Enalapril
- CAS No.
- 75847-73-3
- Chemical Name:
- Enalapril
- Synonyms
- Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR
- CBNumber:
- CB1295108
- Molecular Formula:
- C20H28N2O5
- Molecular Weight:
- 376.45
- MDL Number:
- MFCD00865774
- MOL File:
- 75847-73-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Enalapril ≥98% | 16041 | 1g | $48 |
| Enalapril ≥98% | 16041 | 5g | $165 |
| Enalapril 99.96% | CS-2918 | 50mg | $27 |
| Enalapril 99.96% | CS-2918 | 100mg | $43 |
| Enalapril 99.96% | CS-2918 | 250mg | $87 |
| More product size | |||
| Melting point | 142-147℃ |
|---|---|
| Boiling point | 582.4±50.0 °C(Predicted) |
| Density | 1.204±0.06 g/cm3(Predicted) |
| RTECS | TW3665500 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate) |
| color | White to off-white |
| optical activity | -58.8066°(C=0.7659g/100ml DMF) |
| Water Solubility | Soluble in water at 25mg/ml |
| BCS Class | 3 |
| InChIKey | GBXSMTUPTTWBMN-XIRDDKMYSA-N |
| SMILES | C(O)(=O)[C@@H]1CCCN1C(=O)[C@H](C)N[C@H](C(OCC)=O)CCC1=CC=CC=C1 |
| CAS DataBase Reference | 75847-73-3(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | enalapril |
| FDA UNII | 69PN84IO1A |
| NCI Drug Dictionary | Vasotec |
| ATC code | C09AA02 |
| EPA Substance Registry System | L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H361 |
| Precautionary statements | P280 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | Repr. 2 Skin Sens. 1 |
| Hazardous Substances Data | 75847-73-3(Hazardous Substances Data) |
Enalapril price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16041 | Enalapril ≥98% | 75847-73-3 | 1g | $48 | 2021-12-16 | Buy |
| Cayman Chemical | 16041 | Enalapril ≥98% | 75847-73-3 | 5g | $165 | 2021-12-16 | Buy |
| ChemScene | CS-2918 | Enalapril 99.96% | 75847-73-3 | 50mg | $27 | 2026-06-04 | Buy |
| ChemScene | CS-2918 | Enalapril 99.96% | 75847-73-3 | 100mg | $43 | 2026-06-04 | Buy |
| ChemScene | CS-2918 | Enalapril 99.96% | 75847-73-3 | 250mg | $87 | 2026-06-04 | Buy |
Enalapril Chemical Properties,Uses,Production
Uses
angiotensin converting enzyme inhibitor
Uses
It is used for hypertension and chronic cardiac insufficiency.
Uses
Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.
Definition
ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Mechanism of action
Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.
Synthesis
Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.
in vivo
Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4].
| Animal Model: | Male NMRI mice 20-40 g[4] |
| Dosage: | 0.03 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg. |
Enalapril Preparation Products And Raw materials
Raw materials
1of5
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 | wuzhouding@huihecrop.com | China | 886 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1369 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32466 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15079 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9048 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
View Lastest Price from Enalapril manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | Enalapril
75847-73-3
|
1kg | 99% | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-07-27 | Enalapril
75847-73-3
|
$31.00 | 99.51% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-08-12 | Enalapril
75847-73-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
