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ChemicalBook >> CAS DataBase List >>2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Structure
2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid structure
CAS No.
65872-41-5
Chemical Name:
2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
Synonyms
ATMA;ATMAA;AMAA;Cefepime EP Impurity D;CefepiMe Related CoMpound D;(2-Amino-thiazol-4-yl)-methoxyimino-acetic acid;ATMIA;-4-yL;ATMAA CAS;Ansaxime acid
CBNumber:
CB5294497
Molecular Formula:
C6H7N3O3S
Molecular Weight:
201.2
MDL Number:
MFCD00071528
MOL File:
65872-41-5.mol
MSDS File:
SDS
Last updated:2026-05-28 02:29:41
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2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Properties

Melting point 192 °C (dec.)(lit.)
Boiling point 425.1±37.0 °C(Predicted)
Density 1.463 (estimate)
refractive index 1.6630 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 2.97±0.10(Predicted)
form solid
color White to Off-White
Water Solubility 0.6 g/100 mL (20 ºC)
λmax 273nm(MeOH)(lit.)
InChI InChI=1S/C6H7N3O3S/c1-12-9-4(5(10)11)3-2-13-6(7)8-3/h2H,1H3,(H2,7,8)(H,10,11)/b9-4+
InChIKey NLARCUDOUOQRPB-RUDMXATFSA-N
SMILES C1(=CSC(N)=N1)/C(/C(=O)O)=N\OC
CAS DataBase Reference 65872-41-5(CAS DataBase Reference)
FDA UNII 31Y5PR0Y6R
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-24/25
WGK Germany  3
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 1

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2851 Cefepime Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material 65872-41-5 50MG $665 2026-04-30 Buy
Sigma-Aldrich 280143 2-Amino-α-(methoxyimino)-4-thiazoleacetic acid, predominantly syn 97% 65872-41-5 5g $44 2026-04-30 Buy
Sigma-Aldrich 1097680 2-Amino-α-(methoxyimino)-4-thiazoleacetic acid, predominantly syn 65872-41-5 20mg $1290 2026-04-30 Buy
TCI Chemical A2478 (Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid >98.0%(HPLC)(T) 65872-41-5 5g $31 2026-04-30 Buy
TCI Chemical A2478 (Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid >98.0%(HPLC)(T) 65872-41-5 25g $62 2026-04-30 Buy
Product number Packaging Price Buy
PHR2851 50MG $665 Buy
280143 5g $44 Buy
1097680 20mg $1290 Buy
A2478 5g $31 Buy
A2478 25g $62 Buy

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Chemical Properties, Uses, Production

Chemical Properties

OFF-WHITE TO BEIGE POWDER

Uses

Intermediate in the preparation of Cephem compounds.

Synthesis

Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate

64485-88-7

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

65872-41-5

General procedure for the synthesis of aminothiazole acid from ethyl (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate (Example 2): in a 250 ml reaction vial, 45.9 g (0.2 mol) of ethyl (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate was suspended in 200 ml of ethanol, followed by the addition of 1 N sodium hydroxide aqueous solution. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7.0 with 10% aqueous hydrochloric acid, followed by distillation under reduced pressure to remove the ethanol. The aqueous phase was washed with ethyl acetate and the pH was adjusted again with 10% aqueous hydrochloric acid to 2.8. Stirring was carried out under cooling conditions in an ice bath to induce the precipitation of crystals. The crystals were separated by filtration, washed with acetone and finally recrystallized from ethanol to give 22.9 g of 2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid in 57.0% yield.

References

[1] Patent: EP859002, 1998, A1

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Preparation Products And Raw materials

Raw materials

Thiourea Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate Hydrochloric acid Sodium hydroxide Ethanol

Preparation Products

Cefotaxime sodium (Z)-2-(2-Amino-5-chlorothiazol-4-yl)-2-(methoxyimino)acetic acid 1-[2-(Z)-Methoxyimino-2-(2-aminothiazol-4-yl)acetoxy]benzotrizole

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Suppliers

Global Suppliers ( 422)
Supplier Tel Email Country ProdList Advantage
Hebei Jiacheng Trading Co., LTD 15633119114 348013489@qq.com China 11 58
Wuhan Hongde Yuexin Pharmatech Co.,Ltd 027-83855393 15827063722 3306264753@qq.com China 1000 58
Shijiazhuang Ruitian Biochemical Co. Ltd 15831127780 52714113@qq.com China 2354 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
shanghai science Bio-Pharmceutical.co,ltd. 021-021-57872719 13761402923 245662540@qq.com China 299 60
Supplier Advantage
Hebei Jiacheng Trading Co., LTD 58
Wuhan Hongde Yuexin Pharmatech Co.,Ltd 58
Shijiazhuang Ruitian Biochemical Co. Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
shanghai science Bio-Pharmceutical.co,ltd. 60

View Latest Price from 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid pictures 2026-09-11 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
65872-41-5
 1kg 98%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid pictures 2026-09-02 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
65872-41-5
 $2.00-8.00 1kg 99% Henan Fengda Chemical Co., Ltd
2-(2-Aminothiazole-4-yl)-2-methoxyiminoa pictures 2026-08-08 2-(2-Aminothiazole-4-yl)-2-methoxyiminoa
65872-41-5
 $32.00-72.00 99.83% 10g TargetMol Chemicals Inc.

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Spectrum

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(65872-41-5)1HNMR2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(65872-41-5)IR2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(65872-41-5)Raman

65872-41-5 (2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid) Related Search:

Cefotaxime Ethyl 3-aminopropanoate hydrochloride Cefotaxime sodium Iminodiacetic acid 4-Aminophenylacetic acid
2-(2-Aminothiazol-4-yl)glyoxylic acid Nitrilotriacetic acid 2-Aminothiazole Cefoxitin Impurity 3 Tenofovir Impurity 92
Teprenone 1-Methylpyrrolidine T 2588G CefepiMe interMediate (7-PIME) Cefepime EP Impurity F
Cefepime Impurity A Glycine α-Lipoic Acid

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2-Amino-α-(methoxyimino)-4-thiazoleacetic acid (Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid 2-aminothiazole-methoxyiminoaceticacid 2-Methoxylimino-2-(2-aminothiozol)-4-aceticacid ATMIA 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(ATMMA) (Z)-2-methoxyimino-2-(2-aminothiazol-4-yl)Acetic acid anhydrous 2-(2-AMINO-4-THIAZOL)-2-METHOXIMINOACETIC ACID (Z)-2-(2-Aminothiazol-4-yl)-2- 2-amino-α-(methoxyimino)-4-thiazoleacetic acid, predominantly syn 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic acid (Z)-2-METHOXYIMINO-2-(2-AMINOTHIAZOLE-4-YL-)-ACETIC ACID ANHYDROUS/ATMAA ATMAA CAS ATMIA:2-(2-AMINO-4-THIAZOLYL)-2-METHOXYIMINOACETIC ACID 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid (AMAA) （Z）-2-methoxyimino-2-(2-aminothiazole)-4-acetic acid 2-AMINO-ALPHA-(METHOXYIMINO)-4-THIAZOLE ACETIC ACI (Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic acid 4-THIAZOLEACETICACID,2-AMINO-A-(METHOXYIMINO)- ATIFICIALCOW-BEZOAR (Z)-2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLEACETIC ACID (Z)-2-AMINO-A-(METHOXYIMINO)-4-THIAZOLEACETIC ACIDCEFOTAXIME 2-AMINO-A-(METHOXYIMINO)-4-THIAZOLEACETIC ACID 2-AMINO-A-(METHOXYIMINO)-4-THIAZOLEACETIC ACIDB-LACTAMASE INHIBITOR (z)-2-(2-Aminothiazol-4-yl)-2-methoxyimino acetic acid Anhydrous 2-AMINO-ALPHA-(METHOXYIMINO)-4-THIAZOLE- ACETIC ACID, 97%, PREDOMINANTLY SYN AMAA (Z)-2-(2-Aminothiazol-4-Yl)-2-MethoxyiminoAceticAcidAnhydrous(Atmaa) (Z)-(2-Aminothiazol-4-yl)-a-(methoxyimino)acetic acid (Z)-2-Amino-a-(methoxyimino)-4-thiazoleacetic acid 2-(2-Amino-4-thiazolyl)-(Z)-2-methoxyiminoacetic acid 2-Methoxylimino-2-(2-aminothiazolyl)-4-acetic acid (2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Aminothiaoximinoacid Aminothiaoximoacid 2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETIC ACID 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)- (Z)-2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINO ACETIC ACID (Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYIMINOACETIC ACID (Z)-2-Methoxyimino-2-(2-Amino-Thiazole-4-Yl-)-Acetic Acid Anhydrous 2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid syn-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetic acid syn-Thiazoximic acid 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid ,98% (2-Aminothiazol-4-yl)[(Z)-methoxyimino]acetic acid 2-amino-alpha-(methoxyimino)-4-thiazoleacetate 2-(2-Amino-4-thiazoly)-2-methoxyiminoacetic acid 2-(2-Aminothiazole-4-yl)-2-methoxyiminoaceticacid,97% 2-Amino-alpha-(methoxyimino)-4-thiazoleacetic acid 2-Amino-α-(methoxyimino)-4-thiazoleacetic Acid (z)-(2-aminothiazole-4-yl)-2-methoxyiminoacetic acid (Z)-2-amino-alpha-(methoxyimino)thiazol-4-acetic acid 2-(2-AMinothiazole-4-yl)-2-MethoxyiMinoacetic acid, predoMinantly syn ThiazoxiMic Acid 2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetic acid 2-(2-AMinothiazol-4-yl)-2-(MethoxyiMino)acetic acid (Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetic Acid, 98.0%(LC&T Cefepime Related Compound D (20 mg) ((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetic acid)