Benidipine hydrochloride
- CAS No.
- 91599-74-5
- Chemical Name:
- Benidipine hydrochloride
- Synonyms
- (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1);Conipros;Benidipin;rac-Benidipine HCl;Benidipine hydrochlo;Benidipine Impurity 4;Benidipine hydrochloride;rac Benidipine Hydrochloride;Benidipine hydrochloride USP/EP/BP;Benidipine hydrochloride - Bio-X ?
- CBNumber:
- CB5294563
- Molecular Formula:
- C28H31N3O6.HCl
- Molecular Weight:
- 542.02
- MDL Number:
- MFCD00906929
- MOL File:
- 91599-74-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 199-201°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 7.34(at 25℃) |
| form | powder |
| color | yellow |
| InChIKey | DGVVISBYHUXFIU-UHFFFAOYSA-N |
| SMILES | C(C1=C(NC(=C([C@H]1C1C=CC=C(C=1)N(=O)=O)C(=O)OC)C)C)(=O)O[C@@H]1CCCN(C1)CC1C=CC=CC=1.Cl |
| CAS DataBase Reference | 91599-74-5(CAS DataBase Reference) |
| FDA UNII | 0A6746FWDL |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US7975657 | |||||||||
| HS Code | 2933.99.5300 | |||||||||
| HazardClass | 6.1 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Toxicity | LD50 orally in male mice: 218 mg/kg (Muto, 1988) | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Benidipine hydrochloride price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B6813 | Benidipine hydrochloride ≥98% (HPLC) | 91599-74-5 | 10mg | $85.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | B6813 | Benidipine hydrochloride ≥98% (HPLC) | 91599-74-5 | 50mg | $332 | 2026-04-30 | Buy |
| TCI Chemical | B5629 | Benidipine Hydrochloride | 91599-74-5 | 100MG | $21 | 2026-04-30 | Buy |
| TCI Chemical | B5629 | Benidipine Hydrochloride | 91599-74-5 | 1G | $170 | 2026-04-30 | Buy |
| Cayman Chemical | 21607 | Benidipine (hydrochloride) ≥98% | 91599-74-5 | 10mg | $41 | 2026-04-30 | Buy |
Benidipine hydrochloride Chemical Properties, Uses, Production
Description
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.
Description
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.
Chemical Properties
Yellow Crystalline Powder
Originator
Kyowa Hakko (Japan)
Uses
A dihydropyridine calcium channel blocker. Antihypertensive.
brand name
Coniel
Biological Activity
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
Safety Profile
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.
Synthesis
14813-01-5
74936-72-4
91599-74-5
Under sonication conditions, 10 g of monomethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate was placed in a 200 mL reaction flask, to which 14 mL of N,N-dimethylformamide (DMF) and 56 mL of dichloromethane were added. Under ice bath conditions, 2.4 mL of thionyl chloride was slowly added to the resulting homogeneous suspension, followed by stirring the reaction mixture for 1 hour until a clarified solution was formed. Next, 6.3 g of 1-benzyl-3-piperidinol was added and stirring was continued for 2.5 hours under ice bath conditions. Upon completion of the reaction, the reaction solution was washed with 40 mL of water (repeated 4 times) and 40 mL of saturated brine solution (1 time). The organic phase was dried by adding 4 g of anhydrous sodium sulfate for 2 hours. After drying, the sodium sulfate solid was removed by filtration and the dichloromethane was recovered by distillation under reduced pressure to give the crude yellow to red (R)-rel-3-((R)-1-benzylpiperidin-3-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride. The crude product was dissolved in 100 mL of acetone and sonicated at 150 W and 40 kHz for 7 min, followed by filtration under reduced pressure and drying to give 5.9 g of yellow powdery product in 36.2% yield.
storage
room temperature (desiccate)
References
[1] Patent: WO2012/142815, 2012, A1. Location in patent: Page/Page column 5; 6
Benidipine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Kehui Pharmaceutical Co. LTD | 0531-68651908; 13276409687 | 469553953@qq.com | China | 38 | 58 |
| Shanghai Dongyue Biochem Co.,Ltd. | 021-64109415转822 13512134376 | amyzhang@dybiochem.com | China | 34 | 58 |
| Lanzhou Dawnrays Pharmaceutical Co Ltd | 0931-0931-4910898 19913936884 | sales@dawnrays.com | China | 39 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from Benidipine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-12 | Benidipine hydrochloride
91599-74-5
|
$1050.00 | 100g | 99% | 10kg | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-07-27 | Benidipine hydrochloride
91599-74-5
|
$30.00-92.00 | 99.80% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | Benidipine hydrochloride
91599-74-5
|
1kg | 98% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Benidipine hydrochloride
91599-74-5
- $1050.00
- 99%
- Baoji Guokang Healthchem Co., Ltd.
-
- Benidipine hydrochloride
91599-74-5
- $30.00-92.00
- 99.80%
- TargetMol Chemicals Inc.
-
- Benidipine hydrochloride
91599-74-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
