4-Fluoro-2-nitroanisole
- CAS No.
- 445-83-0
- Chemical Name:
- 4-Fluoro-2-nitroanisole
- Synonyms
- 4-Fluoro-2-nitro-methoxybenzene;4-FLUORO-1-METHOXY-2-NITROBENZENE;4-Fluoro-2-nitroanis;4-FLUORO-2-NITROANISOLE;4-Fluoro-2-nitroanisole>4-Fluoro-2-nitroanisole98%;4-Fluoro-2-nitroanisole 98%;445-83-0 4-Fluoro-2-nitroanisole;1-Methoxy-2-nitro-4-fluorobenzene;Benzene, 4-fluoro-1-methoxy-2-nitro-
- CBNumber:
- CB2771333
- Molecular Formula:
- C7H6FNO3
- Molecular Weight:
- 171.13
- MDL Number:
- MFCD00013375
- MOL File:
- 445-83-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 62-64 °C (lit.) |
|---|---|
| Boiling point | 272.4±20.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Toluene |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| InChI | 1S/C7H6FNO3/c1-12-7-3-2-5(8)4-6(7)9(10)11/h2-4H,1H3 |
| InChIKey | FWLPYISRFBKEKV-UHFFFAOYSA-N |
| SMILES | COc1ccc(F)cc1[N+]([O-])=O |
| CAS DataBase Reference | 445-83-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
4-Fluoro-2-nitroanisole price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 324760 | 4-Fluoro-2-nitroanisole 98% | 445-83-0 | 5g | $56.7 | 2022-05-15 | Buy |
| TCI Chemical | F0615 | 4-Fluoro-2-nitroanisole >98.0%(GC) | 445-83-0 | 5g | $80 | 2026-04-30 | Buy |
| TCI Chemical | F0615 | 4-Fluoro-2-nitroanisole >98.0%(GC) | 445-83-0 | 25g | $253 | 2026-04-30 | Buy |
| Apolloscientific | PC3883 | 4-Fluoro-2-nitroanisole 98% | 445-83-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC3883 | 4-Fluoro-2-nitroanisole 98% | 445-83-0 | 25g | $28 | 2026-06-04 | Buy |
4-Fluoro-2-nitroanisole Chemical Properties, Uses, Production
Chemical Properties
Yellow powder
Uses
4-Fluoro-2-nitroanisole is formed during the photolysis of the charge transfer complex of tetranitromethane and 4-fluoroanisole in dichloromethane at -20°C.
General Description
4-Fluoro-2-nitroanisole is formed during the photolysis of the charge transfer complex of tetranitromethane and 4-fluoroanisole in dichloromethane at -20°C.
Synthesis
394-33-2
74-88-4
445-83-0
General procedure for the synthesis of 2-nitro-4-fluoroanisole from 2-nitro-4-fluorophenol and iodomethane: Acetonitrile (100 mL) solution of iodomethane (127.8 g, 0.9004 mol) was added slowly and dropwise to an acetonitrile (450 mL) solution containing 5-fluoro-2-nitrophenol (94.2 g, 0.600 mol) and potassium carbonate (207 g, 1.50 mol). mL) solution. The reaction mixture was heated to reflux for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove insoluble solids, and the filter cake was washed twice with dichloromethane (100 mL). The filtrate and washings were combined and the solvent was evaporated to dryness by rotary evaporator to afford the crude product 2-nitro-4-fluoroanisole (96 g, 0.56 mol, 93% yield), which could be used in subsequent reactions without further purification.
References
[1] Patent: WO2005/26137, 2005, A2. Location in patent: Page/Page column 230-231
[2] Synthetic Communications, 1989, vol. 19, # 1, 2, p. 233 - 238
4-Fluoro-2-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 4-Fluoro-2-nitroanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Fluoro-2-nitroanisole
445-83-0
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2026-02-02 | 4-Fluoro-2-nitroanisole
445-83-0
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2021-07-13 | 4-Fluoro-2-nitroanisole
445-83-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-Fluoro-2-nitroanisole
445-83-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Fluoro-2-nitroanisole
445-83-0
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-Fluoro-2-nitroanisole
445-83-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
