Boc-3-(2-Naphthyl)-D-alanine
- CAS No.
- 76985-10-9
- Chemical Name:
- Boc-3-(2-Naphthyl)-D-alanine
- Synonyms
- BOC-D-2-NAL-OH;BOC-L-2-NAL-OH;BOC-D-2-NAPHTHYLALANINE;BOC-L-2-NAPHTHYLALANINE;N-(tert-Butoxycarbonyl)-3-(2-naphthyl)-D-alanine;BOC-2-NAL-OH;BOC-NAL(2)-OH;Boc-2-D-Nal-OH;BOC-D-NAL(2)-OH;BOC-ALA(2-NAPH)-OH
- CBNumber:
- CB5160608
- Molecular Formula:
- C18H21NO4
- Molecular Weight:
- 315.37
- MDL Number:
- MFCD00076900
- MOL File:
- 76985-10-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 92-95 °C(lit.) |
|---|---|
| alpha | -45 º (c=1% in ethanol) |
| Boiling point | 454.92°C (rough estimate) |
| Density | 1.2164 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Sparingly), Ethanol (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 3.88±0.30(Predicted) |
| color | White |
| optical activity | [α]20/D 45±2°, c = 1% in ethanol |
| BRN | 4200660 |
| Major Application | peptide synthesis |
| InChI | 1S/C18H21NO4/c1-18(2,3)23-17(22)19-15(16(20)21)11-12-8-9-13-6-4-5-7-14(13)10-12/h4-10,15H,11H2,1-3H3,(H,19,22)(H,20,21)/t15-/m1/s1 |
| InChIKey | URKWHOVNPHQQTM-OAHLLOKOSA-N |
| SMILES | CC(C)(C)OC(=O)N[C@H](Cc1ccc2ccccc2c1)C(O)=O |
| CAS DataBase Reference | 76985-10-9(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Boc-3-(2-Naphthyl)-D-alanine price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15478 | Boc-D-2-Nal-OH ≥97.0% (HPLC) | 76985-10-9 | 1g | $105 | 2023-01-07 | Buy |
| TCI Chemical | B3616 | N-(tert-Butoxycarbonyl)-3-(2-naphthyl)-D-alanine >98.0%(HPLC)(T) | 76985-10-9 | 1g | $55 | 2026-04-30 | Buy |
| TCI Chemical | B3616 | N-(tert-Butoxycarbonyl)-3-(2-naphthyl)-D-alanine >98.0%(HPLC)(T) | 76985-10-9 | 5g | $213 | 2026-04-30 | Buy |
| Usbiological | 264711 | Boc-3-(2-naphthyl)-D-alanine Asreported | 76985-10-9 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 264711 | Boc-3-(2-naphthyl)-D-alanine Asreported | 76985-10-9 | 5g | $549 | 2026-06-03 | Buy |
Boc-3-(2-Naphthyl)-D-alanine Chemical Properties, Uses, Production
Chemical Properties
off-white granular powder
Uses
Boc-3-(2-Naphthyl)-D-alanine is a reagent in Lanreotide trisulfide synthesis and somatostatin receptor binding activity. Reagent in the preparation by coupling and structure-activity relationships of arginine containing tripeptides as MC4 receptor ligands.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
6960-34-5
74651-77-7
56583-58-5
1. N-tert-butoxycarbonyl-L-3-(2-naphthyl)alanine (0.43 g, 2.0 mmol) was dissolved in a solvent mixture of dioxane (8 ml), water (8 ml) and triethylamine (4 ml). 2. BOC-ON (0.49 g, 2.0 mmol) was added and the reaction mixture was stirred overnight at room temperature under argon protection. 3. After completion of the reaction, water (30 ml) was added for dilution and extracted with ethyl acetate (3 x 20 ml). 4. The aqueous layer was adjusted to pH=4 with 10% citric acid solution and extracted again with ethyl acetate (3 x 20 ml). 5. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a colorless oily product (0.52 g, 82% yield). 6. The product was analyzed by 1H NMR. 6. The product was characterized by 1H NMR (DMSO-d6): δ 7.8 (3H, m), 7.7 (1H, s), 7.4 (3H, m), 7.15 (1H, d), 4.2 (1H, m), 3.2 (1H, m), 2.9 (1H, m), 1.3 (9H, s).
References
[1] Patent: US5486597, 1996, A
Boc-3-(2-Naphthyl)-D-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai HC Biotech Co., Ltd | 021-20227858 | sale@hcbiotech.com.cn | China | 1173 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Suzhou haiyu Biochem Industrial Co., LTD | 512-68097639 18013585858 | 744942877@qq.com | China | 915 | 62 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from Boc-3-(2-Naphthyl)-D-alanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Boc-d-2-nal-oh
76985-10-9
|
1kg | 98% | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-04-20 | Boc-D-2-Nal-OH
76985-10-9
|
$39.00-55.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2019-07-06 | Boc-3-(2-Naphthyl)-D-alanine
76985-10-9
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- Boc-d-2-nal-oh
76985-10-9
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-D-2-Nal-OH
76985-10-9
- $39.00-55.00
- TargetMol Chemicals Inc.
-
- Boc-3-(2-Naphthyl)-D-alanine
76985-10-9
- $1.00
- 99%
- Career Henan Chemical Co
