3-(Trifluoromethyl)phenylhydrazine hydrochloride
- CAS No.
- 3107-33-3
- Chemical Name:
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride
- Synonyms
- 3-Trifloromethylphenylhydrazine;3-TRIFLUOROMETHYL PHENYLHYDRAZINE HCL;3-Hydrazinobenzotrifluoride hydrochloride;3-Trifluoromethylphenylhydrazine hydrochlroide;3-(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE;3-(Triflnoromethyl)phenl hydrazine hydrochloride;N'-(3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINIUM, CHLORIDE;3-(Trifluoromethyl)phenylhydrazine hydrochloride,98%;3107-33-3 3-(Trifluoromethyl)phenylhydrazine hydrochloride;Hydrazine, [3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)
- CBNumber:
- CB5236640
- Molecular Formula:
- C7H8ClF3N2
- Molecular Weight:
- 212.6
- MDL Number:
- MFCD00100503
- MOL File:
- 3107-33-3.mol
- MSDS File:
- SDS
| Melting point | 224-225 °C (decomp) |
|---|---|
| Boiling point | 140℃/30mm |
| Density | 1.348 |
| refractive index | 1.504 (20/D) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO, Methanol |
| form | Solid |
| color | Pale Yellow |
| Specific Gravity | 1.348 |
| CAS DataBase Reference | 3107-33-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280h-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36/37-24/25 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | N | |||||||||
| HS Code | 29280000 | |||||||||
| NFPA 704 |
|
3-(Trifluoromethyl)phenylhydrazine hydrochloride price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 290864 | 3-Trifluoromethyl phenylhydrazine HCl Asreported | 3107-33-3 | 5g | $369 | 2026-06-03 | Buy |
| Usbiological | 290864 | 3-Trifluoromethyl phenylhydrazine HCl Asreported | 3107-33-3 | 10g | $513 | 2026-06-03 | Buy |
| Usbiological | 290864 | 3-Trifluoromethyl phenylhydrazine HCl Asreported | 3107-33-3 | 25g | $701 | 2026-06-03 | Buy |
| Usbiological | 290864 | 3-Trifluoromethyl phenylhydrazine HCl Asreported | 3107-33-3 | 50g | $957 | 2026-06-03 | Buy |
| Usbiological | 290864 | 3-Trifluoromethyl phenylhydrazine HCl Asreported | 3107-33-3 | 100g | $1327 | 2026-06-03 | Buy |
3-(Trifluoromethyl)phenylhydrazine hydrochloride Chemical Properties, Uses, Production
Chemical Properties
Off-white powder
Uses
3-Trifluoromethylphenylhydrazine Hydrochloride, is an intermediate in the synthesis of pharmaceutical compounds including inhibitors, and anticancer agents. It is used in the synthesis of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents.
Synthesis
401-78-5
3107-33-3
General procedure for the synthesis of 3-trifluoromethylphenylhydrazine hydrochloride from m-bromobenzotrifluoride: CuBr (36 mg, 0.25 mmol, 2.5 mol%), ligand L3 (110 mg, 0.4 mmol, 4 mol%), H2O (0.5 mL), and K3PO4 (254 mg, 1.2 mmol) were added and mixed in a 15 mL screw-top capped test tube. STAC (110 mg, 0.3 mmol, 3 mol%) and m-bromobenzotrifluoride (10 mmol) were then added, and the resulting mixture was stirred at 80-110°C (oil bath temperature) for 10 min. Next, K3PO4 (2.29 g, 10.8 mmol) and N2H4-H2O (1 g, 20 mmol) were added and argon gas (flow rate 5-7 mL/min) was bubbled through the reaction mixture for 5 min. The reaction mixture was stirred in a closed test tube at 80-110°C (oil bath temperature) for 1-2 h. The progress of the reaction was monitored by TLC (eluent: hexane) until the feedstock was completely consumed. After completion of the reaction, it was cooled to room temperature and diluted with dichloromethane (50 mL). The resulting solution was filtered and washed with saturated saline (225 mL). A 37% aqueous HCl solution was added dropwise to the dichloromethane solution until the pH reached 3-4. The precipitate formed was filtered, washed with dichloromethane (15 mL) and dried at room temperature. NMR spectra of the partially synthesized 3-trifluoromethylphenylhydrazine hydrochloride showed the presence of 1-5 mol% of the corresponding aniline hydrochloride as an impurity (see Supplementary Data). To obtain an analytically pure sample, it can be purified by precipitation by adding 2-3 volumes of diethyl ether from a methanol solution.
References
[1] Chinese Journal of Chemistry, 2018, vol. 36, # 11, p. 1003 - 1006
[2] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048
3-(Trifluoromethyl)phenylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 3-(Trifluoromethyl)phenylhydrazine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-11 | 3-(Trifluoromethyl)phenylhydrazine hydrochloride
3107-33-3
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 3-(Trifluoromethyl)phenylhydrazine hydrochloride
3107-33-3
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride
3107-33-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride
3107-33-3
- $7.00
- 99%
- Career Henan Chemical Co
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