BQ-3020
- CAS No.
- 143113-45-5
- Chemical Name:
- BQ-3020
- Synonyms
- BQ-3020;BQ-3020 TFA salt;AC-LMDKEAVYFAHLDIIW;M.W. 2006.35 C96H140N20O25S;Acetyl-(Ala 11,15)-ET 1 (6-21);endothelin receptor antagonist;AC-(ALA11,15)-ENDOTHELIN-1 (6-21);N-AC, ALA11,15-ENDOTHELIN 1, 6-21;ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21);ACETYL-(D-TRP16)-ENDOTHELIN-1 (16-21)
- CBNumber:
- CB5117455
- Molecular Formula:
- C96H140N20O25S
- Molecular Weight:
- 2006.34
- MDL Number:
- MFCD00236977
- MOL File:
- 143113-45-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 2125.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.287±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M) |
| form | powder |
| pka | 3.39±0.10(Predicted) |
| color | white |
| Sensitive | Light Sensitive |
| Sequence | Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH |
| InChIKey | NUAGCEFLVCODRQ-KETPNHLCSA-N |
| NCI Dictionary of Cancer Terms | endothelin receptor antagonist |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H302-H332 |
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 |
| WGK Germany | 3 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Inhalation Acute Tox. 1 Oral |
BQ-3020 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SCP0138 | BQ-3020 ≥97% (HPLC) | 143113-45-5 | 1mg | $434 | 2026-04-30 | Buy |
| Sigma-Aldrich | SCP0138 | BQ-3020 | 143113-45-5 | 500μg | $284 | 2025-07-31 | Buy |
| Usbiological | 254811 | BQ-3020 Asreported | 143113-45-5 | 500ug | $516 | 2026-06-03 | Buy |
| Biosynth | FA110316 | Acetyl-(Ala11·15)-Endothelin-1 (6-21) | 143113-45-5 | 1000ug | $900 | 2026-06-04 | Buy |
| Biosynth | FA110316 | Acetyl-(Ala11·15)-Endothelin-1 (6-21) | 143113-45-5 | 500ug | $900 | 2026-06-04 | Buy |
BQ-3020 Chemical Properties,Uses,Production
Uses
BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.
Biological Activity
BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.
in vivo
BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model[3].
| Animal Model: | Cancer pain mouse model [3] |
| Dosage: | 3 mg/kg |
| Administration: | Injected subcutaneously at the site of the greatest tumor development |
| Result: | Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection |
IC 50
ETB: 0.2 nM (IC50)
storage
-20°C
References
[1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009
BQ-3020 Preparation Products And Raw materials
Raw materials
Preparation Products
BQ-3020 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
