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2-Fluoro-5-nitroanisole

2-Fluoro-5-nitroanisole structure

CAS No.: 454-16-0

Chemical Name:: 2-Fluoro-5-nitroanisole

Synonyms: 1-Fluoro-2-methoxy-4-nitrobenzene;2-Fluoro-5-nitroasinole;2-Fluoro-5-nitroanisole;4-Fluoro-3-methoxynitrobenzene;3-Methoxy-4-fluoronitrobenzene;Anisole, 2-fluoro-5-nitro- (8CI);Benzene, 1-fluoro-2-methoxy-4-nitro-;4-Fluoro-3-methoxynitrobenzene 2-Fluoro-5-nitroanisole;2-Fluoro-5-nitroanisole[4-Fluoro-3-Methoxynitrobenzene];4-Fluoro-3-methoxynitrobenzene, 1-Fluoro-2-methoxy-4-nitrobenzene, 2-Fluoro-5-nitrophenyl methyl ether

CBNumber:: CB51466501

Molecular Formula:: C7H6FNO3

Molecular Weight:: 171.13

MDL Number:: MFCD07782081

MOL File:: 454-16-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:25:46

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2-Fluoro-5-nitroanisole Properties

Melting point	69-71 °C
Boiling point	270.3±20.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	Light Yellow to Yellow
InChI	InChI=1S/C7H6FNO3/c1-12-7-4-5(9(10)11)2-3-6(7)8/h2-4H,1H3
InChIKey	AZNKKZHZGDZSIF-UHFFFAOYSA-N
SMILES	C1(F)=CC=C([N+]([O-])=O)C=C1OC

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
HS Code	2909309090

2-Fluoro-5-nitroanisole price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-F597580-500MG	2-Fluoro-5-nitroanisole	454-16-0	500mg	$84	2026-06-03	Buy
TRC	TRC-F597580-250MG	2-Fluoro-5-nitroanisole	454-16-0	250mg	$72	2026-06-03	Buy
TRC	TRC-F597580-100MG	2-Fluoro-5-nitroanisole	454-16-0	100mg	$65	2026-06-03	Buy
Biosynth	FF33946	2-Fluoro-5-nitroanisole	454-16-0	50g	$150	2026-06-04	Buy
Biosynth	FF33946	2-Fluoro-5-nitroanisole	454-16-0	25g	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-F597580-500MG	500mg	$84	Buy
TRC-F597580-250MG	250mg	$72	Buy
TRC-F597580-100MG	100mg	$65	Buy
FF33946	50g	$150	Buy
FF33946	25g	$150	Buy

2-Fluoro-5-nitroanisole Chemical Properties, Uses, Production

Synthesis

22510-08-3

74-88-4

454-16-0

GENERAL STEPS: Potassium carbonate (K2CO3, 5.27 g, 38.1 mmol) was added to a solution of 2-fluoro-5-nitrophenol (5.0 g, 31.84 mmol) in N,N-dimethylformamide (DMF, 50 mL), and the mixture was stirred for 15 minutes at room temperature. Subsequently, iodomethane (3 mL, 47.7 mmol) was added and the reaction mixture continued to be stirred for 2 hours at room temperature. Upon completion of the reaction, the mixture was poured into ice water and the solid product was isolated by filtration. The solid was washed well with deionized water and subsequently dried under vacuum to afford the off-white solid product 2-fluoro-5-nitroanisole (4.0 g, 73.5% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.89-7.84 (m, 2H), 7.25-7.17 (m, 1H), 3.98 (s, 3H).

References

[1] Patent: WO2015/104653, 2015, A1. Location in patent: Page/Page column 57
[2] Patent: US2016/368906, 2016, A1. Location in patent: Paragraph 0229
[3] Patent: US2014/57911, 2014, A1. Location in patent: Paragraph 0635

2-Fluoro-5-nitroanisole Preparation Products And Raw materials

Raw materials

2-Fluoro-5-nitrophenol Iodomethane Potassium carbonate N,N-Dimethylformamide

Preparation Products

tert-butyl 3-(2-methoxy-4-nitrophenoxy)azetidine-1-carboxylate

2-Fluoro-5-nitroanisole Suppliers

Global Suppliers ( 182)

Supplier	Tel	Email	Country	ProdList	Advantage
Encyclopedia Source (Chengdu) Technology Co., Ltd.	15021461747	446211270@qq.com	China	1335	58
WUXI SHUANGQI TECHNOLOGY CO LTD.	0510-86529556 18114865355	1702606491@qq.com	China	1104	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Encyclopedia Source (Chengdu) Technology Co., Ltd.	58
WUXI SHUANGQI TECHNOLOGY CO LTD.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Shanghai Longsheng chemical Co.,Ltd.	59
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 2-Fluoro-5-nitroanisole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	2-Fluoro-5-nitroanisole 454-16-0	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-02-02	2-Fluoro-5-nitroanisole 454-16-0		10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-04-08	2-Fluoro-5-nitroanisole 454-16-0	$890.00	1g	98	5000 Kg	R&D Scientific Inc.

2-Fluoro-5-nitroanisole
454-16-0
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Fluoro-5-nitroanisole
454-16-0
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

2-Fluoro-5-nitroanisole
454-16-0
$890.00
98
R&D Scientific Inc.

2-Fluoro-5-nitroanisole Spectrum

2-Fluoro-5-nitroanisole(454-16-0)¹HNMR 2-Fluoro-5-nitroanisole(454-16-0)¹⁹FNMR

454-16-0 (2-Fluoro-5-nitroanisole) Related Search:

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1of4

2-Fluoro-5-nitroanisole 3-Methoxy-4-fluoronitrobenzene 4-Fluoro-3-methoxynitrobenzene Anisole, 2-fluoro-5-nitro- (8CI) 4-Fluoro-3-methoxynitrobenzene, 1-Fluoro-2-methoxy-4-nitrobenzene, 2-Fluoro-5-nitrophenyl methyl ether 2-Fluoro-5-nitroanisole[4-Fluoro-3-Methoxynitrobenzene] Benzene, 1-fluoro-2-methoxy-4-nitro- 2-Fluoro-5-nitroasinole 4-Fluoro-3-methoxynitrobenzene 2-Fluoro-5-nitroanisole 1-Fluoro-2-methoxy-4-nitrobenzene 454-16-0 445-93-6 Multisubstituted Benzene Aromatic Halides (substituted)