ChemicalBook >> CAS DataBase List >>CUCURBITACIN B
CUCURBITACIN B
- CAS No.
- 6199-67-3
- Chemical Name:
- CUCURBITACIN B
- Synonyms
- Cucurbitacin;Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;cucuritacin B;cucurbitacineb;CUCURBITACIN B
- CBNumber:
- CB5113260
- Molecular Formula:
- C32H46O8
- Molecular Weight:
- 558.7
- MDL Number:
- MFCD07778083
- MOL File:
- 6199-67-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
| Melting point | 184-186° |
|---|---|
| alpha | D25 +88° (c = 1.55 in ethanol) |
| Boiling point | 546.74°C (rough estimate) |
| Density | 1.0953 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 12.60±0.29(Predicted) |
| color | white to beige |
| λmax | 290nm(EtOH)(lit.) |
| Merck | 14,2614 |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChIKey | IXQKXEUSCPEQRD-ALLWXVAWSA-N |
| SMILES | CC1(C)C([C@@H](O)C[C@]2([H])C1=CC[C@]([C@@](C[C@@H](O)[C@]3([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)(C)[C@]3(C)C4)([H])[C@@]2(C)C4=O)=O |
| FDA UNII | 0115W5MABF |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45-24/25 | |||||||||
| RIDADR | UN 2811 6.1 / PGI | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC6190000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29153900 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Oral | |||||||||
| Hazardous Substances Data | 6199-67-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD10 orally in mice: 5 mg/kg (LeMen) | |||||||||
| NFPA 704 |
|
CUCURBITACIN B price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8499 | Cucurbitacin B hydrate ≥97% (HPLC) | 6199-67-3 | 5mg | $282 | 2026-04-30 | Buy |
| Sigma-Aldrich | C8499 | Cucurbitacin B hydrate ≥97% (HPLC) | 6199-67-3 | 25mg | $1130 | 2026-04-30 | Buy |
| TCI Chemical | C3442 | Cucurbitacin B >98.0%(HPLC) | 6199-67-3 | 5mg | $111 | 2026-04-30 | Buy |
| TCI Chemical | C3442 | Cucurbitacin B >98.0%(HPLC) | 6199-67-3 | 25mg | $386 | 2026-04-30 | Buy |
| Cayman Chemical | 14820 | Cucurbitacin B ≥98% | 6199-67-3 | 1mg | $41 | 2026-04-30 | Buy |
CUCURBITACIN B Chemical Properties, Uses, Production
Description
Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.
Chemical Properties
White solid
Uses
Cucurbitacin B hydrate has been used:
- as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
- as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
- to determine its effect on the cell viability of pancreatic cancer cell lines.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
Biochem/physiol Actions
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
CUCURBITACIN B Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 318)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei wei shi reagent group ltd., company | 17771898297 13125137661 | 2853877621@qq.com | China | 7992 | 58 |
| Hubei CuiRan Biotechnology Co., Ltd. | 18162795156 18162795156 | 3391961471@qq.com | China | 4967 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from CUCURBITACIN B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Cucurbitacin B
6199-67-3
|
1KG | Cucurbitacin B≥60% | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-14 | Cucurbitacin
6199-67-3
|
1kg | 98% | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-09-13 | Cucurbitacin B
6199-67-3
|
$44.00-167.00 | 99.93% | 10g | TargetMol Chemicals Inc. |
-
- Cucurbitacin B
6199-67-3
- $0.00
- Cucurbitacin B≥60%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Cucurbitacin
6199-67-3
- 98%
- Sinoway Industrial co., ltd.
-
- Cucurbitacin B
6199-67-3
- $44.00-167.00
- 99.93%
- TargetMol Chemicals Inc.
6199-67-3 (CUCURBITACIN B) Related Search:
(2beta,9beta,10alpha,16alpha,23e)-thyl
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19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet
19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me
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cucuritacin B
(+)-Cucurbitacin B
(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
1,2-Dihydro-a-elaterin
Cucurbitacin B-RM
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Cucurbitacin B hydrate[C8499]
Cucurbitacin B (Standard)
Cucurbitacin
6199-67-3
C32H46O8
Tri-Terpenoids
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract
