PNU 109291
- CAS No.
- 187665-60-7
- Chemical Name:
- PNU 109291
- Synonyms
- PNU 109291;(S)-3,4-DIHYDRO-1-[2-[4-(4-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE;1H-2-Benzopyran-6-carboxamide, 3,4-dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-, (1S)-
- CBNumber:
- CB51311032
- Molecular Formula:
- C24H31N3O3
- Molecular Weight:
- 409.52
- MDL Number:
- MFCD10687095
- MOL File:
- 187665-60-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 595.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.143±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| form | Powder |
| pka | 15.27±0.40(Predicted) |
| FDA UNII | 6E4LJL8K38 |
PNU 109291 price More Price(2)
PNU 109291 Chemical Properties, Uses, Production
Uses
PNU 109291 is a 5-HT receptor agonist.
Biological Activity
Potent and selective 5-HT 1D receptor agonist that displays > 600-fold selectivity over 5-HT 1A and 5-HT 2A receptors and no activity at 5-HT 1B , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 6 and 5-HT 7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.
in vivo
PNU109291 (0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg; s.c.) reduces dural plasma extravasation evoked by trigeminal ganglion stimulation in pigs[1].
PNU109291 (3 μM) inhibited evoked EPSCs (excitatory postsynaptic currents) in Freund's adjuvant (CFA) but not saline-injected rats[2].
| Animal Model: | 200-500g, male Hartley guinea pigs[1] |
| Dosage: | 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg |
| Administration: | S.c.; 60 min before electrical stimulation |
| Result: | Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg. |
PNU 109291 Preparation Products And Raw materials
Raw materials
Preparation Products
PNU 109291 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19684 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| EMMX Biotechnology LLC | 60 |
| TargetMol Chemicals Inc. | 58 |
| Jinan ponder chemical co. LTD | 58 |
| Energy Chemical | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
