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Benidipine

Benidipine Structure
Benidipine structure
CAS No.
105979-17-7
Chemical Name:
Benidipine
Synonyms
BENIDIPINE HCL;(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;KW-3049;5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;CONIEL;BENIDIPINE;NACADIPINE;CAPADIPINE;Benidipene
CBNumber:
CB2131201
Molecular Formula:
C28H31N3O6
Molecular Weight:
505.56
MDL Number:
MFCD00906929
MOL File:
105979-17-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-21 10:31:43
Product description Number Pack Size Price
racBenidipine B157508 0.5mg $45
CONIEL 95.00% API0002106 100MG $693
Benidipine 18512 25mg $1500
CONIEL 95.00% API0002106 1G $1501.5
Benidipine 3003B 100mg $89
More product size
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Benidipine Properties

Boiling point 625.2±55.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
pka pKa 7.34(H2O(long extrapolation) ) (Uncertain)
Water Solubility 316μg/L at 25℃
InChIKey QZVNQOLPLYWLHQ-GRHWAJSLNA-N
SMILES [C@H]1(C(C(=O)OC)=C(NC(C)=C1C(=O)O[C@@H]1CCCN(CC2=CC=CC=C2)C1)C)C1=CC=CC([N+]([O-])=O)=C1 |&1:0,14,r|
LogP 4.61
CAS DataBase Reference 105979-17-7(CAS DataBase Reference)
FDA UNII 4G9T91JS7E
ATC code C08CA15

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501

Benidipine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B157508 racBenidipine 105979-17-7 0.5mg $45 2021-12-16 Buy
American Custom Chemicals Corporation API0002106 CONIEL 95.00% 105979-17-7 100MG $693 2021-12-16 Buy
Medical Isotopes, Inc. 18512 Benidipine 105979-17-7 25mg $1500 2021-12-16 Buy
American Custom Chemicals Corporation API0002106 CONIEL 95.00% 105979-17-7 1G $1501.5 2021-12-16 Buy
AvaChem 3003B Benidipine 105979-17-7 100mg $89 2021-12-16 Buy
Product number Packaging Price Buy
B157508 0.5mg $45 Buy
API0002106 100MG $693 Buy
18512 25mg $1500 Buy
API0002106 1G $1501.5 Buy
3003B 100mg $89 Buy

Benidipine Chemical Properties,Uses,Production

Uses

Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

in vivo

Benidipine (3, 5, 10 μg/kg; i.v.) shows significant anti-apoptosis effects in a haemodynamically independent manner[2].
Benidipine (5 mg/kg; i.v.; every other day for 6 weeks) increases the activity of endothelial cell-type nitric oxide synthase (eNOS) and improves coronary circulation in hypertensive rats[3].
Benidipine (1, 3, 10 mg/kg; p.o.; once daily for 1 week) significant cardioprotective effects against ischemia-reperfusion injury[4].

Animal Model:Sham MI (myocardial ischaemia)/R (ischmia reperfused injury) rabbits and MI/R rabbits[2]
Dosage:3, 5, 10 μg/kg
Administration:I.v.
Result:Caused a significant decreased in HR ( heart rate), MABP (mean arterial blood pressure), PRI (pressure-rateindex) at 10 μg/kg, decreased apoptotic positive cells to7.4% at 3 μg/kg and not significantly different from that seen in the group treated with higher dose.
Animal Model:Renovascular hypertensive rats (RHR)[3]
Dosage:5 mg/kg (dissolved in peanut oil)
Administration:I.v.; every other day for 6 weeks
Result:Significantly decreased the blood pressure and coronary vascular resistance index, but increased nitrite production and eNOS mRNA expression and significantly increased the coronary flow at rest, the capillary density.
Animal Model:Rats (heart model (Langendorff perfusion))[4]
Dosage:1, 3, 10 mg/kg
Administration:P.o.; once daily for 1 week
Result:Significantly increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%; LV dP/dt max: 97.8±10.4 vs 70.2±15.7%; p<0.05) at 3 mg/kg.

Enzyme inhibitor

This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.

Benidipine Preparation Products And Raw materials

Raw materials

3,5-Pyridinedicarboxylic acid Methyl 3-aminocrotonate Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1-Benzyl-3-piperidinol

Preparation Products

Benidipine Suppliers

Global( 129)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 10000 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15082 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9080 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Shanghai Quedan biology science and technology co., ltd 		+86-13004146052 lnzc@quedan.com.cn China 1022 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49968 58
Supplier Advantage
career henan chemical co 		58
Shandong chuangyingchemical Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Healthchem Co., Ltd. 		58
Baoji Guokang Healthchem co.,ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shanghai Quedan biology science and technology co., ltd 		58
GIHI CHEMICALS CO.,LIMITED 		58

View Lastest Price from Benidipine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Benidipine pictures 2026-04-20 Benidipine
105979-17-7
 US $2785.00-3520.00 / mg 10g TargetMol Chemicals Inc.
Benidipine pictures 2021-07-13 Benidipine
105979-17-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Benidipine pictures 2021-07-10 Benidipine
105979-17-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Benidipine pictures
  • Benidipine
    105979-17-7
  • US $2785.00-3520.00 / mg
  • TargetMol Chemicals Inc.
  • Benidipine pictures
  • Benidipine
    105979-17-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Benidipine pictures
  • Benidipine
    105979-17-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

105979-17-7(Benidipine)Related Search:

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Benzyltrimethylammonium chloride Benzyl nicotinate ETHANE Benzyl benzoate Chlorodimethylphenylsilane
Benzyltriethylammonium chloride Dimethyl sulfoxide N,N-Dimethylformamide Diphenoxylate 2-(Diethylamino)ethyl methacrylate
Benidipine hydrochloride 1-Benzyl-3-piperidinol hydrochloride Nitrendipine

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(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel- NACADIPINE BENIDIPINE BENIDIPINE HCL CAPADIPINE CONIEL KW-3049 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-(+-)- (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester rac Benidipine Benidipine USP/EP/BP RAC Benidipine D7 Benidipene 105979-17-7 C28H31N3O6HCl Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Pharmaceutical