BQ-3020
- CAS No.
- 143113-45-5
- Chemical Name:
- BQ-3020
- Synonyms
- BQ-3020;BQ-3020 TFA salt;AC-LMDKEAVYFAHLDIIW;M.W. 2006.35 C96H140N20O25S;Acetyl-(Ala 11,15)-ET 1 (6-21);endothelin receptor antagonist;AC-(ALA11,15)-ENDOTHELIN-1 (6-21);N-AC, ALA11,15-ENDOTHELIN 1, 6-21;ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21);ACETYL-(D-TRP16)-ENDOTHELIN-1 (16-21)
- CBNumber:
- CB5117455
- Molecular Formula:
- C96H140N20O25S
- Molecular Weight:
- 2006.34
- MDL Number:
- MFCD00236977
- MOL File:
- 143113-45-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BQ-3020 ≥97% (HPLC) | SCP0138 | 1mg | $434 |
| BQ-3020 | SCP0138 | 500μg | $284 |
| BQ-3020 Asreported | 254811 | 500ug | $516 |
| Acetyl-(Ala11·15)-Endothelin-1 (6-21) | FA110316 | 1000ug | $900 |
| Acetyl-(Ala11·15)-Endothelin-1 (6-21) | FA110316 | 500ug | $900 |
| Boiling point | 2125.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.287±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M) |
| form | powder |
| pka | 3.39±0.10(Predicted) |
| color | white |
| Sensitive | Light Sensitive |
| Sequence | Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH |
| InChIKey | NUAGCEFLVCODRQ-KETPNHLCSA-N |
| NCI Dictionary of Cancer Terms | endothelin receptor antagonist |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H302-H332 |
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 |
| WGK Germany | 3 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Inhalation Acute Tox. 1 Oral |
BQ-3020 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SCP0138 | BQ-3020 ≥97% (HPLC) | 143113-45-5 | 1mg | $434 | 2026-04-30 | Buy |
| Sigma-Aldrich | SCP0138 | BQ-3020 | 143113-45-5 | 500μg | $284 | 2025-07-31 | Buy |
| Usbiological | 254811 | BQ-3020 Asreported | 143113-45-5 | 500ug | $516 | 2026-06-03 | Buy |
| Biosynth | FA110316 | Acetyl-(Ala11·15)-Endothelin-1 (6-21) | 143113-45-5 | 1000ug | $900 | 2026-06-04 | Buy |
| Biosynth | FA110316 | Acetyl-(Ala11·15)-Endothelin-1 (6-21) | 143113-45-5 | 500ug | $900 | 2026-06-04 | Buy |
BQ-3020 Chemical Properties,Uses,Production
Uses
BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.
Biological Activity
BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.
in vivo
BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model[3].
| Animal Model: | Cancer pain mouse model [3] |
| Dosage: | 3 mg/kg |
| Administration: | Injected subcutaneously at the site of the greatest tumor development |
| Result: | Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection |
IC 50
ETB: 0.2 nM (IC50)
storage
-20°C
References
[1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009
BQ-3020 Preparation Products And Raw materials
Raw materials
Preparation Products
BQ-3020 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10457 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Nanjing TGpeptide | +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
