1-Boc-3-hydroxymethyl-piperazine
- CAS No.
- 301673-16-5
- Chemical Name:
- 1-Boc-3-hydroxymethyl-piperazine
- Synonyms
- tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;1-Boc-3-hydroxymethyl-piperazine;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE;4-N-Bo;1-BOC-3-hydroxymethypiperazine;N-BOC-3-HYDROXYMETHYLPIPERAZINE;4-Boc-2-hydroxymethyl-piperazine;1-N-BOC-3-HYDROXYMETHYLPIPERAZINE;1-N-Boc-3-hydroxymethylpiperazine 98%;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl
- CBNumber:
- CB9726620
- Molecular Formula:
- C10H20N2O3
- Molecular Weight:
- 216.28
- MDL Number:
- MFCD04115304
- MOL File:
- 301673-16-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 93.0 to 97.0 °C |
|---|---|
| Boiling point | 322.9±22.0 °C(Predicted) |
| Density | 1.085±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 14.97±0.10(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 301673-16-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 2939800000 |
1-Boc-3-hydroxymethyl-piperazine price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4716 | 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine >98.0%(GC)(T) | 301673-16-5 | 200mg | $147 | 2024-03-01 | Buy |
| TCI Chemical | B4716 | 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine >98.0%(GC)(T) | 301673-16-5 | 1g | $635 | 2023-06-20 | Buy |
| AstaTech | 56820 | 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 301673-16-5 | 1G | $29 | 2026-04-30 | Buy |
| AstaTech | 56820 | 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 301673-16-5 | 5G | $59 | 2026-04-30 | Buy |
| AstaTech | 56820 | 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 301673-16-5 | 10G | $99 | 2026-04-30 | Buy |
1-Boc-3-hydroxymethyl-piperazine Chemical Properties, Uses, Production
Uses
1-Boc-3-Hydroxymethylpiperazine is an organic compound commonly used as an organic synthesis intermediate and pharmaceutical intermediate.
Synthesis
143540-05-0
301673-16-5
General procedure for the synthesis of 1-BOC-3-hydroxymethylpiperazine from 1,4-bis(Boc)-2-piperazinemethanol: To a solution of di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (4.00 g, 12.6 mmol) in ethanol (110 ml) was added sodium hydroxide (1.99 g, 49.8 mmol), and the mixture was heated under reflux conditions for 16 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was poured into water and the mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the target product 1-BOC-3-hydroxymethylpiperazine (2.71 g, 99.6% yield) as a solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 1.46 (9H, s), 2.12 (1H, br s), 2.64-3.01 (6H, br s), 3.47-3.53 (1H, m), 3.62-3.67 (1H, m), 3.89 (2H, br s).
References
[1] Patent: US2009/318412, 2009, A1. Location in patent: Page/Page column 34-35
[2] Patent: EP1338595, 2003, A2
1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Sichuan Guanghan Bio-Tech Co., Ltd | +86-28-86127071 | info@sino-produce.com | China | 400 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 1-Boc-3-hydroxymethyl-piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-09 | 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co | |
 |
2019-07-11 | 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
|
$1.00 | 1KG | 98% | 1kg，5kg，100kg | Career Henan Chemical Co |
-
- 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
- $8.80
- 97%-99%
- Career Henan Chemical Co
-
- 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
- $1.00
- 98%
- Career Henan Chemical Co
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