2,3-Dihydro-1H-benz[e]inden-1-one
![2,3-Dihydro-1H-benz[e]inden-1-one Structure](CAS/GIF/6342-87-6.gif)
- CAS No.
- 6342-87-6
- Chemical Name:
- 2,3-Dihydro-1H-benz[e]inden-1-one
- Synonyms
- 2,3-Dihydro-1H-cyclopenta[a]naphthalen-1-one;2,3-Dihydro-1H-benz[e]inden-1-one;1H-Benz[e]inden-1-one, 2,3-dihydro-;2,3-DIHYDRO-CYCLOPENTA[A]NAPHTHALEN-1-ONE;(S)-2-amino-1-(3,5-dimethylphenyl)ethan-1-ol;2,3-dihydro-1H-cyclopentyldienebenzo[a]1-tetralone
- CBNumber:
- CB5115628
- Molecular Formula:
- C13H10O
- Molecular Weight:
- 182.22
- MDL Number:
- MFCD00466286
- MOL File:
- 6342-87-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2,3-Dihydro-1H-benz[e]inden-1-one price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS25074 | 2,3-Dihydro-1H-benz[e]inden-1-one 95% | 6342-87-6 | 1g | $105 | 2026-06-04 | Buy |
| Activate Scientific | AS25074 | 2,3-Dihydro-1H-benz[e]inden-1-one 95% | 6342-87-6 | 5g | $314 | 2026-06-04 | Buy |
| Matrix Scientific | 292675 | 2,3-Dihydro-1H-cyclopenta[a]naphthalen-1-one | 6342-87-6 | 250.00mg | $36 | 2026-05-19 | Buy |
| Matrix Scientific | 292675 | 2,3-Dihydro-1H-cyclopenta[a]naphthalen-1-one | 6342-87-6 | 1.00g | $124 | 2026-05-19 | Buy |
| Matrix Scientific | 292675 | 2,3-Dihydro-1H-cyclopenta[a]naphthalen-1-one | 6342-87-6 | 5.00g | $582 | 2026-05-19 | Buy |
2,3-Dihydro-1H-benz[e]inden-1-one Chemical Properties, Uses, Production
Synthesis
21658-35-5
![2,3-DIHYDRO-1H-BENZ[E]INDEN-1-ONE](/CAS/GIF/6342-87-6.gif)
6342-87-6
In a flask equipped with a mechanical stirrer, Eaton's reagent prepared by adding 144.0 g of P4O10 and 840 mL of methanesulfonic acid was added in batches at room temperature. Subsequently, 144.0 g (~720 mmol) of 3-(2-naphthyl)propionic acid was added to the system. The reaction mixture was stirred overnight and then slowly poured into 2 L of ice-cold water to quench the reaction. The crude product was extracted with 3 x 500 mL dichloromethane and the organic phases were combined. The organic phase was washed sequentially with aqueous K2CO3, dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was purified by fast column chromatography using 600 mL silica gel 60 (40-63 μm) as stationary phase and hexane and dichloromethane (1:1, v/v) as eluent to afford 105.0 g (80% yield) of the target compound, 2,3-dihydro-1H-benzo[e]inden-1-one, as a brown solid. Elemental analysis (C13H10O) Calculated values: C, 85.69; H, 5.53. Measured values: C, 85.98; H, 5.75. 1H NMR (CDCl3) δ: 9.12 (d, J = 8.5 Hz, 1H), 7.93 (d, J = 8.3 Hz, 1H), 7.81 (d, J = 8.1 Hz, 1H), 7.61 (ddd , J = 8.3, 7.1, 1.2 Hz, 1H), 7.50 (ddd, J = 8.1, 7.1, 1.0 Hz, 1H), 7.39 (d, J = 8.3 Hz, 1H), 3.12-3.04 (m, 2H), 2.75-2.65 (m, 2H). 13C{1H} NMR (CDCl3) δ: 207.26, 158.26, 135.47 158.26, 135.47, 132.41, 130.81, 129.23, 128.65, 127.90, 126.39, 123.87, 123.76, 36.73, 25.99.
References
[1] Journal of the American Chemical Society, 2001, vol. 123, # 14, p. 3214 - 3222
[2] Chemistry - A European Journal, 2015, vol. 21, # 37, p. 13052 - 13057
[3] Patent: WO2017/118617, 2017, A1. Location in patent: Page/Page column 20
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 1845 - 1848
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983, vol. 22, # 10, p. 1015 - 1019
2,3-Dihydro-1H-benz[e]inden-1-one Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Bejing Famous Pharmaceutical Technology Co., Ltd. | 010-80339217; 13331045123 | 2559355526@qq.com | China | 14180 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20535 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
