Isopropyl 3-aminocrotonate
- CAS No.
- 14205-46-0
- Chemical Name:
- Isopropyl 3-aminocrotonate
- Synonyms
- 3-AIE;Nitrendipine Impurity J;Isopropyl aminocrotonate;Nitrendipine Impurity 10;Isopropy1-3-aminocrotomate;ISOPROPYL 3-AMINOCROTONATE;Intermediate Of Nimodipine;Isopropyl b-aminocrotonate;isopropylbeta-aminocrotonate;Isopropyl3-amino-2-butenoate
- CBNumber:
- CB5194645
- Molecular Formula:
- C7H13NO2
- Molecular Weight:
- 143.18
- MDL Number:
- MFCD00134272
- MOL File:
- 14205-46-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 19-23°C |
|---|---|
| Boiling point | 80°C/1mmHg(lit.) |
| Density | 0.987±0.06 g/cm3(Predicted) |
| refractive index | 1.4870 to 1.4910 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform, Ethyl Acetate, Methanol |
| form | Colourless Liquid |
| pka | 5.36±0.70(Predicted) |
| color | Colorless to Light yellow |
| InChI | InChI=1S/C7H13NO2/c1-5(2)10-7(9)4-6(3)8/h4-5H,8H2,1-3H3 |
| InChIKey | YCKAGGHNUHZKCL-UHFFFAOYSA-N |
| SMILES | C(OC(C)C)(=O)C=C(N)C |
| CAS DataBase Reference | 14205-46-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H227 |
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 |
| RTECS | EM9095000 |
| HazardClass | IRRITANT |
| HS Code | 2922498590 |
| REACH Registrations | Active |
Isopropyl 3-aminocrotonate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | I0884 | Isopropyl 3-Aminocrotonate >98.0%(GC)(T) | 14205-46-0 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | I0884 | Isopropyl 3-Aminocrotonate >98.0%(GC)(T) | 14205-46-0 | 5g | $65 | 2026-04-30 | Buy |
| TRC | TRC-I824030-2G | Isopropyl 3-Aminocrotonate | 14205-46-0 | 2g | $123 | 2026-06-03 | Buy |
| TRC | TRC-I824030-250MG | Isopropyl 3-Aminocrotonate | 14205-46-0 | 250mg | $59 | 2026-06-03 | Buy |
| TRC | TRC-I824030-1G | Isopropyl 3-Aminocrotonate | 14205-46-0 | 1g | $65 | 2026-06-03 | Buy |
Isopropyl 3-aminocrotonate Chemical Properties,Uses,Production
Chemical Properties
Colourless Liquid
Uses
Isopropyl 3-Aminocrotonate (cas# 14205-46-0) is a compound useful in organic synthesis.
Hazard
Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and eye irritant.
Synthesis
542-08-5
14205-46-0
The general procedure for the synthesis of isopropyl 3-amino-2-butenoate from isopropyl acetoacetate was as follows: 2.0 g (~20.83 mmol) of isopropyl acetoacetate was accurately weighed and dissolved in 15 mL of anhydrous ethanol. Subsequently, 1.6 g of ammonium acetate was added and the reaction mixture was heated to reflux at 90°C in an oil bath. The reaction progress was monitored by thin layer chromatography (TLC). After 24 hours of reaction, the heating was stopped and the reaction mixture was evaporated to dryness at low temperature. Finally, the reaction solution was distilled under reduced pressure to afford the target compound isopropyl 3-amino-2-butenoate (compound Sf) in 100% yield.
References
[1] Patent: CN102464608, 2016, B. Location in patent: Paragraph 0153; 0154
[2] Patent: CN108101798, 2018, A. Location in patent: Paragraph 0022; 0024; 0026; 0028; 0030-0032; 0034; 0036
[3] Patent: CN105461691, 2016, A. Location in patent: Paragraph 0016
[4] Chemical and Pharmaceutical Bulletin, 1979, vol. 27, # 6, p. 1426 - 1440
[5] Chemical and Pharmaceutical Bulletin, 1989, vol. 37, # 8, p. 2117 - 2121
Isopropyl 3-aminocrotonate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chengyu Biotechnology Co., Ltd. | 021-51525055 | 309639130@qq.com | China | 42 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from Isopropyl 3-aminocrotonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Isopropyl 3-aminocrotonate
14205-46-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | Isopropyl 3-aminocrotonate
14205-46-0
|
$1.00 | 1KG | 98% | 20KG | Career Henan Chemical Co |
-
- Isopropyl 3-aminocrotonate
14205-46-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Isopropyl 3-aminocrotonate
14205-46-0
- $1.00
- 98%
- Career Henan Chemical Co
