHFFFAOYSA-N |
| SMILES | Nc1c(F)cccc1F |
| CAS DataBase Reference | 5509-65-9(CAS DataBase Reference) |
| FDA UNII | 943G3H8895 |
| NIST Chemistry Reference | 2,6-Difluoroaniline(5509-65-9) |
| EPA Substance Registry System | 2,6-Difluoroaniline (5509-65-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302+H312+H332-H317 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P304+P340+P312 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi,F | |||||||||
| Risk Statements | 10-20/21/22-36/37/38 | |||||||||
| Safety Statements | 36-36/37/39-26-23-16-16/23/26/36/37/39-24/25 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-23 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214210 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Flam. Liq. 3 Skin Sens. 1 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,6-Difluoroaniline price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 196614 | 2,6-Difluoroaniline ≥97% | 5509-65-9 | 5g | $59.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 196614 | 2,6-Difluoroaniline ≥97% | 5509-65-9 | 25g | $79.1 | 2026-04-30 | Buy |
| TCI Chemical | D1635 | 2,6-Difluoroaniline >98.0%(GC) | 5509-65-9 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | D1635 | 2,6-Difluoroaniline >98.0%(GC) | 5509-65-9 | 25g | $66 | 2026-04-30 | Buy |
| TRC | TRC-D445530-5G | 2,6-Difluoroaniline | 5509-65-9 | 5g | $77 | 2026-06-03 | Buy |
2,6-Difluoroaniline Chemical Properties, Uses, Production
Chemical Properties
clear yellow to brown liquid
Uses
2,6-Difluoroaniline is an important chemical in the sythesis technology for high-efficiency insecticide.
Uses
2,6-Difluoroaniline was used in the synthesis of:
- N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, herbicidal compound
- series of 2,6,9-trisubstituted purine inhibitors of p38α kinase
- substituted phenylthiomorpholine dioxide, an active pharmaceutical intermediate
Uses
2,6-Difluoroaniline and several related primary amines are oxidized in chloroform by peroxybenzoic acid to the corresponding nitroso compounds. For example, treatment of 2,6-difluoroaniline with sodium azide can obtain 4-fluoro-2,1,3-benzoxadiazole, and the product is nitrified to obtain 7-nitro derivatives[1]. 2,6-Difluoroaniline is an important raw material and intermediate in organic synthesis, medicine, pesticides, dyes and other fields.
Toxics Screening Level
The initial threshold screening level (ITSL) for 2,6-difluoroaniline (DFA) is 2.0 μg/m3 based on an annual averaging time.
References
[1] Nunno L, et al. Oxidation of substituted anilines to nitroso-compounds. J. Chem. Soc. C, 1970; 9: 1433-1434.
2,6-Difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
DBD-PZ
Abemaciclib
N1-(2,6-Difluoro-3-nitrophenyl)acetamide
4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
4-Bromo-2,6-difluoroaniline
4-Amino-2,6-difluorophenol
2,6-Difluoro-4-nitrophenol
2,6-Difluoro-4-nitroaniline
4-Fluoro-2,1,3-benzoxadiazole
1of4
Global Suppliers ( 605)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tai 'an Huanyu Chemical Co., LTD | 13176825516; 13176825516 | 78995114@qq.com | China | 79 | 58 |
| Shanghai QianJin Chemical Technology Co., Ltd | 021-20900665 17321230821 | 2986274987@qq.com | China | 754 | 55 |
| Weifang QianJin Fine Chemical Co., Ltd. | 18753684562 | 1577399715@qq.COM | China | 1773 | 55 |
| Qufu Delu Biotechnology Co., Ltd | 13562421518 | deluxe11@163.com | China | 61 | 58 |
| Shandong Lifan Chemical Co. LTD | 17661223836 | 896889070@qq.com | China | 97 | 58 |
| Zhejiang Xieshi New Materials Co., Ltd., | 17858121723 | sales09@xieshichem.com | China | 191 | 58 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 2,6-Difluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 2,6-Difluoroaniline
5509-65-9
|
1000KG | 99 | 20000 | Gansu Jinyuantai New Material Co., Ltd. | ||
 |
2026-09-02 | 2,6-Difluoroaniline
5509-65-9
|
$3.00-10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2,6-Difluoroaniline
5509-65-9
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,6-Difluoroaniline
5509-65-9
- $0.00
- 99
- Gansu Jinyuantai New Material Co., Ltd.
-
- 2,6-Difluoroaniline
5509-65-9
- $3.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,6-Difluoroaniline
5509-65-9
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
5509-65-9 (2,6-Difluoroaniline) Related Search:
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2,6-DIFLUOROANILINE
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6-Difluoroaniline
2-Amino-1,3-difluorobenzene
2,6-Difluoroaniline, 97% 5ML
JACS-5509-65-9
2,6- twofluoro aniline
2,6-Difluoroaniline 98%, 6-Difluoroaniline 98%
2,6-Difluoroaniline 98% Min.
2,6-Difluoroaniline>
2,6-Difluoroaniline ISO 9001：2015 REACH
Abemaciclib Impurity 9
Vandetanib Impurity 13
Abesili Impurity 8
2,6-Difluoroaniline, 96%
26DFA
2,6-DifluorobenzeneaMine
2,6-DifluorophenylaMine
2,6-DIFLUOROBENZENAMINE
5509-65-9
F2C6H3NH2
C6F2H5N1
C2 to C6
Amines
Building Blocks
Organic Building Blocks
Nitrogen Compounds
Anilines, Aromatic Amines and Nitro Compounds
Fluorobenzene
Miscellaneous
Fluorobenzene Series
Amines
C2 to C6
Nitrogen Compounds
bc0001
