ChemicalBook >> CAS DataBase List >>4-Methyl-2-oxovaleric acid
4-Methyl-2-oxovaleric acid
- CAS No.
- 816-66-0
- Chemical Name:
- 4-Methyl-2-oxovaleric acid
- Synonyms
- KETOLEUCINE;4-METHYL-2-OXOPENTANOIC ACID;ALPHA KETOISOCAPROATE;ALPHA-KETOISOCAPROIC ACID;2-keto-isocaproate;2-OXOISOCAPROIC ACID;2-Oxo-4-methylpentanoic acid;ALPHA-KETOLEUCINE;Methyl-2-oxovaleric;Isopropylpyruvicacid
- CBNumber:
- CB5157543
- Molecular Formula:
- C6H10O3
- Molecular Weight:
- 130.14
- MDL Number:
- MFCD00066204
- MOL File:
- 816-66-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-16 07:06:08
| Melting point | 8-10 °C |
|---|---|
| Boiling point | 82-83 °C11 mm Hg(lit.) |
| Density | 1.055 g/mL at 20 °C(lit.) |
| refractive index |
n |
| FEMA | 3871 | 4-METHYL-2-OXOPENTANOIC ACID |
| FLAVIS Number | 08.052 | 4-Methyl-2-oxovaleric acid |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml |
| pka | 2.65±0.54(Predicted) |
| form | clear liquid |
| color | Colorless to Yellow |
| Odor | fruity |
| Odor Type | fruity |
| Water Solubility | Soluble in water. |
| JECFA Number | 633 |
| BRN | 1701823 |
| InChI | 1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9) |
| InChIKey | BKAJNAXTPSGJCU-UHFFFAOYSA-N |
| SMILES | CC(C)CC(=O)C(O)=O |
| LogP | 0.17 |
| CAS DataBase Reference | 816-66-0(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 4-METHYL-2-OXOPENTANOIC ACID |
| FDA UNII | 4GUJ8AH400 |
| NIST Chemistry Reference | 4-Methyl-2-oxovaleric acid(816-66-0) |
| EPA Substance Registry System | .alpha.-Ketoisocaproic acid (816-66-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-9-13 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2918.30.9000 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| NFPA 704 |
|
4-Methyl-2-oxovaleric acid price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 68255 | 4-Methyl-2-oxovaleric acid ≥98.0% (T) | 816-66-0 | 1g | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | 68255 | 4-Methyl-2-oxovaleric acid ≥98.0% (T) | 816-66-0 | 5g | $299 | 2026-04-30 | Buy |
| TCI Chemical | K0025 | 4-Methyl-2-oxovaleric Acid >95.0%(GC)(T) | 816-66-0 | 5g | $215 | 2026-04-30 | Buy |
| Cayman Chemical | 34749 | α-Ketoisocaproic Acid ≥95% | 816-66-0 | 1g | $62 | 2026-04-30 | Buy |
| Biosynth | FK152625 | α-Ketoisocaproicacid | 816-66-0 | 1000mg | $180 | 2026-06-04 | Buy |
4-Methyl-2-oxovaleric acid Chemical Properties,Uses,Production
Occurrence
Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese.
Uses
4-Methyl-2-oxovaleric acid is an intermediate in the metabolism of leucine and also used as flavoring agents.
Definition
ChEBI: A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
in vivo
4-Methyl-2-oxopentanoic acid (4 mol/L; ICV; 1 h and 15 d) causes impairment of habitual memory and long-term memory in rats[3]. 4-Methyl-2-oxopentanoic acid (400 μmol/kg/h; carotid arch injection; single dose injection 60 min) increases porcine skeletal muscle protein synthesis and plasma leucine levels[4].
| Animal Model: | Thirty-day-old rats were anesthetized with a mixture of ketamine and xylazine (HY-B0443)[3] |
| Dosage: | 4 mol/L, Administer 2 μL |
| Administration: | Intracerebroventricular injection (ICV); 1 h and 15 days |
| Result: | Increased TBARS levels, protein carbonyl content and DNA damage in the hippocampus, striatum and cerebral cortex. SOD activity in the hippocampus and striatum increased 1 hour after injection, and SOD activity in the striatum decreased 15 days later. |
| Animal Model: | Piglets were deprived of feed for 12-14 hours before infusion[4] |
| Dosage: | 400 μmol/kg |
| Administration: | Inject into the aortic arch; the initial injection dose is 148 μmol/kg in the first 10 minutes, and the continuous infusion dose is 400 μmol/kg |
| Result: | Increased phosphorylation of eukaryotic initiation factor (eIF) 4E binding protein-1 (4E-BP1) and eIF4G in skeletal muscle and increased the formation of active eIF4G×eIF4E complexes. |
IC 50
Human Endogenous Metabolite
4-Methyl-2-oxovaleric acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methyl-2-oxovaleric acid Suppliers
Global( 197)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9985 | 58 |
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 823 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
View Lastest Price from 4-Methyl-2-oxovaleric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 4-Methyl-2-oxopentanoic acid
816-66-0
|
$53.00-113.00 | 99.09% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-20 | 4-Methyl-2-oxovaleric acid
816-66-0
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co | |
 |
2019-11-19 | 4-Methyl-2-oxovaleric acid
816-66-0
|
1g | 95%min | 20kf/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 4-Methyl-2-oxopentanoic acid
816-66-0
- $53.00-113.00
- 99.09%
- TargetMol Chemicals Inc.
-
- 4-Methyl-2-oxovaleric acid
816-66-0
- $1.00
- 99%
- Career Henan Chemical Co
-
- 4-Methyl-2-oxovaleric acid
816-66-0
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
816-66-0(4-Methyl-2-oxovaleric acid)Related Search:
1of4
ALPHA-KETOISOCAPROIC ACID
4-METHYL-2-OXOVALERIC ACID
4-Methyl-2-oxovaleric acid >=98.0% (T)
Methyl-2-oxovaleric
2-KETO-ISO-CAPROIC ACID
2-keto-isocaproate
4-methyl-2-oxo-pentanoicaci
Isopropylpyruvicacid
Pentanoic acid, 4-methyl-2-oxo-
4-METHYL-2-OXOVALERIC ACID 95+%
ALPHA-KETOLEUCINE
2-Oxoisocaproic acid, 4-Methyl-2-oxopentanoic acid, Ketoleucine
2-Oxo-4-methylpentanoic acid
KETOISOCAPROIC ACID, ALPHA-(P)
2-Keto-4-methylpentanoic Acid
4-Methyl-2-oxopentanoic Acid
2-KETO-ISO-HEXANOIC ACID
2-KETO-4-METHYL-N-PENTANOIC ACID
2-KETO-4-METHYLPENTANOIC ACID
2-OXO-4-METHYLVALERIC ACID
2-OXOISOCAPROIC ACID
A-KETOISOCAPROIC ACID
4-Methyl-2-oxovalericAcid>
4-Methyl-2-oxovaleric acid -98%
α-Ketoisocaproic Acid
KETOISOCAPROIC ACID, ALPHA-
ethyl-2-oxovaleric acid
4-Methyl-2-oxopentanoic acid, 10 mM in DMSO
4-Methyl-2-oxopentanoic acid (Standard)
4-METHYL-2-OXOPENTANOIC ACID
ALPHA KETOISOCAPROATE
KETOLEUCINE
α-Ketoleucine/α-Ketoleucine
816-66-0
CH32CHCH2COCOOH
Organic Building Blocks
Building Blocks
Carbonyl Compounds
Carboxylic Acids
C6
