1-Benzyl-3-piperidinol
- CAS No.
- 14813-01-5
- Chemical Name:
- 1-Benzyl-3-piperidinol
- Synonyms
- N-BENZYL-3-HYDROXYPIPERIDINE;1-BENZYL-3-HYDROXYPIPERIDINE;1-benzyl-3-piperidol;1-Benzyl-3-piperidin;1-Bezyl-3-piperidinol;Benidipine Impurity 8;N-BENZYL-3-PIPERIDINOL;1-BENZYL-3-PIPERIDINOL;1-BENZYL-PIPERIDIN-3-OL;1-Benzoyl-3-piperidinol
- CBNumber:
- CB7718344
- Molecular Formula:
- C12H17NO
- Molecular Weight:
- 191.27
- MDL Number:
- MFCD00023734
- MOL File:
- 14813-01-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 140-142°C 6mm |
|---|---|
| Density | 1,056 g/cm3 |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | clear liquid |
| pka | 14.82±0.20(Predicted) |
| color | Colorless to Light yellow |
| Sensitive | Hygroscopic |
| BRN | 135964 |
| InChI | InChI=1S/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2 |
| InChIKey | UTTCOAGPVHRUFO-UHFFFAOYSA-N |
| SMILES | N1(CC2=CC=CC=C2)CCCC(O)C1 |
| CAS DataBase Reference | 14813-01-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29333990 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1-Benzyl-3-piperidinol price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 653446 | N-Benzyl-3-hydroxypiperidine 97% | 14813-01-5 | 1g | $80.3 | 2023-01-07 | Buy |
| Sigma-Aldrich | 653446 | N-Benzyl-3-hydroxypiperidine 97% | 14813-01-5 | 5g | $288 | 2023-01-07 | Buy |
| TCI Chemical | B4868 | 1-Benzyl-3-hydroxypiperidine >97.0%(GC)(T) | 14813-01-5 | 5g | $89 | 2026-04-30 | Buy |
| TCI Chemical | B4868 | 1-Benzyl-3-hydroxypiperidine >97.0%(GC)(T) | 14813-01-5 | 25g | $267 | 2026-04-30 | Buy |
| AstaTech | 26334 | 1-N-BENZYL-3-HYDROXY-PIPERIDINE 97% | 14813-01-5 | 17G | $17 | 2026-04-30 | Buy |
1-Benzyl-3-piperidinol Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Uses
Reactant for bioresolution of tertiary amino ester protic ionic liquids using subtilisin
Reactant for synthesis of:
- Muscarinic M3 selective antagonists
- Rho kinase inhibitors
- Piperidine derivatives for investigations into α-adrenoreceptor direct activation
Synthesis
40114-49-6
14813-01-5
General procedure for the synthesis of 1-benzyl-3-piperidinol from 1-benzyl-3-piperidone: first, N-benzyl-3-piperidone hydrochloride was converted to a free base by the addition of an aqueous solution of K2CO3, which was subsequently extracted with ethyl acetate. Next, sodium borohydride (NaBH4) (0.438 g, 11.57 mmol) was slowly added to an ethanol solution containing N-benzyl-3-piperidone (2.19 g, 11.57 mmol) over 10 min. The reaction mixture was stirred overnight at room temperature and then concentrated under vacuum. The concentrated residue was dissolved in 1.0 N HCl and washed twice with diethyl ether. Afterwards, the aqueous phase was adjusted to pH 12 with 3.0N KOH and extracted three times with dichloromethane. The organic phases were combined and dried with Na2SO4, followed by vacuum concentration. The purity of the crude product was 100% (1.900 g, 86% yield) by IC/MS (EI) analysis: m/z 192.3 (M+1).
Waste Disposal
2,4-Dichloro-5-methoxypyrimidine is a halogen-containing aromatic ring organic compound, which is more harmful to the water environment. Therefore, undiluted or large amounts of 2,4-dichloro-5-methoxypyrimidine should not be exposed to groundwater, waterways, or sewage systems.
References
[1] Patent: WO2005/26145, 2005, A2. Location in patent: Page/Page column 98
[2] Process Biochemistry, 2017, vol. 56, p. 90 - 97
1-Benzyl-3-piperidinol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianchang city Chunfeng Fine Synthetic Material Plant | 0550-7039583 0550-7552998 13905508100;13905508100 | ycgquan@163.com | China | 16 | 64 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| Changzhou Changjin Pharmaceutical Technology Co., Ltd | 0519-83818068 18951215668 | sales@cjpharmtech.com | China | 124 | 55 |
| Chongqing Ensky Pharmaceutical Co.,Ltd. | 023-86815286 13983794297 | sales@ensky-chemical.com | China | 89 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| Jinan Jiecheng Biotechnology Co., LTD | 18669572301 | 695919949@qq.com | China | 38 | 58 |
| Lanzhou Dawnrays Pharmaceutical Co Ltd | 0931-0931-4910898 19913936884 | sales@dawnrays.com | China | 39 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
View Latest Price from 1-Benzyl-3-piperidinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-30 | 1-Benzyl-3-hydroxypiperide
14813-01-5
|
$15.00-50.00 | 1kg | NLT98% | 5 ton per month | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2026-06-30 | 1-Benzyl-3-piperidinol
14813-01-5
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 1-Benzyl-3-piperidinol
14813-01-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 1-Benzyl-3-hydroxypiperide
14813-01-5
- $15.00-50.00
- NLT98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- 1-Benzyl-3-piperidinol
14813-01-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Benzyl-3-piperidinol
14813-01-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
