Cholic acid methyl ester
- CAS No.
- 1448-36-8
- Chemical Name:
- Cholic acid methyl ester
- Synonyms
- METHYL CHOLATE;NSC 126794;Methyl cholatesee;Cholic acid methyl;Methyl Cholate >Methyl cholate, 98+%;Methyl Cholate, ≥ 97.0%;Cholic Αcid Μethyl Εster;Cholic acid methyl ester;Methyl Cholate See C432610
- CBNumber:
- CB5208377
- Molecular Formula:
- C25H42O5
- Molecular Weight:
- 422.6
- MDL Number:
- MFCD00064934
- MOL File:
- 1448-36-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155-156°C |
|---|---|
| Boiling point | 541.6±50.0 °C(Predicted) |
| Density | 1.141±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14+-.0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | Insoluble in water. Soluble in medium polarity organic solvents. |
| Merck | 14,2203 |
| BRN | 2226989 |
| CAS DataBase Reference | 1448-36-8(CAS DataBase Reference) |
| FDA UNII | E1P59HQX4Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Cholic acid methyl ester price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | M3397-10 | Methyl Cholate | 1g | $403 | 2026-06-03 | Buy | |
| Usbiological | 270487 | Cholic acid methyl ester Asreported | 500mg | $333 | 2026-06-03 | Buy | |
| Usbiological | 270487 | Cholic acid methyl ester Asreported | 1g | $468 | 2026-06-03 | Buy | |
| Usbiological | 270487 | Cholic acid methyl ester Asreported | 2g | $628 | 2026-06-03 | Buy | |
| Usbiological | 270487 | Cholic acid methyl ester Asreported | 5g | $842 | 2026-06-03 | Buy |
Cholic acid methyl ester Chemical Properties, Uses, Production
Chemical Properties
Off-White Solid
Uses
A bile acid derivative as anti-inflammatory and antitumor agent.
Uses
Protected Cholic Acid
Uses
Methyl cholate, is used as a bile acid derivative as anti-inflammatory and antitumor agent.
Definition
ChEBI: Cholic Acid Methyl Ester is a bile acid.
Synthesis
67-56-1
81-25-4
1448-36-8
To a mixed toluene/methanol (30 ml, V/V=2:1) solution of cholic acid (2.0 g, 4.9 mmol) was added trimethylsilyl diazomethane (3.67 ml, 7.34 mmol), and the reaction was stirred for 2 h at 20 °C. The reaction was monitored by thin layer chromatography (TLC, spreader ratio of methanol/dichloromethane=1:10). The progress of the reaction was monitored by thin layer chromatography (TLC, spreading agent ratio methanol/dichloromethane=1:10) to confirm complete consumption of cholic acid and generation of new spots. Upon completion of the reaction, the reaction mixture was concentrated to afford (R)-methyl 4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthracen-17-yl)pentanoate (2.08 g, 100% yield) as a white foamy solid. Its hydrogen NMR spectrum (400MHz, CDCl3) data were as follows: δ 3.98(m, 1H, C12-H), 3.85(m, 1H, C7-H), 3.45(m, 1H, C3-H), 3.66(s, 3H, OCH3), 0.98(d, 3H, 21-Me), 0.89(s, 3H, 19-Me), 0.69 (s, 3H, 18-Me).
References
[1] Drug Metabolism and Disposition, 2017, vol. 45, # 7, p. 721 - 733
[2] Patent: WO2009/146218, 2009, A2. Location in patent: Page/Page column 141
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 93 - 95
[4] Steroids, 2010, vol. 75, # 10, p. 701 - 709
[5] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7128 - 7131
Cholic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
View Latest Price from Cholic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Methyl Cholate
1448-36-8
|
$29.00 | 96.22% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | CHOLIC ACID METHYL ESTER
1448-36-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-24 | CHOLIC ACID METHYL ESTER
1448-36-8
|
$6.60 | 500g | 98% | 500G ,1KG , 100KG | Career Henan Chemical Co |
-
- Methyl Cholate
1448-36-8
- $29.00
- 96.22%
- TargetMol Chemicals Inc.
-
- CHOLIC ACID METHYL ESTER
1448-36-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- CHOLIC ACID METHYL ESTER
1448-36-8
- $6.60
- 98%
- Career Henan Chemical Co
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