Loxoprofen sodium
- CAS No.
- 80382-23-6
- Chemical Name:
- Loxoprofen sodium
- Synonyms
- Loxoprofen sodiuM hydrate;Loxonin;LOXOPROFEN NA;LXP;cs-600;loxoprofern sodium;Loxoprofen Sodium impurity;Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate;Unastin;Dipyridame
- CBNumber:
- CB5138100
- Molecular Formula:
- C15H19NaO3
- Molecular Weight:
- 270.3
- MDL Number:
- MFCD00941425
- MOL File:
- 80382-23-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | DMSO: soluble |
| form | A solid |
| color | White to off-white |
| InChI | InChI=1S/C15H18O3.Na.H/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);; |
| InChIKey | ALZXNWUYLUBHJL-UHFFFAOYSA-N |
| SMILES | C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1.[NaH] |
| CAS DataBase Reference | 80382-23-6(CAS DataBase Reference) |
| FDA UNII | NDC2M7399S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
Loxoprofen sodium price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 35088 | Loxoprofen (sodium salt) ≥98% | 80382-23-6 | 1g | $62 | 2026-04-30 | Buy |
| Cayman Chemical | 35088 | Loxoprofen (sodium salt) ≥98% | 80382-23-6 | 5g | $117 | 2026-04-30 | Buy |
| TRC | TRC-L472900-5G | Loxoprofen Sodium (Mixture of diastereomers) | 80382-23-6 | 5g | $116 | 2026-06-03 | Buy |
| TRC | TRC-L472900-25MG | Loxoprofen Sodium (Mixture of diastereomers) | 80382-23-6 | 25mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-L472900-250MG | Loxoprofen Sodium (Mixture of diastereomers) | 80382-23-6 | 250mg | $78 | 2026-06-03 | Buy |
Loxoprofen sodium Chemical Properties,Uses,Production
Description
Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity.
Originator
Sankyo (Japan)
Uses
anti-inflammatory
Definition
ChEBI: A hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.
brand name
LOXONIN
Mechanism of action
As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.
Side effects
Adverse effects include anorexia, nausea, vomiting, bleeding, anemia, diarrhea, and constipation.
Synthesis
68767-14-6
80382-23-6
General procedure for the synthesis of sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionate from 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid: 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid and methanol were added into a round-bottomed flask, and 1 equivalent of aqueous sodium hydroxide was added to the above solution drop by drop, and the reaction was stirred for 1 hour at room temperature. Upon completion of the reaction, a decompression distillation was carried out at 50-55°C to remove the solvent. Subsequently, a 5% aqueous solution of ethyl acetate was added to the residue, heated until dissolved and then slowly cooled to room temperature. Crystallization was induced by the addition of crystal seeds during cooling and stirring was continued for 5-6 hours at 0-5°C until a suspension was formed. Finally, the solid was collected by filtration to give loxoprofen sodium dihydrate in 95% yield and 99.1% HPLC purity.
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7879 - 7882
[2] Patent: CN107176942, 2017, A. Location in patent: Paragraph 0067; 0068; 0069
[3] Patent: CN108440274, 2018, A. Location in patent: Paragraph 0076; 0077; 0078; 0079; 0080
Loxoprofen sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Penglei Biological Technology Co., Ltd. | 18672616696 | 229092275@qq.com | China | 706 | 58 |
| Wuhan haorong Biotechnology Co., Ltd | 13217229939 | 773651767@qq.com | China | 4498 | 58 |
| Huzhou Qingliu Silicate Biotechnology Co., Ltd | 13626726938 | 15952452933@163.cn | China | 4111 | 58 |
| Hubei Hengshuo Chemical Co. Ltd. | 027-82830253 13995541600 | hengshuohg@163.com | China | 494 | 58 |
| Jiangsu Rongshuo Pharmaceutical Co., Ltd | 0000-15105138935 15105138935 | 2622104407@qq.com | China | 99 | 58 |
| Shandong Mingfeng Pharmaceutical and Technology Co. Ltd | 053155551677 15315114555 | 1345456643@qq.com | China | 298 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 94607 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
Related articles
- Synthesis and Precautions for the Use of Loxoprofen Sodium
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- Feb 7,2025
View Lastest Price from Loxoprofen sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | Loxoprofen sodium
80382-23-6
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | Loxoprofen sodium
80382-23-6
|
1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-21 | Loxoprofen sodium
80382-23-6
|
$92.00-100.00 | 1kilograms | 99% | 100tons | Hebei Dangtong Import and export Co LTD |
-
- Loxoprofen sodium
80382-23-6
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Loxoprofen sodium
80382-23-6
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Loxoprofen sodium
80382-23-6
- $92.00-100.00
- 99%
- Hebei Dangtong Import and export Co LTD
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