SB 203580 (hydrochloride)
- CAS No.
- 869185-85-3
- Chemical Name:
- SB 203580 (hydrochloride)
- Synonyms
- SB203580 HCl;RWJ 64809 HCl;Adezmapimod HCl;RWJ 64809 hydrochloride;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;SB 203580 hydrochloride, p38 MAPK inhibitor;SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE
- CBNumber:
- CB52592405
- Molecular Formula:
- C21H17ClFN3OS
- Molecular Weight:
- 413.9
- MDL Number:
- MFCD01862622
- MOL File:
- 869185-85-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20C |
|---|---|
| solubility | insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO |
| form | Bright yellow solid |
| color | Light yellow to yellow |
| Water Solubility | Soluble to 25 mM in water |
| Stability | Hygroscopic |
| InChI | 1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H |
| InChIKey | WOSGGXINSLMASH-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)[S](=O)C.Cl |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
SB 203580 (hydrochloride) price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559395 | SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells). |
869185-85-3 | 1mg | $190 | 2026-04-30 | Buy |
| Sigma-Aldrich | 559395 | SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells). |
869185-85-3 | 10mg | $396 | 2026-04-30 | Buy |
| Cayman Chemical | 13344 | SB 203580 (hydrochloride) ≥95% | 869185-85-3 | 5mg | $123 | 2026-04-30 | Buy |
| Cayman Chemical | 13344 | SB 203580 (hydrochloride) ≥95% | 869185-85-3 | 10mg | $231 | 2026-04-30 | Buy |
| Cayman Chemical | 13344 | SB 203580 (hydrochloride) ≥95% | 869185-85-3 | 25mg | $543 | 2026-04-30 | Buy |
SB 203580 (hydrochloride) Chemical Properties, Uses, Production
Uses
SB 203580 Hydrochloride is a protein kinase inhibitor.
General Description
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
Biological Activity
sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2].
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
References
[1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96.
SB 203580 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
SB 203580 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9777 | 55 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2961 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from SB 203580 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | SB 203580 hydrochloride
869185-85-3
|
$32.00-48.00 | 98.67% | 10g | TargetMol Chemicals Inc. |
-
- SB 203580 hydrochloride
869185-85-3
- $32.00-48.00
- 98.67%
- TargetMol Chemicals Inc.
