SB242235
- CAS No.
- 193746-75-7
- Chemical Name:
- SB242235
- Synonyms
- CS-668;SB242235;SB242235 ≥95%;SB-242235; SB242235;SB 242235, 10 mM in DMSO;inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK;4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine;4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine;Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
- CBNumber:
- CB12621150
- Molecular Formula:
- C19H20FN5O
- Molecular Weight:
- 353.39
- MDL Number:
- MFCD08690575
- MOL File:
- 193746-75-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| SB 242235 | 474182 | 100mg | $1848 |
| SB242235 >98% | orb180841 | 1000mg | $2395.3 |
| 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine 97% | 132624 | 5g | $3960 |
| 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine | 3254AH | 5g | $5396 |
| 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine 97% | 132624 | 10g | $6480 |
| More product size | |||
SB242235 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 474182 | SB 242235 | 193746-75-7 | 100mg | $1848 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180841 | SB242235 >98% | 193746-75-7 | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Matrix Scientific | 132624 | 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine 97% | 193746-75-7 | 5g | $3960 | 2021-12-16 | Buy |
| AK Scientific | 3254AH | 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine | 193746-75-7 | 5g | $5396 | 2021-12-16 | Buy |
| Matrix Scientific | 132624 | 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine 97% | 193746-75-7 | 10g | $6480 | 2021-12-16 | Buy |
SB242235 Chemical Properties,Uses,Production
Uses
SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0 μM in primary human chondrocytes[1].
Biological Activity
SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.
in vitro
SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.
Western Blot Analysis
| Cell Line: | Human chondrocytes |
| Concentration: | 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM |
| Incubation Time: | < td class="col2"> 15 minutes|
| Result: | Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM. |
in vivo
SB242235 (100 mg/kg; p.o.) abolishes MAP-KAPK-2 activity and HSP27 phosphorylation[2].
SB242235 inhibits expression of the pro-inflammatory cytokines interleukin (IL)-6 and KC (murine IL-8) and COX-2[2].
SB-242235 is demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses in rat and monkey[3].
| Animal Model: | Female SKH-1 hairless mice (4–6 weeks)[2] |
| Dosage: | 100 mg/kg |
| Administration: | Oral administered, 30 minutes prior to ultraviolet B (UVB) irradiation |
| Result: | Abolished MAP-KAPK-2 activity and heat shock protein 27 (HSP27) phosphorylation. |
target
IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)
References
[1] Badger, A.M., et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage, 2000. 8(6): p. 434-43. DOI:10.1053/joca.1999.0319
[2] Kim AL , et al. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol. 2005 Jun;124(6):1318-25. DOI:10.1111/j.0022-202X.2005.23747.x
[3] Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Xenobiotica, 2002. 32(3): p. 221-33. DOI:10.1080/00498250110100720
SB242235 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| SYN|thesis med chem P/L | +86-021-50720296 | service@synkinase.com | China | 266 | 58 |
