3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
- CAS No.
- 637031-93-7
- Chemical Name:
- 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
- Synonyms
- 3,3-difluorocyclobutan-1-aMine hydrochloride;3,3-difluorocyclobutanaMine hcl;3,3-Difluorocyclobutanami...;(3,3-difluorocyclobutyl)azanium;3,3-Difluoro-cyclobutylamine HCl salt;3,3-DIFLUOROCYCLOBUTAMINE HYDROCHLORIDE;3,3-Diflurocyclobutanamine hydrochloride;3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE;3,3-difluorocyclobutanamine'hydrochloride;(3,3-Difluorocyclobutyl)aMine Hydrochloride
- CBNumber:
- CB51517113
- Molecular Formula:
- C4H8ClF2N
- Molecular Weight:
- 143.56
- MDL Number:
- MFCD10001382
- MOL File:
- 637031-93-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,3-Difluorocyclobutanamine Hydrochloride | D5597 | 200MG | $33 |
| 3,3-Difluorocyclobutanamine Hydrochloride | D5597 | 1G | $99 |
| 3,3-Difluorocyclobutanamine Hydrochloride | TRC-D445980-5G | 5g | $167 |
| 3,3-Difluorocyclobutanamine Hydrochloride | TRC-D445980-1G | 1g | $65 |
| 3,3-Difluorocyclobutanamine hydrochloride 97% | PC405003 | 1g | $21 |
| More product size | |||
| Melting point | 296 °C |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C4H7F2N.ClH/c5-4(6)1-3(7)2-4;/h3H,1-2,7H2;1H |
| InChIKey | WLXXTHPAORBNIG-UHFFFAOYSA-N |
| SMILES | FC1(CC(N)C1)F.Cl |
| FDA UNII | PK34LS7DP2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2922390090 | |||||||||
| NFPA 704 |
|
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5597 | 3,3-Difluorocyclobutanamine Hydrochloride | 637031-93-7 | 200MG | $33 | 2026-04-30 | Buy |
| TCI Chemical | D5597 | 3,3-Difluorocyclobutanamine Hydrochloride | 637031-93-7 | 1G | $99 | 2026-04-30 | Buy |
| TRC | TRC-D445980-5G | 3,3-Difluorocyclobutanamine Hydrochloride | 637031-93-7 | 5g | $167 | 2026-06-03 | Buy |
| TRC | TRC-D445980-1G | 3,3-Difluorocyclobutanamine Hydrochloride | 637031-93-7 | 1g | $65 | 2026-06-03 | Buy |
| Apolloscientific | PC405003 | 3,3-Difluorocyclobutanamine hydrochloride 97% | 637031-93-7 | 1g | $21 | 2026-06-04 | Buy |
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
3,3-Difluorocyclobutanamine hydrochloride is used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors.
Uses
3-Halo substituted cyclobutanamine used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors.
Synthesis
939399-53-8
637031-93-7
Step C: Synthesis of 3,3-difluorocyclobutylamine hydrochloride. A mixture of benzyl (3,3-difluorocyclobutyl)carbamate (1.47 g, 6.1 mmol) and 10% Pd/C (1 g) in methanol (20 mL) was subjected to a hydrogen atmosphere (1 atm) and stirred overnight at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol. Concentrated hydrochloric acid (2 mL) was added to the filtrate, followed by evaporation of the solvent under vacuum to afford the target product 3,3-difluorocyclobutanamine hydrochloride (0.8 g, 85% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.60 (m, 3H), 3.64 (m, 1H), 2.89 (m, 4H).
References
[1] Patent: WO2012/9678, 2012, A1. Location in patent: Page/Page column 210
[2] Patent: US2013/303524, 2013, A1. Location in patent: Paragraph 0413-0414
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8898 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15058 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9037 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
View Lastest Price from 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-07 | 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
637031-93-7
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 3,3-difluorocyclobutanamine hydrochloride （Ivosidenib Intermediate）
637031-93-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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2024-04-12 | 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
637031-93-7
|
1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
-
- 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
637031-93-7
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3,3-difluorocyclobutanamine hydrochloride （Ivosidenib Intermediate）
637031-93-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
637031-93-7
- $0.00
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
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