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Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Structure
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- structure
CAS No.
330792-69-3
Chemical Name:
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-
Synonyms
2-(Methoxy(4-phenoxyphenyl)Methylene)Malononitrile;Triamide impurity;Zanubrutinib Impurity 5;Zanubrutinib dimer impurity;Zanubrutinib Related Compound 3;1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene;2-(Methoxy(4- phenoxyphenyl)Methylene)Malononitri;1,1-dicyano-2-Methoxy-2-(4-Phenoxyphenyl)Ethylene;Methoxy(4phenoxyphenyl)methyli dene]propanedinitrile;2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile
CBNumber:
CB52716346
Molecular Formula:
C17H12N2O2
Molecular Weight:
276.29
MDL Number:
MFCD20140315
MOL File:
330792-69-3.mol
MSDS File:
SDS
Last updated:2026-05-28 05:17:16
Product description Number Pack Size Price
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% M58895 250mg $62
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% M58895 1g $68
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% M58895 5g $70
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% M58895 25g $240
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% M58895 10g $330
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Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Properties

Boiling point 471.1±45.0 °C(Predicted)
Density 1.199±0.06 g/cm3(Predicted)
storage temp. 2-8°C
Appearance Light yellow to yellow Solid
InChI InChI=1S/C17H12N2O2/c1-20-17(14(11-18)12-19)13-7-9-16(10-8-13)21-15-5-3-2-4-6-15/h2-10H,1H3
InChIKey IRVRZQLHMPWLLY-UHFFFAOYSA-N
SMILES C(#N)/C(=C(/OC)\C1=CC=C(OC2=CC=CC=C2)C=C1)/C#N

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
REACH Registrations Active

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix M58895 2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% 330792-69-3 250mg $62 2026-05-06 Buy
Synthonix M58895 2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% 330792-69-3 1g $68 2026-05-06 Buy
Synthonix M58895 2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% 330792-69-3 5g $70 2026-05-06 Buy
Synthonix M58895 2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% 330792-69-3 25g $240 2026-05-06 Buy
Synthonix M58895 2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile 97% 330792-69-3 10g $330 2026-05-06 Buy
Product number Packaging Price Buy
M58895 250mg $62 Buy
M58895 1g $68 Buy
M58895 5g $70 Buy
M58895 25g $240 Buy
M58895 10g $330 Buy

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Chemical Properties,Uses,Production

Synthesis

4-PHENOXYBENZOYL CHLORIDE

1623-95-6

Dimethyl sulfate

77-78-1

Malononitrile

109-77-3

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-

330792-69-3

6.6 g of malononitrile (0.1 mol), 4.8 g of sodium hydride (0.2 mol, 80% dispersed in paraffin) and 100 mL of freshly treated anhydrous tetrahydrofuran were added to a three-neck flask. Under stirring conditions, 50 mL of tetrahydrofuran solution containing 4-phenoxybenzoyl chloride (23.2 g, 0.1 mol) was slowly added dropwise to the reaction system. After 2 hours of reaction at room temperature, 250 mL of 1 M dilute hydrochloric acid was added and stirring was continued for 30 minutes, followed by three extractions with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated to give a solid. The solid was dissolved in a mixture of 150 mL of dioxane and 50 mL of saturated sodium bicarbonate solution, followed by the addition of dimethyl sulfate (37.8 g, 0.3 mol), and the reaction mixture was heated to 80 °C. The reaction was stirred at 90 °C for 3 h. The completion of the reaction was monitored by TLC. At the end of the reaction, 400 mL of deionized water was added and extracted three times with methyl tert-butyl ether. The organic phases were combined and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was recrystallized from methanol to give 17.6 g of white solid 2-(methoxy(4-phenoxyphenyl)methylene)malononitrile in 63.8% yield.

References

[1] Patent: US2016/264584, 2016, A1. Location in patent: Paragraph 0019

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Preparation Products And Raw materials

Raw materials

4-PHENOXYBENZOYL CHLORIDE Dimethyl sulfate Malononitrile Trimethoxymethane Sodium hydride
Mineral oil 1,4-Dioxane Hydrochloric acid Water Tetrahydrofuran

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Preparation Products

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Suppliers

Global( 131)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14034 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1796 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1314 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 contact@trustwe.com China 5742 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
Linyi Changqing Chemical Co., LTD 		+86-0532-55729510 +86-15853232676 marketing@echemi.com China 287 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 +86-18958018566 info@afinechem.com China 15058 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
career henan chemical co 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Linyi Changqing Chemical Co., LTD 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58

View Lastest Price from Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- pictures 2026-08-17 Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-
330792-69-3
 $3.00-10.00 1kg 99% Henan Fengda Chemical Co., Ltd
2-[methoxy(4-phenoxyphenyl)-methylene]propanedinitrile pictures 2024-11-26 2-[methoxy(4-phenoxyphenyl)-methylene]propanedinitrile
330792-69-3
 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile pictures 2019-07-06 2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile
330792-69-3
 $100.00 1KG 98% 100KG Career Henan Chemical Co

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Spectrum

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-(330792-69-3)1HNMR

330792-69-3(Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-)Related Search:

Vandetanib Vardenafil hydrochloride (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (R)-Zanubrutinib Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)-
tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- 1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim ent-Tadalafil
cis-ent-Tadalafil cis-Tadalafil 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (S)-1-Boc-3-hydroxypiperidine
Chloropretadalafil Trelagliptin succinate Tadalafil

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1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene 2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- 2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile Intermediate of Ibrutinib, Note separate 2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile 2-(Methoxy(4- phenoxyphenyl)Methylene)Malononitri ROPANEDINITRILE, 2-[METHOXY(4-PHENOXYPHENYL)METHYLENE]- Zanubrutinib Related Compound 3 Zanubrutinib Impurity 5 7-(1-(3-(4-(3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Triamide impurity Methoxy(4phenoxyphenyl)methyli dene]propanedinitrile Zanubrutinib dimer impurity 1,1-dicyano-2-Methoxy-2-(4-Phenoxyphenyl)Ethylene 2-(Methoxy(4-phenoxyphenyl)Methylene)Malononitrile 330792-69-3 30792-69-3