- 5-(Aminomethyl)indole
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- $1.00
-
2020-02-26
- CAS: 81881-74-5
- Min. Order: 1KG
- Purity: 99%+
- Supply Ability: 100 tons
- 5-(Aminomethyl)indole
-
- $1.00
-
2020-02-26
- CAS: 81881-74-5
- Min. Order: 1KG
- Purity: 99%+
- Supply Ability: 100 tons
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| | C-(1H-Indol-5-yl)-methylamine Basic information |
| | C-(1H-Indol-5-yl)-methylamine Chemical Properties |
| Melting point | 114-122 °C | | Boiling point | 335.6±17.0 °C(Predicted) | | density | 1.199±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 17.07±0.30(Predicted) | | Appearance | Light yellow to brown Solid | | InChI | InChI=1S/C9H10N2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-5,11H,6,10H2 | | InChIKey | UAYYSAPJTRVEQA-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(CN)C=C2)C=C1 |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | NL4461500 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | C-(1H-Indol-5-yl)-methylamine Usage And Synthesis |
| Uses | 5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751• | | Uses | 5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors. | | Uses | Reactant for preparation of:
- HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75
- Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
- SCIO-469-like compounds for the inhibition of p38 MAP kinase
- 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors
- Non-covalent thrombin inhibitors
| | Synthesis | The hydrogenation reaction was carried out using Raney Nickel as a catalyst in a methanol solution containing ammonia with 5-cyanoindole as starting material. After completion of the reaction, the reaction solution was concentrated under reduced pressure to give a light yellow solid product, C-(1H-indol-5-yl)-methylamine (5.25 g, quantitative yield). | | References | [1] Patent: US2004/204455, 2004, A1. Location in patent: Page/Page column 18
[2] Chemistry - A European Journal, 2016, vol. 22, # 14, p. 4991 - 5002
[3] Patent: US2003/153596, 2003, A1
[4] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 584; 585
[5] Patent: WO2011/76784, 2011, A2. Location in patent: Page/Page column 66 |
| | C-(1H-Indol-5-yl)-methylamine Preparation Products And Raw materials |
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