| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
- Methyl Cholate
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- $29.00
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2026-05-11
- CAS:1448-36-8
- Purity: 96.22%
- Supply Ability: 10g
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| | Cholic acid methyl ester Basic information |
| Product Name: | Cholic acid methyl ester | | Synonyms: | 5(BETA)-CHOLAMIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL METHYL ESTER;5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL METHYL ESTER;METHYL 4-(3,7,12-TRIHYDROXY-10,13-DIMETHYLPERHYDROCYCLOPENTA[A]PHENANTHREN-17-YL)PENTANOATE;METHYL CHOLATE;Methyl 4-(3,7,12-trihydroxy-10,13-dimethylperhydrocyclopenta[a]phenanthren-17-yl)pen;CHOLIC ACID METHYL ESTER(P);Methyl cholate, 98+%;3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid methyl ester | | CAS: | 1448-36-8 | | MF: | C25H42O5 | | MW: | 422.6 | | EINECS: | 215-903-7 | | Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroids & Hormones - 13C & 2H | | Mol File: | 1448-36-8.mol |  |
| | Cholic acid methyl ester Chemical Properties |
| Melting point | 155-156°C | | Boiling point | 541.6±50.0 °C(Predicted) | | density | 1.141±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Solid | | pka | 14+-.0.70(Predicted) | | color | White to Off-White | | Water Solubility | Insoluble in water. Soluble in medium polarity organic solvents. | | Merck | 14,2203 | | BRN | 2226989 | | CAS DataBase Reference | 1448-36-8(CAS DataBase Reference) |
| Provider | Language |
|
ALFA
| English |
| | Cholic acid methyl ester Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | A bile acid derivative as anti-inflammatory and antitumor agent. | | Uses | Protected Cholic Acid | | Uses | Methyl cholate, is used as a bile acid derivative as anti-inflammatory and antitumor agent. | | Definition | ChEBI: Cholic Acid Methyl Ester is a bile acid. | | Synthesis | To a mixed toluene/methanol (30 ml, V/V=2:1) solution of cholic acid (2.0 g, 4.9 mmol) was added trimethylsilyl diazomethane (3.67 ml, 7.34 mmol), and the reaction was stirred for 2 h at 20 °C. The reaction was monitored by thin layer chromatography (TLC, spreader ratio of methanol/dichloromethane=1:10). The progress of the reaction was monitored by thin layer chromatography (TLC, spreading agent ratio methanol/dichloromethane=1:10) to confirm complete consumption of cholic acid and generation of new spots. Upon completion of the reaction, the reaction mixture was concentrated to afford (R)-methyl 4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthracen-17-yl)pentanoate (2.08 g, 100% yield) as a white foamy solid. Its hydrogen NMR spectrum (400MHz, CDCl3) data were as follows: δ 3.98(m, 1H, C12-H), 3.85(m, 1H, C7-H), 3.45(m, 1H, C3-H), 3.66(s, 3H, OCH3), 0.98(d, 3H, 21-Me), 0.89(s, 3H, 19-Me), 0.69 (s, 3H, 18-Me). | | References | [1] Drug Metabolism and Disposition, 2017, vol. 45, # 7, p. 721 - 733
[2] Patent: WO2009/146218, 2009, A2. Location in patent: Page/Page column 141
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 93 - 95
[4] Steroids, 2010, vol. 75, # 10, p. 701 - 709
[5] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7128 - 7131 |
| | Cholic acid methyl ester Preparation Products And Raw materials |
| Raw materials | Methanol-->Cholic acid-->Toluene-->(TRIMETHYLSILYL)DIAZOMETHANE | | Preparation Products | Ursodeoxycholic acid-->Cholan-24-oic acid, 7,12-dihydroxy-3-[[(4-methylphenyl)sulfonyl]oxy]-, methyl ester, (3α,5β,7α,12α)--->3,7-diketo, 12-hydroxy methyl ester of Cholic Acid-->(5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid-->(3β,5β,7α,12α)-3-(ForMyloxy)-7,12-dihydroxycholan-24-oic Acid Methyl Ester |
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