(R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine
- CAS No.
- 930782-89-1
- Chemical Name:
- (R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine
- Synonyms
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE;(R)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine;(R)-4-Benzyl 1-tert-butyl 2-(hydroxyMethyl)piperazine-1,4-dicarboxylate;4-O-benzyl 1-O-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate;Benzyl 1-((tert-butoxy)carbonyl)-(2R)-2-(hydroxymethyl)piperazine-4-carboxylate;(R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester;1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-
- CBNumber:
- CB51118699
- Molecular Formula:
- C18H26N2O5
- Molecular Weight:
- 350.41
- MDL Number:
- MFCD17676317
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | B38979 | (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 95+% | 930782-89-1 | 100mg | $44 | 2026-05-06 | Buy |
| Synthonix | B38979 | (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 95+% | 930782-89-1 | 250mg | $50 | 2026-05-06 | Buy |
| Synthonix | B38979 | (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 95+% | 930782-89-1 | 1g | $80 | 2026-05-06 | Buy |
| Synthonix | B38979 | (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 95+% | 930782-89-1 | 5g | $320 | 2026-05-06 | Buy |
| aablocks | AA00GSJN | (R)-4-Benzyl 1-Tert-Butyl 2-(Hydroxymethyl)Piperazine-1,4-Dicarboxylate 97% | 930782-89-1 | 100mg | $23 | 2026-05-28 | Buy |
(R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine Chemical Properties, Uses, Production
Synthesis
138775-02-7
930782-89-1
General procedure for the synthesis of R-4-Boc-1-Cbz-2-hydroxymethylpiperazine from (R)-N-1-Boc-N-4-Cbz-2-piperazinecarboxylic acid: (2R)-4-[(phenylmethoxy)carbonyl]-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.4 g, 3.9 mmol) was dissolved in dimethoxyethane (10 mL), cooled, and N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution. N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution, followed by isobutyl chloroformate (0.54 g, 3.9 mmol). The reaction mixture was stirred at 0 °C for 20 min and then filtered. The filtrate was transferred to a 500 mL flask and cooled again. Sodium borohydride (0.22 g, 5.9 mmol) dissolved in water (5 mL) was added to the cooled filtrate and the external cooling bath was removed. The reaction mixture was stirred until its temperature rose to room temperature, then water (120 mL) was added. The mixture was extracted three times with ethyl acetate, the organic phases were combined, dried and the solvent evaporated. The product was purified by silica gel column chromatography (eluent: ethyl acetate/heptane, 10% to 70% gradient elution) to afford 1.2 g (84% yield) of 4-benzyl 1-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate as a colorless oil.1H NMR (500 MHz, CDCl3): δ 1.4 (s, 9H), 2.7-3.2 (b , 4H), 3.5 (b, 2H), 3.8-4.2 (m, 4H), 5.1 (m, 2H), 7.2-7.4 (m, 5H); LCMS: m/z 349 (M-1).
References
[1] Patent: WO2007/37743, 2007, A1. Location in patent: Page/Page column 47
(R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1998 | 55 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Chengdu AiQun Pharmaceutical Technology Co., Ltd. | 028-82393420 18108156287 | 2982653826@qq.com | China | 624 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Shanghai Jifeng Biotechnology Co., Ltd. | 021-61263377 15023907684 | 15800684150@163.com | China | 7994 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9389 | 58 |
View Latest Price from (R)-4-Boc-1-Cbz-2-hydroxymethylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate
930782-89-1
|
$2.00-6.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2019-12-24 | (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
930782-89-1
|
$1.00 | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co | |
 |
2019-12-24 | (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
930782-89-1
|
$1.00 | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate
930782-89-1
- $2.00-6.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
930782-89-1
- $1.00
- 97%-99.9%
- Career Henan Chemical Co
-
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
930782-89-1
- $1.00
- 97%-99.9%
- Career Henan Chemical Co
