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C-(1H-INDOL-5-YL)-METHYLAMINE

C-(1H-INDOL-5-YL)-METHYLAMINE structure

CAS No.: 81881-74-5

Chemical Name:: C-(1H-INDOL-5-YL)-METHYLAMINE

Synonyms: Indole-5-methanamine;INDOLE-5-METHYLAMINE;5-(AMINOMETHYL)INDOLE;5-(aminomethyl)-indol;1H-Indole-5-MethanaMine;((Indol-5-yl)Methyl)aMine;(1H-Indol-5-yl)methylamine;(1H-INDOL-5-YL)METHANAMINE;1-(1H-Indol-5-yl)MethanaMine;C-(1H-INDOL-5-YL)-METHYLAMINE

CBNumber:: CB5271243

Molecular Formula:: C9H10N2

Molecular Weight:: 146.19

MDL Number:: MFCD01719220

MOL File:: 81881-74-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:16:05

Product description	Number	Pack Size	Price
(1H-Indol-5-yl)methylamine Asreported	280808	500mg	$240
(1H-Indol-5-yl)methylamine Asreported	280808	1g	$352
5-(Aminomethyl)indole	002363	250mg	$432
5-(Aminomethyl)indole 98%	AS27498	1g	$47
5-(Aminomethyl)indole 98%	AS27498	5g	$150
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C-(1H-INDOL-5-YL)-METHYLAMINE Properties

Melting point	114-122 °C
Boiling point	335.6±17.0 °C(Predicted)
Density	1.199±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	solid
pka	17.07±0.30(Predicted)
Appearance	Light yellow to brown Solid
InChI	InChI=1S/C9H10N2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-5,11H,6,10H2
InChIKey	UAYYSAPJTRVEQA-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(CN)C=C2)C=C1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	NL4461500
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

C-(1H-INDOL-5-YL)-METHYLAMINE price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	280808	(1H-Indol-5-yl)methylamine Asreported	81881-74-5	500mg	$240	2026-06-03	Buy
Usbiological	280808	(1H-Indol-5-yl)methylamine Asreported	81881-74-5	1g	$352	2026-06-03	Buy
Usbiological	002363	5-(Aminomethyl)indole	81881-74-5	250mg	$432	2026-06-03	Buy
Activate Scientific	AS27498	5-(Aminomethyl)indole 98%	81881-74-5	1g	$47	2026-06-04	Buy
Activate Scientific	AS27498	5-(Aminomethyl)indole 98%	81881-74-5	5g	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
280808	500mg	$240	Buy
280808	1g	$352	Buy
002363	250mg	$432	Buy
AS27498	1g	$47	Buy
AS27498	5g	$150	Buy

C-(1H-INDOL-5-YL)-METHYLAMINE Chemical Properties,Uses,Production

Uses

5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751•

Uses

5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.

Uses

Reactant for preparation of:

HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75
Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
SCIO-469-like compounds for the inhibition of p38 MAP kinase
4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors
Non-covalent thrombin inhibitors

Synthesis

15861-24-2

81881-74-5

The hydrogenation reaction was carried out using Raney Nickel as a catalyst in a methanol solution containing ammonia with 5-cyanoindole as starting material. After completion of the reaction, the reaction solution was concentrated under reduced pressure to give a light yellow solid product, C-(1H-indol-5-yl)-methylamine (5.25 g, quantitative yield).

References

[1] Patent: US2004/204455, 2004, A1. Location in patent: Page/Page column 18
[2] Chemistry - A European Journal, 2016, vol. 22, # 14, p. 4991 - 5002
[3] Patent: US2003/153596, 2003, A1
[4] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 584; 585
[5] Patent: WO2011/76784, 2011, A2. Location in patent: Page/Page column 66

C-(1H-INDOL-5-YL)-METHYLAMINE Preparation Products And Raw materials

Raw materials

Copper(I) Cyanide Ethylenediamine N-Methyl-2-pyrrolidone 5-Bromoindole Sodium cyanide

Lithium Aluminum Hydride 5-Cyanoindole Ammonia Methanol Hydrogen

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Preparation Products

5-Cyanoindole

C-(1H-INDOL-5-YL)-METHYLAMINE Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3587	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5973	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Compound Net Biotechnology Inc.	+8615303909093	sales@compound-net.com	China	2914	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Compound Net Biotechnology Inc.	58

View Lastest Price from C-(1H-INDOL-5-YL)-METHYLAMINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-12	C-(1H-INDOL-5-YL)-METHYLAMINE 81881-74-5	$1.00	1KG	99%	10000KG	Shaanxi Dideu Medichem Co. Ltd
2020-02-26	5-(Aminomethyl)indole 81881-74-5	$1.00	1KG	99%+	100 tons	Shaanxi Dideu Medichem Co. Ltd
2020-02-26	5-(Aminomethyl)indole 81881-74-5	$1.00	1KG	99%+	100 tons	Shaanxi Dideu Medichem Co. Ltd

C-(1H-INDOL-5-YL)-METHYLAMINE
81881-74-5
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

5-(Aminomethyl)indole
81881-74-5
$1.00
99%+
Shaanxi Dideu Medichem Co. Ltd

5-(Aminomethyl)indole
81881-74-5
$1.00
99%+
Shaanxi Dideu Medichem Co. Ltd

C-(1H-INDOL-5-YL)-METHYLAMINE Spectrum

C-(1H-INDOL-5-YL)-METHYLAMINE(81881-74-5)¹HNMR

81881-74-5(C-(1H-INDOL-5-YL)-METHYLAMINE)Related Search:

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5-(aminomethyl)-indol INDOLE-5-METHYLAMINE C-(1H-INDOL-5-YL)-METHYLAMINE (1H-INDOL-5-YL)METHANAMINE (1H-Indol-5-yl)methylamine 5-(AMINOMETHYL)INDOLE ((Indol-5-yl)Methyl)aMine 1-(1H-Indol-5-yl)MethanaMine 1H-Indole-5-MethanaMine Indole-5-methanamine 81881-74-5 Indoles Heterocyclic Building Blocks Building Blocks Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals pharmacetical Building Blocks Heterocyclic Building Blocks Indoles Building Blocks C7 to C9 Chemical Synthesis Heterocyclic Building Blocks