2-(4-Bromomethyl)phenylpropionic acid
- CAS No.
- 111128-12-2
- Chemical Name:
- 2-(4-Bromomethyl)phenylpropionic acid
- Synonyms
- BMPPA;2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID;2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID;Loxoprofen 16;Loxoprofen sodium 16;Loxoprofen Impurity 28;Loxoprofen Intermediate;p-Bromomethyl isocyanate;Loxoprofen Sodium intermediate;4-(BROMOMETHYL)HYDRATROPIC ACID
- CBNumber:
- CB3420139
- Molecular Formula:
- C10H11BrO2
- Molecular Weight:
- 243.1
- MDL Number:
- MFCD02093445
- MOL File:
- 111128-12-2.mol
- MSDS File:
- SDS
| Melting point | 126-130 °C(lit.) |
|---|---|
| Boiling point | 148°C (rough estimate) |
| Density | 1.4557 (rough estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | powder to crystal |
| pka | 4.29±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C10H11BrO2/c1-7(10(12)13)9-4-2-8(6-11)3-5-9/h2-5,7H,6H2,1H3,(H,12,13) |
| InChIKey | QQXBRVQJMKBAOZ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(C1=CC=C(CBr)C=C1)C |
| CAS DataBase Reference | 111128-12-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-36/37/38 | |||||||||
| Safety Statements | 26-27-36/37/39-45-37/39 | |||||||||
| RIDADR | UN 1759 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅱ | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
2-(4-Bromomethyl)phenylpropionic acid price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 530360 | 2-[4-(Bromomethyl)phenyl]propionic acid 96% | 111128-12-2 | 25g | $537 | 2023-06-20 | Buy |
| TCI Chemical | B2101 | 2-[4-(Bromomethyl)phenyl]propionic Acid >98.0%(T) | 111128-12-2 | 5g | $61 | 2025-07-31 | Buy |
| TCI Chemical | B2101 | 2-[4-(Bromomethyl)phenyl]propionic Acid >98.0%(T) | 111128-12-2 | 25g | $186 | 2025-07-31 | Buy |
| TRC | B415946 | 2-[4-(Bromomethyl)phenyl]propionic acid | 111128-12-2 | 100g | $125 | 2021-12-16 | Buy |
| TRC | B415946 | 2-[4-(Bromomethyl)phenyl]propionic acid | 111128-12-2 | 10g | $65 | 2021-12-16 | Buy |
2-(4-Bromomethyl)phenylpropionic acid Chemical Properties,Uses,Production
Chemical Properties
beige-cream crystalline powder
Uses
2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.
General Description
2-[4-(Bromomethyl)phenyl]propionic acid is a propionic acid derivative. Its enthalpy of vaporization at boiling point (421.15K) is 36.363kjoule/mol and density at 25°C is 1.4212g/ml.
Synthesis
The synthesis method comprises the following steps: dissolving sodium hydroxide in excessive methanol to react with p-chloro-tolualdehyde to obtain p-methoxy-tolualdehyde, andthen performing chloromethylation reaction on the p-methoxy tolualdehyde and concentrated hydrochloric acid in the existence of sulfuric acid to obtain p-chloromethyl benzyl ether; performing nucleophilic reaction on the p-chloromethyl benzyl ether and the sodium cyanide to obtain p-methoxy-methyl benzyl cyanide; reacting the p-methoxy-methyl benzyl cyanide with dimethyl carbonate under high pressure in the existence of a catalyst to obtain p-methoxy-methyl benzyl iso-propionitrile; and reacting the p-methoxy-methylbenzyl sodium isopropionate with excessive concentrate sulfuric acid to generate molten salt which is reacted with hydrobromic acid to obtain 2-(4-Bromomethyl)phenylpropionic acid.
References
[1] Patent: CN104744237, 2016, B. Location in patent: Paragraph 0027; 0042; 0048; 0049
[2] Patent: CN105753685, 2016, A. Location in patent: Paragraph 0104; 0105
[3] Patent: CN106866404, 2017, A. Location in patent: Paragraph 0013
[4] Patent: CN107573230, 2018, A. Location in patent: Paragraph 0024; 0025; 0026; 0027; 0028; 0029; 0030; 0031
2-(4-Bromomethyl)phenylpropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TAIZHOU DKD CHEMICAL CO., LTD. | +8618658336633 | yf.chen@tzdkdchem.com | China | 134 | 58 |
| Anhuyan (Hainan) Biotechnology Co., LTD | +86-18163349544; +8618163349544 | mollylucking@foxmail.com | China | 3000 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12891 | 58 |
View Lastest Price from 2-(4-Bromomethyl)phenylpropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-12 | 2-(4-Bromomethyl)phenylpropionic acid
111128-12-2
|
US $0.00 / Kg/Drum | 1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-08-08 | 2-(4-Bromomethyl)phenylpropionic acid
111128-12-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | 2-(4-Bromomethyl)phenylpropionic acid
111128-12-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-(4-Bromomethyl)phenylpropionic acid
111128-12-2
- US $0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-(4-Bromomethyl)phenylpropionic acid
111128-12-2
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2-(4-Bromomethyl)phenylpropionic acid
111128-12-2
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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